The Chromatin Assembly Factor Subunit FASCIATA1 Is Involved in Homologous Recombination in Plants

Kirik, Angela; Pečinka, Aleš; Wendeler, Edelgard; Reiss, Bernd

doi:10.1105/tpc.106.045088

Cited by 119 publications

(167 citation statements)

References 57 publications

(96 reference statements)

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“…Both fas1 and msi1 mutants possess reduced heterochromatic content and, in general, a less compacted chromatin (Kirik et al, 2006;Schonrock et al, 2006). Also, CAF-1 is necessary to maintain the repressed state of a subset of genes involved in the G2 checkpoint (Endo et al, 2006;Exner et al, 2006;Kirik et al, 2006;Ramirez-Parra and Gutierrez, 2007b). However, instead of a permanent G2 arrest, as it occurs in animal cells, in the absence of CAF-1 plant cells trigger a premature switch to the endoreplication programme (Ramirez-Parra and Gutierrez, 2007b).…”

Section: Cell Cycle Progressionmentioning

confidence: 99%

“…The fas1 and fas2 mutants present hypersensitivity to genotoxic agents and double-strand break-inducing treatments (Endo et al, 2006;Kirik et al, 2006;Ramirez-Parra and Gutierrez, 2007b). These plants show a constitutively increased amount of double-strand breaks and of the expression of G2 DNA damage checkpoint genes, such as RAD51, PARP1 and BRCA1, in association with an increase in the homologous recombination frequency (Endo et al, 2006;Kirik et al, 2006;Schonrock et al, 2006;Ramirez-Parra and Gutierrez, 2007a).…”

Section: Cell Cycle Checkpointsmentioning

confidence: 99%

“…CAF-1 is necessary for the maintenance of heterochromatic patterns, although the mechanism is not known. Both fas1 and msi1 mutants possess reduced heterochromatic content and, in general, a less compacted chromatin (Kirik et al, 2006;Schonrock et al, 2006). Also, CAF-1 is necessary to maintain the repressed state of a subset of genes involved in the G2 checkpoint (Endo et al, 2006;Exner et al, 2006;Kirik et al, 2006;Ramirez-Parra and Gutierrez, 2007b).…”

Section: Cell Cycle Progressionmentioning

confidence: 99%

“…These plants show a constitutively increased amount of double-strand breaks and of the expression of G2 DNA damage checkpoint genes, such as RAD51, PARP1 and BRCA1, in association with an increase in the homologous recombination frequency (Endo et al, 2006;Kirik et al, 2006;Schonrock et al, 2006;Ramirez-Parra and Gutierrez, 2007a). These observations suggest that loss of CAF-1 activity produces defects in chromatin assembly that could lead to genomic instability (Figure 1).…”

Section: Cell Cycle Checkpointsmentioning

confidence: 99%

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Impact of nucleosome dynamics and histone modifications on cell proliferation during Arabidopsis development

et al. 2010

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Eukaryotic chromatin is a highly structured macromolecular complex of which DNA is wrapped around a histone-containing core. DNA can be methylated at specific C residues and each histone molecule can be covalently modified at a large variety of amino acids in both their tail and core domains. Furthermore, nucleosomes are not static entities and both their position and histone composition can also vary. As a consequence, chromatin behaves as a highly dynamic cellular component with a large combinatorial complexity beyond DNA sequence that conforms the epigenetic landscape. This has key consequences on various developmental processes such as root and flower development, gametophyte and embryo formation and response to the environment, among others. Recent evidence indicate that posttranslational modifications of histones also affect cell cycle progression and processes depending on a correct balance of proliferating cell populations, which in the context of a developing organisms includes cell cycle, stem cell dynamics and the exit from the cell cycle to endoreplication and cell differentiation. The impact of epigenetic modifications on these processes will be reviewed here.

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Section: Cell Cycle Progressionmentioning

confidence: 99%

Section: Cell Cycle Checkpointsmentioning

confidence: 99%

Section: Cell Cycle Progressionmentioning

confidence: 99%

Section: Cell Cycle Checkpointsmentioning

confidence: 99%

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Impact of nucleosome dynamics and histone modifications on cell proliferation during Arabidopsis development

et al. 2010

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“…HR repairs DNA single-and doublestrand breaks, and the readily accessible regions of homology are required for its activity (Puchta 2005). Stresses that may change the chromatin structure either via changes in DNA methylation or histone modifications may also result in altered HR frequency (Bilichak et al 2012;Endo et al 2006;Gao et al 2012;Kirik et al 2006;Mirouze et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Changes in homologous recombination frequency in Arabidopsis thaliana plants exposed to stress depend on time of exposure during development and on duration of stress exposure

Rahavi

Kovalchuk

2013

Physiol Mol Biol Plants

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In the past, we showed that exposure to abiotic and biotic stresses changes the homologous recombination frequency (HRF) in somatic tissue and in the progeny. In current work we planned to answer the following question: do stress intensity/duration and time during exposure influence changes in somatic HRF and transgenerational changes in HRF? Here, we tested the effects of exposure to UV-C, cold and heat on HRF at 7, 14, 21 and 28 days post germination (dpg). We found that exposure at 14 and 21 dpg resulted in a higher increase in HRF as compared to exposure at 7 dpg; longer exposure to UV-C resulted in a higher frequency of HR, whereas prolonged exposure to cold or heat, especially at later developmental stages, had almost no effect on somatic HRF. Exposure at 7 dpg had a positive effect on somatic growth of plants; plants exposed to stress at this age had larger leaves. The analysis of HRF in the progeny showed that the progeny of plants exposed to stress at 7 dpg had an increase in somatic HRF and showed larger sizes of recombination spots on leaves. The progeny of plants exposed to UV-C at 7 dpg and the progeny of plants exposed to cold or heat at 28 dpg had larger leaves as compared to control plants. To summarize, our experiments showed that changes in somatic and transgenerational HRF depend on the type of stress plants are exposed to, time of exposure during development and the duration of exposure.

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Plant Cell Growth Signalling and Its Link to Ploidy

Yoshizumi

Breuer

Matsui

et al. 2008

Plant Cell Monographs

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The Chromatin Assembly Factor Subunit FASCIATA1 Is Involved in Homologous Recombination in Plants

Cited by 119 publications

References 57 publications

Impact of nucleosome dynamics and histone modifications on cell proliferation during Arabidopsis development

Impact of nucleosome dynamics and histone modifications on cell proliferation during Arabidopsis development

Changes in homologous recombination frequency in Arabidopsis thaliana plants exposed to stress depend on time of exposure during development and on duration of stress exposure

Plant Cell Growth Signalling and Its Link to Ploidy

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