Impact of nucleosome dynamics and histone modifications on cell proliferation during Arabidopsis development

Abstract

Eukaryotic chromatin is a highly structured macromolecular complex of which DNA is wrapped around a histone-containing core. DNA can be methylated at specific C residues and each histone molecule can be covalently modified at a large variety of amino acids in both their tail and core domains. Furthermore, nucleosomes are not static entities and both their position and histone composition can also vary. As a consequence, chromatin behaves as a highly dynamic cellular component with a large combinatorial complexity beyond DNA sequence that conforms the epigenetic landscape. This has key consequences on various developmental processes such as root and flower development, gametophyte and embryo formation and response to the environment, among others. Recent evidence indicate that posttranslational modifications of histones also affect cell cycle progression and processes depending on a correct balance of proliferating cell populations, which in the context of a developing organisms includes cell cycle, stem cell dynamics and the exit from the cell cycle to endoreplication and cell differentiation. The impact of epigenetic modifications on these processes will be reviewed here.

Phosphoproteome Dynamics Upon Changes in Plant Water Status Reveal Early Events Associated With Rapid Growth Adjustment in Maize Leaves

“…7), which is consistent with the fact that the cell cycle-related changes require extensive epigenetic and transcriptional regulations for achieving cell cycle transitions, as already reported in growing organs of Arabidopsis thaliana plants (33,34). In contrast, the phosphorylation events occurring in carbohydrate metabolism-related proteins, appeared rather as sustainable changes over the whole rehydration time course (Fig.…”

Jasmonate Controls Leaf Growth by Repressing Cell Proliferation and the Onset of Endoreduplication while Maintaining a Potential Stand-By Mode

“…We show here as well that a number of class H2A and H2B histones required for the onset of the S phase (for review, see Desvoyes et al, 2010) are up-regulated in the presence of MeJA in both Col gl1 and aos. For example, the expression of the H2A class histone HTA10, which is down-regulated during development, is induced by Figure 8.…”

Mutations in HISTONE ACETYLTRANSFERASE1 affect sugar response and gene expression in Arabidopsis

“…Histone modification is a reversible method that cells use to control gene expression, with histone acetylation activating expression of specific sets of genes (reviewed in Lauria and Rossi, 2011). Histone modifications, including acetylation and deacetylation, are involved in controlling a wide variety of pathways ranging from hormone, stress, and light responses to mitosis, development, and Agrobacterium-mediated transformation (Xu et al, 2005; Chen et al, 2010; Desvoyes et al, 2010; Servet et al, 2010; Berr et al, 2011; Costas et al, 2011; Grafi, 2011; Magori and Citovsky, 2011; Qiao and Fan, 2011; Yaish et al, 2011; Luo et al, 2012). Of particular interest to this work are previous findings indicating a role for histone acetylation in sugar response.…”