The clearance of manganese chloride in the primate

Newland, M. Christopher; Cox, Christopher; Hamada, Rikuzo; Oberdörster, Günter; Weiss, Bernard

doi:10.1016/0272-0590(87)90054-6

Cited by 94 publications

(33 citation statements)

References 21 publications

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“…Data presented in this report, however, revealed that serum manganese concentrations were not significantly associated with welder's professional years. The lack of such an association is not unexpected because a discrepancy between blood half life (t 1/2 ) and tissue t 1/2 of manganese has been documented in several studies (Newland et al, 1987;Takeda et al, 1995;Zheng et al, 2000). While the blood t 1/2 following i.v.…”

Section: Discussionmentioning

confidence: 95%

“…While the blood t 1/2 following i.v. injection of manganese is about 2 h (Zheng et al, 2000), the brain t 1/2 of Mn from inorganic manganese exposure ranges between 50 and 70 days (Newland et al, 1987;Takeda et al, 1995). The intracellular distribution and tight tissue binding of manganese likely contribute to the difference between blood and tissue t 1/2 .…”

Section: Discussionmentioning

confidence: 99%

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Alteration of Serum Concentrations of Manganese, Iron, Ferritin, and Transferrin Receptor Following Exposure to Welding Fumes Among Career Welders

Zhang

et al. 2005

NeuroToxicology

105

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This study was performed to determine airborne manganese levels during welding practice and to establish the relationship between long-term, low-level exposure to manganese and altered serum concentrations of manganese, iron, and proteins associated with iron metabolism in career welders. Ninety-seven welders (average age of 36 years) who have engaged in electric arc weld in a vehicle manufacturer were recruited as the exposed group. Welders worked 7-8 h per day with employment duration of 1-33 years. Control subjects consisted of 91 employees (average age of 35 years) in the same factory but not in the welding profession. Ambient manganese levels in welders' breathing zone were the highest inside the vehicle (1.5 ± 0.7 mg/m 3 ), and the lowest in the center of the workshop (0.2 ± 0.05 mg/m 3 ). Since the filter size was 0.8 μm, it is possible that these values may be likely an underestimation of the true manganese levels. Serum levels of manganese and iron in welders were about three-fold (p < 0.01) and 1.2-fold (p < 0.01), respectively, higher than those of controls. Serum concentrations of ferritin and transferrin were increased among welders, while serum transferrin receptor levels were significantly decreased in comparison to controls. Linear regression analyses revealed a lack of association between serum levels of manganese and iron. However, serum concentrations of iron and ferritin were positively associated with years of welder experience (p < 0.05). Moreover, serum transferrin receptor levels were inversely associated with serum manganese concentrations (p < 0.05). These findings suggest that exposure to welding fume among welders disturbs serum homeostasis of manganese, iron, and the proteins associated with iron metabolism. Serum manganese may serve as a reasonable biomarker for assessment of recent exposure to airborne manganese.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Alteration of Serum Concentrations of Manganese, Iron, Ferritin, and Transferrin Receptor Following Exposure to Welding Fumes Among Career Welders

Zhang

et al. 2005

NeuroToxicology

105

View full text Add to dashboard Cite

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“…injection of MnCl 2 in rats is only about 2 h; such a short half life, in theory, would not result in the accumulation of Mn in the body (Zheng et al, 2000). However, tissue analyses suggest that the biological half life of Mn in brain tissues is between 51 and 74 days (Newland et al, 1987;Takeda et al, 1995). Thus, it is possible that the intracellular binding and sequestration of Mn ions may prevent the metal from migration to the extracellular space.…”

Section: Introductionmentioning

confidence: 99%

Brain magnetic resonance imaging and manganese concentrations in red blood cells of smelting workers: Search for biomarkers of manganese exposure

