The CKD-EPI and MDRD equations to estimate GFR. Validation in the Swedish Lund-Malmö Study cohort

Nyman, Ulf; Grubb, Anders; Sterner, Gunnar; Björk, Jonas

doi:10.3109/00365513.2010.543143

Cited by 49 publications

(41 citation statements)

References 19 publications

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“…However, none of these two equations is optimal for all GFR ranges, patient subgroups, different nationalities and ethnicities [5][6][7][8][9][10][11][12][13]. Validation results may also be influenced by the chosen reference GFR measurement method [14,15] and by the calibration of the creatinine assay as well as type of creatinine assay method [16].…”

Section: Introductionmentioning

confidence: 99%

“…One possible explanation for this could be that LM Revised has two age terms with opposite signs (see Appendix), which opens up for a more accurate handling of expected changes in Brought to you by | Lund University Libraries Authenticated Download Date | 4/27/15 3:15 PM GFR, but also in muscle mass, across the life span. There is evidence suggesting that both MDRD and CKD-EPI may overestimate GFR not only among elderly but also among young adults [10,12]. Furthermore, the difference in the structure of the equations means that LM Revised, as opposed to MDRD and CKD-EPI, can also be applied among children [17].…”

Section: Introductionmentioning

confidence: 99%

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The revised Lund-Malmö GFR estimating equation outperforms MDRD and CKD-EPI across GFR, age and BMI intervals in a large Swedish population

Nyman

Grubb

Larsson

et al. 2014

Clinical Chemistry and Laboratory Medicine (CCLM)

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The revised Lund-Malmo GFR estimating equation outperforms MDRD and CKD-EPI across GFR, age and BMI intervals in a large Swedish populationNyman, Ulf; Grubb, Anders; Larsson, Anders; Hansson, Lars-Olof; Flodin, Mats; Nordin, Gunnar; Lindstrom, Veronica; Björk, Jonas General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Results:The overall results of LM Revised/MDRD/ CKD-EPI were: median bias 2%/8%/11%, IQR 12/14/14 mL/min/1.73 m 2 , P 10 40%/35%/35% and P 30 84%/75%/76%. LM Revised was the most stable equation in terms of bias, precision and accuracy across mGFR, age and BMI intervals irrespective of gender. MDRD and CKD-EPI overestimated mGFR in patients with decreased kidney function, young adults and elderly. All three equations overestimated mGFR and had low accuracy in patients with BMI < 20 kg/m 2 , most pronounced among men. Conclusions: In settings similar to the investigated cohort LM Revised should be preferred to MDRD and CKD-EPI due to its higher accuracy and more stable performance across GFR, age and BMI intervals.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The revised Lund-Malmö GFR estimating equation outperforms MDRD and CKD-EPI across GFR, age and BMI intervals in a large Swedish population

Nyman

Grubb

Larsson

et al. 2014

Clinical Chemistry and Laboratory Medicine (CCLM)

Self Cite

157

149

View full text Add to dashboard Cite

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“…The literature on validation of the CKD-EPI formula in children remains scarce. One study of 850 children and adults aged 5 -95 years comes to the conclusion that the formula should not be used for children and youth (92) .…”

Section: Estimating Gfr Using Creatininementioning

confidence: 99%

The usefulness of cystatin C and related formulae in pediatrics

Filler

Huang

Yasin

2012

Clinical Chemistry and Laboratory Medicine (CCLM)

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Serum creatinine does not share the properties of an ideal marker of glomerular fi ltration rate (GFR) like inulin, but continues to be the most widely used endogenous marker of GFR. In the search of a better biomarker of GFR, the small molecular weight protein cystatin C has been introduced with features more similar to that of inulin, such as constant production and no non-renal elimination. However, it has not enjoyed widespread use despite its signifi cantly improved diagnostic performance in the detection of impaired GFR and its independence of body composition. A variety of formulae based on either cystatin C or creatinine or both have been developed to estimate GFR. We summarize the currently used methods of GFR measurement, their limitations and analytical errors. The review also summarizes the history, features and the feasibility of cystatin C measurements as well as the most widely used formulae for the estimation of GFR in children. The diagnostic performance of the cystatin C derived eGFR formulae at various levels of GFR is also discussed. An eGFR formula derived from pooled studies analyzing both creatinine and cystatin C, and using a biology-based mathematical approach may be advantageous.

