The chromosomes in hematology

Berger, Roland

doi:10.1016/0165-4608(81)90010-8

Cited by 22 publications

(2 citation statements)

References 130 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reasons for the greater tumorigenicity of heteroploid and pseudodip loid cell lines are not yet understood. Karyo type studies lead us to suggest that upon close examination, many successfully transplanted diploid cell lines may also have abnormal karyotypes; heteroploidy may provide a pro liferative advantage [17,18]. Perhaps aneuploid cell lines are more able to resist or escape the NK-cclI-mcdiated radiosensitive tumor surveillance mechanisms of nude mice [ 19], The mechanism through which NK cells recognize and destroy targets still remains unclear, but the release of tumor cell prod ucts, the turnover of surface-associated deter minants and the rate of their shedding into the perilumor environment are all important parameters [ 19.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Karyotype of Tissue Culture Lines and Tumorigenicity in Nude Mice

Gershwin

Lentz

Owens³

1984

Pathobiology

View full text Add to dashboard Cite

There are many factors, other than the absence of an immune response, that are responsible for the successful transplantation of xenografts to nude mice. We have defined, in this study, the relationship between karyotype and transplantability of xenografts into nude mice, using a library of 85 tumor and normal tissue culture lines. Each of these lines had been previously passaged in tissue culture for more than 10 generations. 53 of these 85 lines were classified as diploid, whereas 32 lines were classified as heteroploid. These tissue culture lines were transplanted to groups of 4-10 unmanipulated and antilymphocyte serum (ALS)-treated nude mice and serially monitored for 12 weeks. Only 19 % of the diploid lines were successfully transplanted into unmanipulated nude mice, and only 30% were successfully transplanted into ALS-treated nude mice. In comparison, 50% of the heteroploid lines were successfully grafted into unmanipulated nude mice, and a total of 60% were successfully transplanted into ALS-treated nude ice. 12 of the 53 diploid lines can be classified as being pseudodiploid on the basis of rearranged chromosomes or other minor karyotype anomalies. 8 of these 12 pseudodiploid lines were successfully transplanted into nude mice, further strengthening the relationship between abnormal karyotype and transplantability. Tumor karyotype is an additional parameter which should be added to the variables involved in the successful transplantation of tumors to nude mice.

show abstract

Section: Discussionmentioning

confidence: 99%

Relationship between Karyotype of Tissue Culture Lines and Tumorigenicity in Nude Mice

Gershwin

Lentz

Owens³

1984

Pathobiology

View full text Add to dashboard Cite

show abstract

“…The existence of comprehensive and up-to-date reviews (Sandberg, 1980;Mitelman and Levan, 1981;Berger, 1981;Rowley and Testa, 1982;Mitelman, 1983), as well as specialized journals (Cancer Genetics and Cytogenetics) should be noted.…”

Section: Page 278mentioning

confidence: 99%

Report of the committee on chromosome rearrangements in neoplasia and on fragile sites

Chapelle¹,

Berger²

1984

Cytogenet Genome Res

View full text Add to dashboard Cite

Morphologic, immunologic, enzymehistochemical and chromosomal analysis of a cell line derived from Hodgkin's disease. Evidence for a B-cell origin of sternberg-reed cells

Poppema

Jong

Atmosoerodjo

et al. 1985

Cancer

View full text Add to dashboard Cite

Cell lines derived from Hodgkin's disease may provide a clue to the nature of Sternberg‐Reed cells. In the current study, the establishment of an Epstein‐Barr‐virus‐negative lymphoblastoid cell line, derived from the pleural fluid of a patient with the nodular sclerosis type of Hodgkin's diseae, is described. The morphologic and immunologic cell marker findings indicate that this cell line is derived from Sternberg‐Reed cells. The immunologic findings and a chromosomal analysis are in agreement with a B‐lymphocyte origin of these cultured cells. Extrapolation of the results to Hodgkin's disease in vivo would indicate that Hodgkin's disease, like most non‐Hodgkin's lymphomas, is the result of B‐cell proliferation.

show abstract

The chromosomes in hematology

Cited by 22 publications

References 130 publications

Relationship between Karyotype of Tissue Culture Lines and Tumorigenicity in Nude Mice

Relationship between Karyotype of Tissue Culture Lines and Tumorigenicity in Nude Mice

Report of the committee on chromosome rearrangements in neoplasia and on fragile sites

Morphologic, immunologic, enzymehistochemical and chromosomal analysis of a cell line derived from Hodgkin's disease. Evidence for a B-cell origin of sternberg-reed cells

Contact Info

Product

Resources

About