The circadian clock gene <i>Bmal1</i>: Role in COVID-19 and periodontitis

Şehirli, Ahmet Özer; Chukwunyere, Ugochukwu; Aksoy, Umut; Sayıner, Serkan; Abacıoğlu, Nurettin

doi:10.1080/07420528.2021.1895198

Cited by 23 publications

(22 citation statements)

References 55 publications

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“…This number appeared to be higher in another cohort of patients, reaching 31% at 3–4 months postadmission ( 5 ). In addition, a recent meta-analysis including 31 studies demonstrated a pooled prevalence of sleeping disturbances in 34% of 5,153 COVID-19 patients ( 31 ). Nevertheless, all of these findings are based on self-reported assessments.…”

Section: Discussionmentioning

confidence: 99%

Sleep and Circadian Health of Critical COVID-19 Survivors 3 Months After Hospital Discharge

Moncusí‐Moix

Vaca

Gort‐Paniello

et al. 2022

Critical Care Medicine

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OBJECTIVES: To evaluate the sleep and circadian rest-activity pattern of critical COVID-19 survivors 3 months after hospital discharge. DESIGN: Observational, prospective study. SETTING: Single-center study. PATIENTS: One hundred seventy-two consecutive COVID-19 survivors admitted to the ICU with acute respiratory distress syndrome. INTERVENTIONS: Seven days of actigraphy for sleep and circadian rest-activity pattern assessment; validated questionnaires; respiratory tests at the 3-month follow-up. MEASUREMENTS AND MAIN RESULTS: The cohort included 172 patients, mostly males (67.4%) with a median (25th–75th percentile) age of 61.0 years (52.8–67.0 yr). The median number of days at the ICU was 11.0 (6.00–24.0), and 51.7% of the patients received invasive mechanical ventilation (IMV). According to the Pittsburgh Sleep Quality Index (PSQI), 60.5% presented poor sleep quality 3 months after hospital discharge, which was further confirmed by actigraphy. Female sex was associated with an increased score in the PSQI ( p < 0.05) and IMV during ICU stay was able to predict a higher fragmentation of the rest-activity rhythm at the 3-month follow-up ( p < 0.001). Furthermore, compromised mental health measured by the Hospital Anxiety and Depression Scale was associated with poor sleep quality ( p < 0.001). CONCLUSIONS: Our findings highlight the importance of considering sleep and circadian health after hospital discharge. Within this context, IMV during the ICU stay could aid in predicting an increased fragmentation of the rest-activity rhythm at the 3-month follow-up. Furthermore, compromised mental health could be a marker for sleep disruption at the post-COVID period.

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Section: Discussionmentioning

confidence: 99%

Sleep and Circadian Health of Critical COVID-19 Survivors 3 Months After Hospital Discharge

Moncusí‐Moix

Vaca

Gort‐Paniello

et al. 2022

Critical Care Medicine

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“…The SARS-CoV-2 virus disrupts the function of circadian clock genes known as brain and muscle ARNT-like protein 1 (BMAL1) [ 32 ]. The decrease in the level of the BMAL1 gene, which is a regulator of the circadian rhythm, triggers the events leading to the cytokine storm by NFĸB and causes the activation of pro-inflammatory cytokines [ 33 ]. Zhuang et al demonstrated the relationship and role of circadian rhythms in altering the susceptibility of lung epithelial cells to SARS-CoV-2 infection [ 34 ].…”

Section: Melatonin and Importance Of Circadian Rhythm In Covid-19mentioning

confidence: 99%

“…BMAL1 deficiency also triggers increased production of pro-inflammatory cytokines such as TNFα [ 36 ]. Since elevated cytokine levels are important biomarkers that indicate the severity of coronavirus infection, it is important to develop a treatment strategy that takes into account BMAL1 and NFĸB signaling in the management of COVID-19 disease [ 33 , 36 ]. For the management of the NFĸB signaling pathway, melatonin acts as a key molecule to antagonize the reduction in the levels of the Bmal1 gene, which induces a series of events leading to the cytokine storm [ 33 ].…”

Section: Melatonin and Importance Of Circadian Rhythm In Covid-19mentioning

confidence: 99%

“…Since elevated cytokine levels are important biomarkers that indicate the severity of coronavirus infection, it is important to develop a treatment strategy that takes into account BMAL1 and NFĸB signaling in the management of COVID-19 disease [ 33 , 36 ]. For the management of the NFĸB signaling pathway, melatonin acts as a key molecule to antagonize the reduction in the levels of the Bmal1 gene, which induces a series of events leading to the cytokine storm [ 33 ]. The protective and anti-inflammatory effects of melatonin make it a notable therapeutic option to enhance host defense response against viral invasive conditions in COVID-19.…”

Section: Melatonin and Importance Of Circadian Rhythm In Covid-19mentioning

confidence: 99%

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Melatonin and REGN-CoV2 combination as a vaccine adjuvant for Omicron variant of SARS-CoV-2

et al. 2022

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The omicron variant (B.529) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in late 2021, caused panic worldwide due to its contagiousness and multiple mutations in the spike protein compared to the Delta variant (B.617.2). There is currently no specific antiviral available to treat Coronavirus disease 2019 (COVID-19). However, studies on neutralizing monoclonal antibodies (mAb) developed to fight COVID-19 are growing and gaining traction. REGN-COV2 (Regeneron or imdevimab-casirivimab combination), which has been shown in recent studies to be less affected by Omicron's RBD (receptor binding domain) mutations among other mAb cocktails, plays an important role in adjuvant therapy against COVID-19. On the other hand, it is known that melatonin, which has antioxidant and immunomodulatory effects, can prevent a possible cytokine storm, and other severe symptoms that may develop in the event of viral invasion. Along with all these findings, we believe it is crucial to evaluate the use of melatonin with REGN-COV2, a cocktail of mAbs, as an adjuvant in the treatment and prevention of COVID-19, particularly in immunocompromised and elderly patients.

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“…[1][2] The relationship between periodontitis -which has an important role in dental infections -and systemic diseases has been determined. Although the studies in this area have increased, 3,4 the relationship between apical periodontitis and systemic disease has not yet been completely established.…”

mentioning

confidence: 99%

Can Apical Periodontitis Exacerbate Covid-19 Damage?

AKSOY,

Şehirli,

SAYINER

2021

J. Contemp. Med. Sci.

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The circadian clock gene Bmal1: Role in COVID-19 and periodontitis

Cited by 23 publications

References 55 publications

Sleep and Circadian Health of Critical COVID-19 Survivors 3 Months After Hospital Discharge

Sleep and Circadian Health of Critical COVID-19 Survivors 3 Months After Hospital Discharge

Melatonin and REGN-CoV2 combination as a vaccine adjuvant for Omicron variant of SARS-CoV-2

Can Apical Periodontitis Exacerbate Covid-19 Damage?

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