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“…Metastaz ve nüks açısından değerlendirme için toraks-abdomen-pelvis bilgisayarlı tomografisi kullanıldı. GFO, böbrek hastalığında diyet modifikasyonu (MDRD) formülü ile hesaplandı (8). Takipte 6 ayda bir bakılan GFO ölçümleri kaydedildi.…”

Section: Takip Aralıkları Ve Renal Fonksiyonların Değerlendirilmesiunclassified

“…Ayrıca bu çalışmada hipertansiyon öyküsü olan, postoperatif dönemde hidronefroz ve piyelonefrit gelişen hastaların GFO'larının daha fazla düştüğü de bildirilmiştir. Renal fonksiyon bozukluğu tanımı olarak MDRD formülüne göre yıllık 1 mL/dk/1,73 m 2 GFO düşüşünün anlamlı olarak kabul edildiği diğer çalışmada ise takip süresi sonunda hastaların sadece %3'ünde GFO düşüşünün olduğu, anastomoz darlığı olan hastaların daha düşük GFO'ya sahip oldukları raporlanmıştır (8). Aynı çalışmada 10 yıl hayatta kalan hastaların %17'sinde GFO'nun 60'ın altına düşerek böbrek yetmezliği geliştiği de bildirilmiştir.…”

Section: Bulgularunclassified

Renal Function Deterioration After Radical Cystectomy and Analysis of Predictive Factors for Renal Deterioration

Hamidi¹,

Süer²,

Özkıdık³

et al. 2017

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Objective: Renal function deterioration develops in most of the patients treated with radical cystectomy (RC). In this study, we aimed to evaluate the changes in renal function of bladder cancer (BC) patients who had minimum 5 years of follow-up period after RC. Materials and Methods: In this study, 175 patients who underwent RC for BC at our institution between January 1995 and December 2010 were included. Age, gender, baseline glomerular filtration rate (GFR) before RC, tumor histology, pathological tumor stage, comorbidity record and presence of hydronephrosis before treatment were evaluated. GFR was calculated with the modification of diet in renal disease equation. GFR measurements of every 6 months were recorded in the follow-up. Results: The mean age and mean GFR before RC were 66.5±17.9 years and 91.1±18.2 mL/min, respectively. Patients separated into two groups for having ileal conduit diversion and ileal substitution (IS). It was found out that although baseline GFRs were similar for both groups, GFR was significantly lower in patients of RC with IS after the first year of follow-up period. According to multivariate logistic analysis, having IS as a diversion method (p=0.0001, odds ratio (OR): 3.2, 95% confidence interval (CI): 1.248-5.481), presence of diabetes mellitus record (p=0.0001, OR: 4.9, 95% CI: 2.575-9.706) and presence of hypertension record (p=0.0001, OR: 3.6, 95% CI: 2.019-6.552) were found to be associated with decrease in GFR. Conclusion: Renal function deterioration mostly develops in patients after RC surgery within 5 years. Renal function deterioration was more prominent in IS patients who had diabetes mellitus, hypertension record. Keywords: Bladder cancer, radical cystectomy, renal deterioration Amaç: Radikal sistektomi (RS) yapılan hastaların çoğunda böbrek fonksiyonlarında bozulma gelişmektedir. Bu çalışmada RS yapılan ve en az 5 yıllık takibi olan mesane kanseri (MK) hastalarında renal fonksiyonlardaki değişiklikleri değerlendirmeyi amaçladık. Gereç ve Yöntem: Ocak 1995-Aralık 2010 arasında kliniğimizde MK nedeniyle RS yapılan 175 hasta çalışmaya dahil edildi. Yaş, cinsiyet, RS öncesi bazal glomerüler filtrasyon oranı (GFO), tümör histolojisi, patolojik tümör evresi, komorbidite öyküsü ve tedavi öncesi hidronefroz varlığı değerlendirildi. GFO; böbrek hastalığında diyet modifikasyonu formülü ile hesaplandı. Takipte 6 ayda bir bakılan GFO ölçümleri kaydedildi. Bulgular: Ortalama yaş ve ortalama RS öncesi GFO sırasıyla 66,5±17,9 yıl ve 91,1±18,2 mL/dk idi. Hastalar ileal kondüit diversiyon ve ileal substitüsyon (İS) yapılmasına göre iki gruba ayrıldı. Her iki grubun bazal GFO değerleri benzer olduğu halde ilk yıldan sonraki takip dönemlerinde RS ile birlikte İS yapılan hastalarda GFO'ların istatistiksel olarak daha düşük olduğu izlendi. Çok değişkenli analizde, diversiyon yöntemi olarak İS yapılması (p=0,0001, göreceli olasılıklar oranı (OR): 3,2, %95 güven aralığı (GA): 1,248-5,481), diabetes mellitus öyküsü varlığı (p=0,0001, OR: 4,9, %95 GA: 2,575-9,706) ve hipertansiyon öyküsün...

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The CKD-EPI and MDRD equations to estimate GFR. Validation in the Swedish Lund-Malmö Study cohort

Cited by 49 publications

References 19 publications

The revised Lund-Malmö GFR estimating equation outperforms MDRD and CKD-EPI across GFR, age and BMI intervals in a large Swedish population

The revised Lund-Malmö GFR estimating equation outperforms MDRD and CKD-EPI across GFR, age and BMI intervals in a large Swedish population

The usefulness of cystatin C and related formulae in pediatrics

Renal Function Deterioration After Radical Cystectomy and Analysis of Predictive Factors for Renal Deterioration

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