The Chitosan as Dietary Fiber: An in vitro Comparative Study of Interactions with Drug and Nutritional Substances

Rodrigues, Maira R.; Silva, Alexandre de Souza e; Lacerda, Fábio Vieira

doi:10.5772/48311

Cited by 4 publications

(3 citation statements)

References 50 publications

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“…Low dietary intake is associated with complications like irregular bowel moments, constipation, fluctuations in blood glucose levels, rise in cholesterol level and disturbance in normal gut microbe's level. Among these rise in cholesterol level can lead to obese condition which further brings a number of complications like coronary heart disease, type 2 diabetes, hypertension, stroke, dyslipidemia, insulin-resistance, glucose intolerance, metabolic syndrome [30] [31]. Chitin, a major component involved in building exoskeleton of insects, fungi and marine organisms like crustaceans, shrimps etc., is a major dietary fiber similar to cellulose.…”

Section: Dietary Fibrementioning

confidence: 99%

“…The deacetylated form of chitin, chitosan is widely used as dietary supplement. A substance with natural origin and non-toxic in nature that helps in anti-obesity treatments that has been highly recommended to control obesity is chitosan [30]. The mechanism by which chitin and chitosan involved in fat excretion was studied by L-K Han et al They suggested that decrease in intestinal fat absorption is the possible way for increased excretion of dietary fats from the body.…”

Section: Dietary Fibrementioning

confidence: 99%

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Review on Chitosan Intake and Enhancement in Fecal Excretion of Endocrine Disruptors

Ponnusamy

Rekha

Rajagopal

et al. 2021

JPRI

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Chitin is most abundantly found non-digestible carbohydrate similar to cellulose. It has gained a lot of interest in last few years due to its wide range of applications. They are used as an alternative, dietary supplement. Chitin on deacetylation forms chitosan, an active component of chitin. The degree of deacetylation and molecular weight are the factors that elucidate varying degree of biological property of chitosan. The ability of chitosan in fat and lipid excretion has obtained keen eye among various researchers. This property of chitosan is made use in enhancing the elimination of various harmful environmental lipophilic xenobiotics. Endocrine disruptors are a group of environmental pollutants causing various hazardous effects in living system. They are highly lipophilic, persistent and can accumulate in various tissues. Thus correlating the ability of chitosan to increase excretion of fats and lipophilic xenobiotics showed a promising positive outcome.

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Section: Dietary Fibrementioning

confidence: 99%

Section: Dietary Fibrementioning

confidence: 99%

Review on Chitosan Intake and Enhancement in Fecal Excretion of Endocrine Disruptors

Ponnusamy

Rekha

Rajagopal

et al. 2021

JPRI

View full text Add to dashboard Cite

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“…Obese people usually tend to use mineral and vitamin supplements to compensate for their deficiency in the unbalanced diet. To our knowledge, studies on the interaction between chitosan and other supplements are still rare (Rodrigues, Silva, & Lacerda, 2012). Accordingly, the present work was designed to study the potential combined effects of chitosan, calcium, and vitamins A and E supplements against the adverse effects induced by HFD consumption in rats.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative role of a combination of chitosan, calcium, vitamins A and E against high fat diets-induced adverse effects in rats

Ali¹,

Mansour²,

Hassanine³

et al. 2019

JoBAZ

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Background: Chitosan is a promising natural source for controlling obesity. Obese people tend to use supplementary nutrients to compensate for their deficiencies in their diets. The present study aimed to investigate the combined effect of chitosan, calcium, and vitamins A and E supplements against the adverse effects of high-fat diet consumption in rats. Methods: Twenty-five male albino rats were assigned into five equal groups. Control rats were fed standard basal diet (SBD). Another group was fed high-fat diet (HFD) without supplements. The other three groups were fed HFD containing 0, 400, and 800 mg of chitosan per kilogram diet, in presence of calcium and vitamins A and E supplements, daily for 10 weeks. Results: As compared to controls, rats fed HFD without supplements showed significant elevations in body weight gain, feed consumption, relative weights of the heart and liver, serum levels of total cholesterol, triglycerides, low-density lipoprotein cholesterols, very low-lipoprotein triglycerides, urea, creatinine, and malondialdehyde, as well as serum activities of alanine and aspartate aminotransferases, alkaline phosphatase, and creatine kinase. Moreover, significant declines in the relative kidney weight, serum levels of high-density lipoprotein cholesterols, total proteins, albumin, globulin, calcium, vitamins A and E, erythrocyte glutathione content, and superoxide dismutase activity were recorded. Histopathological alterations were observed in rats fed HFD with or without supplements. On contrary, rats fed HFD containing chitosan and supplements showed remarkable improvement in all the studied parameters towards control values, in dose-dependent manner. Conclusion: Chitosan, calcium, and vitamins A and E attenuated the adverse effects caused by HFD intake in rats.

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Fundamentals and Applications of Chitosan

Morin‐Crini

Lichtfouse

Torri

et al. 2019

Sustainable Agriculture Reviews 35

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Chitosan is a biopolymer obtained from chitin, one of the most abundant and renewable material on Earth. Chitin is a primary component of cell walls in fungi, the exoskeletons of arthropods, such as crustaceans, e.g. crabs, lobsters and shrimps, and insects, the radulae of molluscs, cephalopod beaks, and the scales of fish and lissamphibians. The discovery of chitin in 1811 is attributed to Henri Braconnot while the history of chitosan dates back to 1859 with the work of Charles Rouget. The name of chitosan was, however, introduced in 1894 by Felix Hoppe-Seyler. Because of its particular macromolecular structure, biocompatibility, biodegradability and other intrinsic functional properties, chitosan has attracted major scientific and industrial interests from the late 1970s. Chitosan and its derivatives have practical applications in food industry, agriculture, pharmacy, medicine, cosmetology, textile and paper industries, and chemistry. In the last two decades, chitosan has also received much attention in numerous other fields such as dentistry, ophthalmology, biomedicine and bio-imaging, hygiene and personal care, veterinary medicine, packaging industry, agrochemistry, aquaculture, functional textiles and cosmetotextiles, catalysis, chromatography, beverage industry, photography, wastewater treatment and sludge dewatering, and biotechnology. Nutraceuticals and cosmeceuticals are actually growing markets, and therapeutic and biomedical products should be the next markets in the development of chitosan. Chitosan is also the object of numerous fundamental studies. An indication of the widespread exploitation and constantly growing importance of this biopolymer is the total of over 58,625 scientific articles published between 2000 and 2017. In this chapter, after a description of chitosan fundamentals, we highlight selected works on chitosan applications published over the last two decades.

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The Chitosan as Dietary Fiber: An in vitro Comparative Study of Interactions with Drug and Nutritional Substances

Cited by 4 publications

References 50 publications

Review on Chitosan Intake and Enhancement in Fecal Excretion of Endocrine Disruptors

Review on Chitosan Intake and Enhancement in Fecal Excretion of Endocrine Disruptors

Ameliorative role of a combination of chitosan, calcium, vitamins A and E against high fat diets-induced adverse effects in rats

Fundamentals and Applications of Chitosan

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