The clinical evaluation of Vi-one chlorhexidine mouthwash on plaque-induced gingivitis: A double-blind randomized clinical trial

Abstract

BackgroundChlorhexidine (CHX) is the most effective antiseptic mouthwash to date. Essential oil such as thymol, have inhibitory and biocidal effects a range of bacteria.ObjectiveTo determine the effect of mouthwash containing CHX and thymol on plaque induced gingivitis.MethodsThis double-blind randomized clinical trial study was performed on 60 patients with plaque induced gingivitis who were randomly divided into two groups: Group I (CHX/thymol mouthwash-Vi-one) and Group II (CHX mouthwash-Behsa). Patients in each group underwent scaling and root planning and polishing, then were educated about BASS-Method brushing, and were recommended Oral-B toothbrushes and Pooneh toothpaste. The two groups were asked to rinse their mouths for 60 seconds twice a day, once in the morning and once at night, after brushing their teeth. Plaque index, gingival index, bleeding index and stain index were evaluated at baseline and 14 days later in Ramfjord teeth. Data analysis was conducted using SPSS version 21. Independent-samples t-test and paired-samples t-test were used for data analysis.ResultsThe results showed that plaque index and gingival index significantly reduced in two groups (p<0.001). However, group I was significantly more efficient than group II (p<0.001, p=0.021 respectively). Similar results were observed in terms of bleeding index with the difference that the two groups did not differ significantly from each other (p=0.879). Both groups significantly increased the stain index. No remarkable difference was also observed between the two groups (p=0.754).ConclusionBased on the results of this study, we can conclude that the CHX/thymol mouthwash can be offered to patients with dental plaque-induced gingivitis, because it appears to be more effective in controlling dental plaque and gingivitis.Trial registrationThe trial was registered at the Iranian Registry of Clinical Trials (http://www.irct.ir) with the Irct ID: IRCT201602231760N45.FundingThis study was part of a thesis and research project (Grant No: 9440921) supported and funded by Babol University of Medical Sciences. The authors received no financial support from Behsa pharmaceutical company (Behsa mouthwash manufacturer) or Rojin cosmetic laboratory (Vi-one mouthwash manufacturer) for this study.

Clinical Impact and Cosmetic Acceptability of Chlorhexidineenriched Toothpaste and Mouthwash Application on Periodontal Disease: A Randomized Clinical Study

“…Nevertheless, all indices to evaluate periodontal disease show advantages and disadvantages 31 and the PDI 23 remains a useful method widely used in clinical studies. 29,[32][33][34] In summary, our results support the incorporation of both pharmaceutical presentations of these product formulations into daily routine dental care as an effective method to manage PD.…”

“…However, our studies show promising effects of both TP and MW after 21 days of usage, a time which is in line with what it has been reported in some recent studies evaluating chlorhexidine-containing products. 29,30 On the other hand, another possible limitation could be related to the methodology used to assess periodontal disease. Thus, some complementary scores and/or manual probes could have been applied.…”

The Assessment of Nigella Sativa oil as a Therapeutic Aid for Gingivitis: A Randomized Clinical Trial

“…On the other hand, N. Sativa may be a safer natural candidate for maintaining oral health, fostered by its antimicrobial and anti-in ammatory effects [14]. Previous studies have compared the effect of CHX and essential oils on plaque index and gingival index [19,25]. In some cases, clinical trials assessing CHX were conducted for 2 weeks or less [19,26], and others for longer [27,28].…”

“…Previous studies have compared the effect of CHX and essential oils on plaque index and gingival index [19,25]. In some cases, clinical trials assessing CHX were conducted for 2 weeks or less [19,26], and others for longer [27,28]. We chose a 14-day study term based on the standard prescribed duration of use for CHX.…”

“…The sample size was calculated to be 23 having 80% power to detect a difference in means of 0.16, assuming a standard deviation of difference of 0.22, using a paired t-test with a 5% two-sided signi cance level. The mean values were based on the mean plaque index and standard deviations described by Amoian et al 2017 [19]. Previous studies conducted to assess the effectiveness of herbal products on periodontal disease also used a sample size of 15-20 participants, where a statistically signi cant difference in the parameters after the intervention was reported [20,21].…”