The circadian clock and diseases of the skin

Duan, Junyan; Greenberg, Elyse Noelani; Karri, Satya Swaroop; Andersen, Bogi

doi:10.1002/1873-3468.14192

Cited by 37 publications

(39 citation statements)

References 174 publications

(301 reference statements)

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“…On the one hand, this is unsurprising given the physical proximity between the layers. On the other, it is unexpected given the well-documented heterogeneity of the skin [34] and tissue-specificity of circadian programs in physiology [7]. Core clock gene expression too was consistent between the layers with rare exceptions.…”

Section: Discussionmentioning

confidence: 99%

Inter-layer and inter-subject variability of circadian gene expression in human skin

Olmo

Spoerl

Korge

et al. 2022

Preprint

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The skin is the largest human organ with a circadian clock that regulates its function. Although circadian rhythms in specific functions are known, rhythms in the proximal clock output, gene expression, in human skin have not been thoroughly explored. This work reports circadian gene expression in two skin layers, epidermis and dermis, in a cohort of young, healthy adults, who maintained natural, regular sleep schedules. 10% of the expressed genes showed rhythms at the population level, of which only a third differed between the two layers. Broadly, expression magnitudes of circadian genes were consistent across subjects in each layer. Amplitude and phases of circadian gene expression, however, varied more across subjects than layers, with amplitude being more variable than phases. Expression amplitudes in the epidermis were larger and more subject-variable, while they were smaller and more consistent in the dermis. Core clock gene expression was similar across layers at the population-level, but were heterogeneous in the their variability across subjects. We used this data to identify small sets of biomarkers for internal clock phase in each layer, which consisted of layer-specific non-core clock genes. This work provides a valuable resource to advance our understanding of human skin to realize the potential of circadian medicine as well as a novel methodology to quantify sources of variability in human circadian rhythms.

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Section: Discussionmentioning

confidence: 99%

Inter-layer and inter-subject variability of circadian gene expression in human skin

Olmo

Spoerl

Korge

et al. 2022

Preprint

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“…Table 5 [123][124][125][126][127][128][129][130][131][132][133][134][135][136] illustrates examples of NCDs and other disorders that are intimately connected to a disruption in circadian rhythms. Because of the tight interconnects that exist between the circadian clock, the microbiome, and systems biology homeostasis or dysbiosis, it is sometimes difficult to distinguish what elements are actually the penultimate controllers.…”

Section: Circadian Rhythmsmentioning

confidence: 99%

Using Microbiome-Based Approaches to Deprogram Chronic Disorders and Extend the Healthspan following Adverse Childhood Experiences

Dietert

Dietert²

2022

Microorganisms

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Adverse childhood experiences (ACEs), which can include child trafficking, are known to program children for disrupted biological cycles, premature aging, microbiome dysbiosis, immune-inflammatory misregulation, and chronic disease multimorbidity. To date, the microbiome has not been a major focus of deprogramming efforts despite its emerging role in every aspect of ACE-related dysbiosis and dysfunction. This article examines: (1) the utility of incorporating microorganism-based, anti-aging approaches to combat ACE-programmed chronic diseases (also known as noncommunicable diseases and conditions, NCDs) and (2) microbiome regulation of core systems biology cycles that affect NCD comorbid risk. In this review, microbiota influence over three key cyclic rhythms (circadian cycles, the sleep cycle, and the lifespan/longevity cycle) as well as tissue inflammation and oxidative stress are discussed as an opportunity to deprogram ACE-driven chronic disorders. Microbiota, particularly those in the gut, have been shown to affect host–microbe interactions regulating the circadian clock, sleep quality, as well as immune function/senescence, and regulation of tissue inflammation. The microimmunosome is one of several systems biology targets of gut microbiota regulation. Furthermore, correcting misregulated inflammation and increased oxidative stress is key to protecting telomere length and lifespan/longevity and extending what has become known as the healthspan. This review article concludes that to reverse the tragedy of ACE-programmed NCDs and premature aging, managing the human holobiont microbiome should become a routine part of healthcare and preventative medicine across the life course.

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“…Pharmacological use of glucocorticoid receptor agonists, coupled with judicious administration times in an asthma model, were shown to minimize phase shifting in the expression of key clock genes, and thus of their clock-dependent proteins [58], providing an avenue to couple DS to circadian control of MC activity. It is important to stress that administration in vivo of such clock modifiers still necessitates a minimum of 2 h for the PER2 upregulation to be observed [59]. Pharmacological resetting of the circadian clock in mast cells and basophils to suppress IgE-mediated allergic reactions has also been demonstrated for compounds such as aminophylline or PF670462 in both animal models and patients [54].…”

Section: Circadian Clock Modulation Of Ige Reactionsmentioning

confidence: 99%

Temporal Modulation of Drug Desensitization Procedures

Stan

2022

CIMB

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Drug hypersensitivity reactions are an unavoidable clinical consequence of the presence of new therapeutic agents. These adverse reactions concern patients afflicted with infectious diseases (e.g., hypersensitivity to antibiotics), and with non-infectious chronic diseases, such as in cancers, diabetes or cystic fibrosis treatments, and may occur at the first drug administration or after repeated exposures. Here we revise recent key studies on the mechanisms underlying the desensitization protocols, and propose an additional temporal regulation layer that is based on the circadian control of the signaling pathway involved and on the modulation of the memory effects established by the desensitization procedures.

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The circadian clock and diseases of the skin

Cited by 37 publications

References 174 publications

Inter-layer and inter-subject variability of circadian gene expression in human skin

Inter-layer and inter-subject variability of circadian gene expression in human skin

Using Microbiome-Based Approaches to Deprogram Chronic Disorders and Extend the Healthspan following Adverse Childhood Experiences

Temporal Modulation of Drug Desensitization Procedures

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