Jiang¹,

Zheng²,

Лонг³

et al. 2007

NeuroToxicology

125

128

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The MRI technique has been used in diagnosis of manganism in humans and non-human primates. This cross-sectional study was designed to explore whether the pallidal signal intensity in T1-weighted MRI correlated with Mn levels in the blood compartment among Mn-exposed workers and to understand to what extent the MRI signal could reflect Mn exposure. A group of 18 randomly selected male Mn-exposed workers of which 13 were smelting workers with high exposure (mean of airborne Mn in work place: 1.26 mg/m 3 ; range: 0.31-2.93 mg/m 3 ), and 5 power distribution control workers with low exposure (0.66 mg/m 3 and 0.23-0.77 mg/m 3 ) from a ferroalloy factory, and another group of 9 male subjects as controls from a non-smelting factory who were office or cafeteria workers (0.01 mg/m 3 and 0-0.03 mg/m 3 ) were recruited for neurological tests, MRI examination, and analysis of Mn in whole blood (MnB), plasma (MnP) or red blood cells (MnRBC). No clinical symptoms and signs of manganism were observed among these workers. MRI data showed average increases of 7.4% (p < 0.05) and 16.1% (p < 0.01) in pallidal index (PI) among low-and high-exposed workers, respectively, as compared to controls. Fourteen out of 18 Mn-exposed workers (78%) had intensified PI values, while this proportion was even higher (85%) among the high Mn-exposed workers. Among exposed workers, the PI values were significantly associated with MnRBC (r = 0.55, p = 0.02). Our data suggest that the workers exposed to airborne Mn, but without clinical symptoms, display an exposure-related, intensified MRI signal. The MRI, as well as MnRBC, may be useful in early diagnosis of Mn exposure.

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“…Toxicidade por Mn tem sido descrita em mineiros expostos à inalação 25 e em modelos experimentais animais 32 . Os sintomas iniciais decorrentes da deposição de Mn no SNC são inespecíficos, incluindo astenia, anorexia, irritabilidade, insônia, violência incontrolável e labilidade emocional.…”

Section: B a C D Discussãounclassified

Hiperintensidade de sinal em T1 dos núcleos da base: relato de caso na encefalopatia portal sistêmica esquistossomótica

Júnior¹,

Gaspar-Sobrinho²,

Barbosa³

et al. 1999

Arq. Neuro-Psiquiatr.

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RESUMO -Relatamos o caso de uma paciente portadora de esquistossomose mansônica com encefalopatia portal sistêmica, associada a elevada intensidade de sinal em T1 ao nível dos núcleos da base, devido a deposição de manganês, decorrente da presença de colaterais porto-sistêmicos. Ressaltamos os achados radiológicos por ressonância magnética e fazemos revisão bibliográfica sobre o tema. Desconhecemos relato de tal associação na bibliografia.PALAVRAS-CHAVE: esquistossomose mansônica, encefalopatia portal sistêmica, gânglios da base, manganês, neurorradiologia, ressonância magnética. Hyperintense basal ganglia on T1 weighted MR images: case report in Manson's Schistosomiasis with portal-systemic encephalopathyABSTRACT -We report a case of mansonic schistosomiasis with portal systemic encephalopathy associated with a high intensity signal in basal ganglia on T1 weighted images due to deposition of manganese in tissues related with portal-systemic collateral vessels. A bibliographic review was done focusing the magnetic resonance findings. To the best of our knowledge, these signal changes have not yet been associated with Manson's schistosomiasis.KEY WORDS: mansonic schistosomiasis, portal-systemic encephalopathy, basal ganglia, manganese, neuroradiology, magnetic resonance image.Em 1954, Sherlock utilizou a expressão encefalopatia portal sistêmica (EPS) para denominar uma síndrome neurológica que se manifesta ocasionalmente em pacientes com hepatopatia crônica com shunts porto-sistêmicos 1 . As alterações observadas no exame de ressonância magnética (RM) são caracterizadas por hiperintensidade de sinal em T1 nos núcleos da base, características da EPS 2 . Este achado foi inicialmente descrito por alguns autores em casos associados à insuficiência hepática crônica 3-6 , posteriormente em casos de shunt portal sistêmico sem insuficiência hepática 7 , e, mais recentemente, em pacientes submetidos a nutrição parenteral 8,9 . A sua etiopatogenia está associada com a deposição intracelular de manganês (Mn).A esquistossomose mansoni é endêmica em regiões da América, África e Oriente Próximo. Está presente em cerca de 53 países. O agente etiológico é o Schistosoma mansoni, um trematoda que tem o homem como hospedeiro definitivo e único reservatório de importância epidemiológica. A doença se caracteriza por expressão clínica variável, desde formas assintomáticas / oligossintomáticas a quadros graves com hipertensão portal e raramente hipertensão pulmonar. A Estudo realizado no Setor

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The clearance of manganese chloride in the primate

Cited by 94 publications

References 21 publications

Alteration of Serum Concentrations of Manganese, Iron, Ferritin, and Transferrin Receptor Following Exposure to Welding Fumes Among Career Welders

Alteration of Serum Concentrations of Manganese, Iron, Ferritin, and Transferrin Receptor Following Exposure to Welding Fumes Among Career Welders

Brain magnetic resonance imaging and manganese concentrations in red blood cells of smelting workers: Search for biomarkers of manganese exposure

Hiperintensidade de sinal em T1 dos núcleos da base: relato de caso na encefalopatia portal sistêmica esquistossomótica

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