The clinical appearance of clonal nevi (inverted type A nevi)

Huynh, Phung M.; Glusac, Earl J.; Bolognia, Jean L.

doi:10.1111/j.1365-4632.2004.02133.x

Cited by 21 publications

(14 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevi may display eccentric dark dots which can represent epidermal or dermal pigmentation90 or a clonal nevus 91. In their prospective analysis of 59 nevi with foci of hyperpigmentation, Bolognia et al90 found that most were benign but 3 lesions (5%) revealed melanoma.…”

Section: Visual Detectionmentioning

confidence: 99%

Strategies for early melanoma detection: Approaches to the patient with nevi

Goodson¹,

Grossman²

2009

Journal of the American Academy of Dermatology

160

View full text Add to dashboard Cite

Given its propensity to metastasize, and lack of effective therapies for most patients with advanced disease, early detection of melanoma is a clinical imperative. Although there are no non-invasive techniques for definitive diagnosis of melanoma, and the "gold standard" remains biopsy with histologic examination, a variety of modalities may facilitate early melanoma diagnosis and the detection of new and changing nevi. This article reviews general clinical principles of early melanoma detection, and various modalities that are currently available or on the horizon, providing the clinician with an up-to-date understanding of management strategies for their patients with numerous or atypical nevi.Learning objectives-At the conclusion of this learning activity, participants should: 1) understand the clinical importance of early melanoma detection; 2) appreciate the challenges of early melanoma diagnosis and which patients are at highest risk; 3) know general principles of early melanoma detection; 4) be familiar with current and emerging modalities that may facilitate early melanoma diagnosis and the detection of new and changing nevi; 5) know the advantages and limitations of each modality; and 6) be able to practice a combined approach to the patient with numerous or clinically atypical nevi.

show abstract

Section: Visual Detectionmentioning

confidence: 99%

Strategies for early melanoma detection: Approaches to the patient with nevi

Goodson¹,

Grossman²

2009

Journal of the American Academy of Dermatology

160

View full text Add to dashboard Cite

show abstract

“…Such results are in keeping with those of other studies. [1][2][3][4]6,7 Patients with NFAEC were only slightly younger than those with DPN (average age 25.4 years vs 28.3 years). Clearly, a limitation of our study is that we were unable to establish the temporal evolution of the lesion prior to biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…3,6,7 This entity has also been referred to as a ''clonal nevus,'' akin to ''clonal seborrheic keratoses.'' In fact, the original series of NFAEC was submitted as ''clonal nevi,'' but the term NFAEC was suggested during peer review.…”

mentioning

confidence: 98%

See 1 more Smart Citation

Is melanocytic nevus with focal atypical epithelioid components (clonal nevus) a superficial variant of deep penetrating nevus?

High

Alanen

Golitz

2006

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

“…Recognizing the atypical maturation, Dr. Richard Reed coined the term inverted type‐A nevus (personal communications), which has been described in a textbook . The term first appeared in the PubMed literature in 2004, reporting a series of 5 lesions, focusing on the clinical appearance. To better define this entity and the significance of atypia, we characterized the clinicopathological features of 121 patients with a single melanocytic lesion, whose biopsies showed a biphasic nevus with epithelioid/spindled nesting deep in the dermis.…”

Section: Introductionmentioning

confidence: 99%

Histological features and outcome of inverted type‐A melanocytic nevi

Dadras

Zembowicz

et al. 2018

J Cutan Pathol

View full text Add to dashboard Cite

The presence of enlarged epithelioid/spindled nests located deep in the reticular dermis of a biphasic melanocytic neoplasm can mimic melanoma arising in a pre-existing nevus, causing over-interpretation of malignancy. We aimed to define the clinicopathologic significance of epithelioid/spindled nests in melanocytic nevi. Retrospectively using clinical and histologic information, we characterized 121 patients with a single lesion showing epithelioid/spindled melanocytes in the reticular dermis or subcutaneous fat, surrounded by melanophages, sometimes blending in with the adnexa. The majority of nevi occurred in women in the ages of 10 to 39 years, where the most frequent presentation was a changing mole. While 78% of the lesions displayed an anatomic (Clark's) level of IV-V, there was no ulceration, significant regression or inflammation. Up to 2 mitoses were found in only 12% of the cases, not correlating with the severity of cytological atypia. No recurrence or metastasis occurred during 45.5 months (mean) of clinical follow up in 26 patients. Notwithstanding the deep dermal extension, these findings suggest a benign histopathology and clinical outcome. Having compared the overlapping histopathology and clinical features between deep penetrating/clonal nevus and combined nevus, we posit that "inverted type-A nevus" might be considered a variant of the two.

show abstract

The clinical appearance of clonal nevi (inverted type A nevi)

Abstract: The appearance of clonal nevi--tan with a focus of blue-gray to blue-black pigmentation--allows one to recognize the lesion clinically.

Cited by 21 publications

References 5 publications

Strategies for early melanoma detection: Approaches to the patient with nevi

Strategies for early melanoma detection: Approaches to the patient with nevi

Is melanocytic nevus with focal atypical epithelioid components (clonal nevus) a superficial variant of deep penetrating nevus?

Histological features and outcome of inverted type‐A melanocytic nevi

Contact Info

Product

Resources

About