The Circadian Variations in Systemic Blood Pressure, Ocular Perfusion Pressure, and Ocular Blood Flow: Risk Factors for Glaucoma?

Werne, Adam; Harris, Alon; Moore, Danny; Ben-Zion, Itay; Siesky, Brent

doi:10.1016/j.survophthal.2008.08.021

Cited by 68 publications

(43 citation statements)

References 78 publications

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“…Vascular theory [6][7][8]4] changed the treatment strategy. Decreased of ocular perfusion pressure and increased of vascular resistance of the choroidal vessels [9] is the vascular factor for structural and functional changes [7,8]. We detected statistically significant decrease of ocular blood flow (OBF), of pulse amplitude (PA), of ocular perfusion pressure (OPP) with important fluctuation correlated with vascular dysregulation.…”

Section: Discussionmentioning

confidence: 80%

Contemporaneous Concept of Anti Aging Therapy as New Valuable Paradigm on Ocular Blood Flow Enhancement in Glaucoma

Skoufis¹,

Segos²

2017

AOVS

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Section: Discussionmentioning

confidence: 80%

Contemporaneous Concept of Anti Aging Therapy as New Valuable Paradigm on Ocular Blood Flow Enhancement in Glaucoma

Skoufis¹,

Segos²

2017

AOVS

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“…Werne et al, [14], after a review of the literature, confirms that variations in arterial tension, especially big oscillations, negatively affect haematic ocular flow, involving an additional risk in the evolution of glaucoma.…”

Section: Discussionmentioning

confidence: 93%

“…Further, it is known that fluctuation in intraocular pressure constitutes a risk factor for the progression of the damage to the visual field in OAG [3,13,14].…”

Section: Discussionmentioning

confidence: 99%

Large diurnal variation of intraocular pressure in open angle glaucoma in subjects with type a behaviour pattern

Bubella¹,

Bubella²

2014

J Eye Ophthalmol

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Aim:To evaluate the possible causes of the greater perimetric damage found in OAG subjects with type A behaviour and the possible role of psycho-physiological stress. Materials and methods: 80 patients with OAG, 44 women and 36 men, 40 with type A behaviour and 40 with type B studied with the Type A/B Personality Questionnaire (A modified version of the Jenkins Activity Survey), underwent a complete ophthalmologic examination consisting of bio-microscopy, tonometry and daily tonometric curve, examination of the visual field by means of Octopus 1-2-3 computerised perimeter and its assessment with the Glaucoma Staging System 2 (GSS2), morphological monitoring of the Retinal Nerve Fibre Layer (RNFL) with GDxVCC and monitoring of arterial tension (times 8.30 am-10.30 am-12.30 pm-3 pm-5 pm and 7 pm) with a UA-1010 automatic Digital Blood Pressure Monitor device. Results: In subjects with type A behaviour fluctuation in IOP values is observed in the daytime hours in concomitance with similar oscillations in arterial pressure values. In the subjects with type B behaviour both IOP and the arterial pressure values remain more or less constant with oscillations that are not statistically significant. In GSS2 more significant impairment of the visual field is observed in subjects with type A behaviour. In the same subjects, GDxVCC examination shows statistically significant impairment of the values. The NFI index is positively correlated with the perimetric damage (r=0.74). Conclusions: Personality study is an extremely important part of the diagnostic work-up and treatment of OAG. The frequent oscillations in IOP observed in subjects with type A behaviour could constitute a risk factor in the evolution of perimetric damage.

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“…(3) Other Baseline factors associated with increased risk for progression to Glaucoma includes advancing age,(4) gender,(5) body mass index, diurnal variation in IOP. (6) It is also seen that changes in IOP are directly and significantly associated with changes in systemic blood pressure. (7,8) In India more than 60 million women are in the age of 55 yrs because of aging population.…”

Section: Introductionmentioning

confidence: 99%

Intraocular Pressure Changes in Normal and Moderately Hypertensive Post Menopausal Women

C¹,

Sushma²,

Damodar³

et al. 2013

jemds

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BACKGROUND: Elevated Intraocular Pressure (IOP) causes a mechanical stress situation, leading to damage of neurons in retina and their axons resulting in progressive loss of visual field and blindness seen in Glaucoma. Changes in IOP are directly and significantly associated with changes in systemic blood pressures. Blood pressure increases with age in most populations, especially so after menopause. Menopausal women with hypertension are at increased risk of developing elevated IOP. There are limited data about association of moderate changes in blood pressure that often go with treatment for hypertension with IOP. This work was undertaken to study the effect of moderate systemic hypertension on IOP in postmenopausal women. MATERIALS AND METHODS: 40 Normotensive and 40 Hypertensive postmenopausal women participated in the study. All participants satisfied inclusion and exclusion criteria and gave informed consent. Participants underwent detailed clinical and ophthalmologic examination and IOPs were measured using Schiotz Indentation Tonometer. RESULTS: Mean IOP was 15.28+/-2.54 mmHg in normotensive and 19.47+/-3.37 mmHg, in moderately Hypertensive women. IOP was significantly increased (P<0.001**) among the hypertensive post menopausal women compared to normotensives. Subjects with higher SBP had significantly higher IOP (p < 0.001). The mean IOP also showed a significant correlation (p value of 0.001**) to the total number of years after attainment of menopause. CONCLUSIONS: Elevated IOP was seen in postmenopausal women with moderate hypertension associated with treatment. It is therefore essential that postmenopausal hypertensive women are screened regularly for increases in IOP, the only modifiable risk factor for Glaucoma. KEY WORDS: Elevated Intraocular pressure, moderate hypertension, post menopausal women, Glaucoma, Schiotz Indentation Tonometer, systolic blood pressure and diastolic blood pressure (6) It is also seen that changes in IOP are directly and significantly associated with changes in systemic blood pressure. (7,8) In India more than 60 million women are in the age of 55 yrs because of aging population.(9) With women living longer than before, a majority would spend one third of their life in postmenopausal age. Blood pressure increases with age in most populations, especially after menopause there is a sharp increase in the prevalence of hypertension in women. (10) It is evident that postmenopausal women are at increased risk of developing elevated IOP and glaucoma because of presence of multiple risk factors mentioned above. It is seen that of those with glaucomatous visual field loss, less than 50% have received an appropriate diagnosis or treatment according to population surveys. (11,12) Cardiovascular disease is the leading cause of mortality and morbidity in women.(13) and medical intervention has been successful in lowering blood pressure and the subsequent risk of the systemic sequel of high blood pressure. There are limited data about association of IOP to moderate changes ...

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The Circadian Variations in Systemic Blood Pressure, Ocular Perfusion Pressure, and Ocular Blood Flow: Risk Factors for Glaucoma?

Cited by 68 publications

References 78 publications

Contemporaneous Concept of Anti Aging Therapy as New Valuable Paradigm on Ocular Blood Flow Enhancement in Glaucoma

Contemporaneous Concept of Anti Aging Therapy as New Valuable Paradigm on Ocular Blood Flow Enhancement in Glaucoma

Large diurnal variation of intraocular pressure in open angle glaucoma in subjects with type a behaviour pattern

Intraocular Pressure Changes in Normal and Moderately Hypertensive Post Menopausal Women

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