“…We also found increased expression of multiple genes involved in DNA repair processes, such as cenpx, xpc, ercc5/6 and rpa1/2 Figure 5A, 5B). Those DNA repair and tumour-suppressor genes are activated by cell cycle checkpoint controllers upon alteration in DNA integrity [49][50][51][52][53] . Finally, we showed that the expression of multiple pro-apoptotic genes (tp53, baxa, casp8, mdm2, mdm4) [54][55][56][57] and p53 target genes (rrm2, ccng1, rps37l sesn1, sesn3) is increased in these same clusters (Figure 5A, 5B).…”