Strategies for early melanoma detection: Approaches to the patient with nevi

Goodson, Agnessa Gadeliya; Grossman, Douglas

doi:10.1016/j.jaad.2008.10.065

Cited by 157 publications

(52 citation statements)

References 169 publications

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“…Finally, sequential follow-up of melanocytic lesions, although routine in medical practice, could be readily implemented via temporally separated remote assessments. As is well recognised, detecting meaningful change in melanocytic lesions may, in some cases, be the only way of reliably diagnosing melanoma [8]. …”

Section: Discussionmentioning

confidence: 99%

“…While the prognosis for patients with advanced disease remains poor, melanoma can be cured if treated early [3,4,5,6,7]. Dermatologists and other health professionals have therefore promoted a number of strategies to increase the rates of early detection of melanoma [7,8], including, but not limited to: educational campaigns about sun safety [9] and the importance of skin self-examination (SSE) [10], a user-generated web-based dermoscopy image archive as a contribution to E-learning and exchange of knowledge [11], regular screening examinations by primary health care physicians or dermatologists, and the application of innovative clinical tools such as dermoscopy and total body imaging [8,9,10,11,12,13]. …”

Section: Introductionmentioning

confidence: 99%

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The Remote Assessment of Melanocytic Skin Lesions: A Viable Alternative to Face-to-Face Consultation

Boyce¹,

Gilmore²,

Xu³

et al. 2011

Dermatology

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Background: The incidence of melanoma continues to rise in the Western world, prompting health care professionals to search for novel tools that may increase rates of early detection. Here we focus on one such tool: remote specialist diagnosis of melanocytic lesions utilising mobile-phone camera patient-generated clinical images. Objective: We aim to test the hypothesis that patient-generated clinical images utilising mobile phones are of acceptable quality, and that digital image diagnostic outcomes are comparable with face-to-face (FTF) diagnostic outcomes. Methods: Study participants were asked to photograph, using their mobile-phone camera any number of their own melanocytic naevi, and then upload these clinical images to a central server. Diagnostic accuracy of the management decision based on assessing these digital images was tested by comparing results from digital image assessment with results from FTF assessments. Results: We provide evidence that suggests potential patients are capable of uploading good quality clinical images of melanocytic lesions for diagnostic purposes, and we show that good concordance rates can be achieved with respect to digital image and FTF diagnostic outcomes. With respect to the latter, exact agreement was found in 116 of 167 assessable lesions (69%). Conclusions: This work suggests that specialist remote diagnosis of patient-generated clinical images of melanocytic lesions utilising mobile-phone cameras may be a viable alternative to traditional FTF assessments.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Remote Assessment of Melanocytic Skin Lesions: A Viable Alternative to Face-to-Face Consultation

Boyce¹,

Gilmore²,

Xu³

et al. 2011

Dermatology

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“…However, melanoma is an aggressive malignancy that tends to metastasize beyond its primary site (7,12). Once melanoma is advanced, surgery is no longer sufficient and the disease becomes more difficult to treat (7,(12)(13)(14). Long-term prognosis after metastasis is grim; median survival with treatment, including treatment with immunotherapeutics like Ipilimumab, ranges from 8 to 12 months (6,13,14).…”

Section: Introductionmentioning

confidence: 99%

“…Once melanoma is advanced, surgery is no longer sufficient and the disease becomes more difficult to treat (7,(12)(13)(14). Long-term prognosis after metastasis is grim; median survival with treatment, including treatment with immunotherapeutics like Ipilimumab, ranges from 8 to 12 months (6,13,14). However, more recently developed combined immunotherapeutic treatments with radiation can improve survival further to several years (13).…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Melanoma

Matthews

Qureshi

et al. 2017

Cutaneous Melanoma: Etiology and Therapy

266

321

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Melanoma is a potentially lethal cancer that is most commonly cutaneous. The worldwide incidence of melanoma has risen rapidly over the course of the last 50 years. Its incidence is greatest among fair-skinned populations, and in regions of lower latitude. Incidence is greater among geriatric populations, but melanoma is also among the most common cancers found in adolescent and young adult populations. In fact, it is one of the leading cancers in average years of life lost per death from disease. Melanoma incidence varies by sex, which is also associated with differences in melanoma anatomic site. Similar differences by region, ethnicity, age, and sex are observed in mortality rates of melanoma. In the setting of rising incidence and mortality, melanoma bears a heavy health and economic burden. Attributable costs are several billion in nations with greater melanoma incidence. Preventative strategies have been implemented in multiple high-risk regions with variable success. It is imperative that research efforts Epidemiology of Melanoma 4 achieve better understanding of the risk factors and etiology of disease, with the goal to halt and reverse the progressive trend of rising incidence and mortality from melanoma.

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“…Besides HFUS, confocal microscopy and OCT have emerged in recent years as imaging modalities providing real-time evaluation of cutaneous tissue [10,12,13]. Reaching a penetration depth of about 1 mm, layers such as the epidermis and the dermis, adnexal structures, and blood vessels can be well distinguished by OCT [14].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Tumor Thickness in Melanocytic Skin Lesions: Comparison of Optical Coherence Tomography, 20-MHz Ultrasound and Histopathology

Hinz¹,

Ehler²,

Voth³

et al. 2011

Dermatology

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Background: Accurate assessment of vertical tumor size is important for surgical treatment planning of melanocytic skin lesions. High-frequency ultrasound (HFUS) is frequently used for this purpose, but overestimation of tumor thickness is known as a problem especially in thin melanocytic lesions. Optical coherence tomography (OCT) as a new imaging technique might be a promising alternative. Objective: To evaluate the ability of OCT to accurately determine the vertical tumor thickness of melanocytic skin lesions and to compare it with HFUS and histopathology in order to improve surgical planning. Methods: In this single-center study, 26 melanocytic lesions were imaged by OCT and HFUS. Vertical lesion dimensions of both methods were compared with histopathological measurements. Results: Bland-Altman plots for OCT and histopathology as well as for HFUS and histopathology revealed better agreement for OCT and histopathology concerning tumor thickness measurements. Tumor thickness values for the melanocytic lesions measured by OCT presented a median tumor thickness of 0.31 mm (range 0.10–0.77) compared to a median tumor thickness of 0.25 mm (range 0.06–1.5) measured by histopathology. The median tumor thickness of HFUS was 0.44 mm (range 0.23–1.1). A Spearman correlation procedure including the correlation coefficient (r) showed a stronger relationship between OCT and histopathology (r = 0.734) compared to HFUS and histopathology (r = 0.390). Conclusions: On the basis of this smaller study cohort, OCT seems to be more exact than HFUS as far as thickness determination of thin melanocytic skin lesions is concerned.

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Strategies for early melanoma detection: Approaches to the patient with nevi

Cited by 157 publications

References 169 publications

The Remote Assessment of Melanocytic Skin Lesions: A Viable Alternative to Face-to-Face Consultation

The Remote Assessment of Melanocytic Skin Lesions: A Viable Alternative to Face-to-Face Consultation

Epidemiology of Melanoma

Assessment of Tumor Thickness in Melanocytic Skin Lesions: Comparison of Optical Coherence Tomography, 20-MHz Ultrasound and Histopathology

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