RFC1regulates the expansion of neural progenitors in the developing zebrafish cerebellum
Fanny Nobilleau,
Sébastien Audet,
Sanaa Turk
et al.
Abstract:SummaryDNA replication and repair are basic yet essential molecular processes for all cells.RFC1encodes the largest subunit of the Replication Factor C (RFC), which is a clamp-loader during DNA replication and repair. Intronic repeat expansion inRFC1has recently been associated with so-calledRFC1-related disorders, which mainly encompass late-onset cerebellar ataxias. However, the mechanisms that make certain tissues more susceptible to defects in these universal pathways remain mysterious. In this study, we p… Show more
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