The Circadian Body Temperature Rhythm in the Elderly: Effect of Single Daily Melatonin Dosing

Gubin, Denis; Губин, Г. Д.; Waterhouse, Jim; Weinert, Dietmar

doi:10.1080/07420520600650612

Cited by 57 publications

(35 citation statements)

References 58 publications

(75 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Sources of individual variation are unclear, but limited evidence indicates that the level and variation in amplitude of body temperature decline in late life, possibly due to lower activity, shorter sleep cycle, and/or chronic disease and/or its treatment (Weinert 2010). Studies of active well elderly however do not observe a lower amplitude (Gubin et al 2006), and sex-related differences may reflect dissimilar physical activity behavior (Gubin et al 2006). It is thought that the nadir best reflects the basal set point (Kelly 2006) which, in turn, may best reflect health-related attributes as both caloric restriction and athletic conditioning (Shvartz et al 1974;McLellan 2001;Baum et al 1976) appear to lower basal temperature.…”

Section: Introductionmentioning

confidence: 99%

Basal body temperature as a biomarker of healthy aging

Simonsick

Meier

Shaffer

et al. 2016

AGE

View full text Add to dashboard Cite

Scattered evidence indicates that a lower basal body temperature may be associated with prolonged health span, yet few studies have directly evaluated this relationship. We examined cross-sectional and longitudinal associations between early morning oral temperature (95.0-98.6°F) and usual gait speed, endurance walk performance, fatigability, and grip strength in 762 non-frail men (52 %) and women aged 65-89 years participating in the Baltimore Longitudinal Study of Aging. Since excessive adiposity (body mass index ≥35 kg/m 2 or waist-to-height ratio ≥0.62) may alter temperature set point, associations were also examined within adiposity strata. Overall, controlling for age, race, sex, height, exercise, and adiposity, lower temperature was associated with faster gait speed, less time to walk 400 m quickly, and lower perceived exertion following 5-min of walking at 0.67 m/s (all p ≤ 0.02). In the nonadipose (N = 662), these associations were more robust (all p ≤ 0.006). Direction of association was reversed in the adipose (N = 100), but none attained significance (all p > 0.22). Over 2.2 years, basal temperature was not associated with functional change in the overall population or non-adipose. Among the adipose, lower baseline temperature was associated with greater decline in endurance walking performance (p = 0.006). In longitudinal analyses predicting future functional performance, low temperature in the non-adipose was associated with faster gait speed (p = 0.021) and less time to walk 400 m quickly (p = 0.003), whereas in the adipose, lower temperature was associated with slower gait speed (p = 0.05) and more time to walk 400 m (p = 0.008). In older adults, lower basal body temperature appears to be associated with healthy aging in the absence of excessive adiposity.

show abstract

Section: Introductionmentioning

confidence: 99%

Basal body temperature as a biomarker of healthy aging

Simonsick

Meier

Shaffer

et al. 2016

AGE

View full text Add to dashboard Cite

show abstract

“…Aging is typically associated with (1) an increased fragmentation into shorter alternating periods of rest and activity; (2) an increased activity level during the major sleep period, (3) a decreased activity level during the major active period, and as a consequence (4) a decreased amplitude (Witting et al, 1990;Myers and Badia, 1995;Huang et al, 2002). The amplitude, pattern and phasing of the 24-hour profile of body temperature also changes with aging (Monk et al, 1995;Duffy et al, 1998;Gubin et al, 2006). However, some of the agerelated changes can be ameliorated by increasing the exposure to artificial bright light .…”

Section: Introductionmentioning

confidence: 99%

Attenuated effect of increased daylength on activity rhythm in the old mouse lemur, a non-human primate

Aujard

Cayetanot

Terrien

et al. 2007

Experimental Gerontology

View full text Add to dashboard Cite

To cite this version:Fabienne Aujard, Florence Cayetanot, Jérémy Terrien, Eus J.W. Van Someren. Attenuated effect of increased daylength on activity rhythm in the old mouse lemur, a non-human primate. Experimental Gerontology, Elsevier, 2007, 42 (11) ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T ABSTRACTAdaptation of physiological and behavioral functions to seasonal changes in daylength is of major relevance for optimal fitness and survival. Because aging is characterized by changes in biological rhythms, it may be hypothesized that old animals fall short of showing a full adaptation to prolonged changes in the duration of daily light exposure, as naturally occurring in relation to season in younger individuals. To test this hypothesis, we analyzed changes in the patterns of daily locomotor activity and body temperature rhythms of young and old mouse lemurs (Microcebus murinus, Primates) exposed to short and long daylengths. The effect of an increase in the duration of daily light exposure was attenuated in old animals, as compared to younger lemurs. Although some age-related differences in the locomotor activity rhythm could be seen under exposure to short daylength, they were predominant under long daylength. Some mechanisms allowing adaptation to changing day length thus seem to be impaired at old age. Changes in coupling of circadian oscillators to the light-dark cycle and disturbances in the physiological responses to change in light duration should be further investigated.

show abstract

“…So, the diurnal difference observed for the asymptotic value indicates that thermoregulatory mechanisms in response to exercise are less efficient during the morning session that may be due to the heat gain mode in the morning which may tend to enhance heat storage. As previously discussed by Morris et al (2009), the reported discrepancies could be explained by time of day testing (Waterhouse et al, 2004(Waterhouse et al, , 2005, physical fitness (Atkinson et al, 1993), age (Gubin et al, 2006), and perhaps measurement site, due to local warming.…”

Section: Discussionmentioning

confidence: 72%