The Chinese herbal medicine formula FAHF-2 completely blocks anaphylactic reactions in a murine model of peanut allergy

Srivastava, Kamal; Kattan, Jacob D.; Zou, Zhang‐Yu; Li, Jing Hua; Zhang, Libang; Wallenstein, Sylvan; Goldfarb, Joseph; Sampson, Hugh A.; Li, Xiumin

doi:10.1016/j.jaci.2004.10.003

Cited by 204 publications

(159 citation statements)

References 36 publications

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“…Mice fed 24 times the effective daily dose showed no signs of acute toxicity, and no evidence of abnormal liver and kidney functions, or abnormal complete blood test or histology of major organs. [34] Furthermore, our recent extended studies showed that FAHF-2 completely protects against anaphylactic reactions following multiple peanut rechallenges every 1-2 months for at least 6 months (∼1/4 the life expectancy of mice). [35] Since FAHF-2 was given to the mice during peanut sensitization in those previous studies, we recently investigated whether FAHF-2 can induce peanut tolerance in mice with wellestablished PN allergy and found that FAHF-2 can establish tolerance after peanut allergy is established [36] This protection is also persistent (Srivastava et al, unpublished data).…”

Section: Part II Potential Traditional Chinese Medicine Therapy For mentioning

confidence: 98%

“…[33] This therapeutic effect was associated with immunoregulatory effects on Th1-Th2 responses. [34] Furthermore, this formula appears to have a large margin of safety. Mice fed 24 times the effective daily dose showed no signs of acute toxicity, and no evidence of abnormal liver and kidney functions, or abnormal complete blood test or histology of major organs.…”

Section: Part II Potential Traditional Chinese Medicine Therapy For mentioning

confidence: 99%

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Traditional Chinese herbal remedies for asthma and food allergy

Li¹

2007

Journal of Allergy and Clinical Immunology

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The increasing prevalence of allergic diseases in westernized countries is a significant health problem. Curative therapies for these diseases are not available. There are also significant concerns regarding the potential side effects from the chronic use of conventional drugs such as corticosteroids, especially in children. Many patients with chronic allergic conditions seek complementary and alternative medicine (CAM) therapies including traditional Chinese medicines (TCM). This trend has begun to attract interest from the mainstream healthcare providers and scientific investigators, and has stimulated government agencies in the US to provide support and guidance for the scientific investigation of CAM. This effort may lead to improved therapies and better healthcare/patient outcomes. This review presents an update on the most promising Chinese herbal remedies for asthma and food allergy.

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Section: Part II Potential Traditional Chinese Medicine Therapy For mentioning

confidence: 98%

Section: Part II Potential Traditional Chinese Medicine Therapy For mentioning

confidence: 99%

Traditional Chinese herbal remedies for asthma and food allergy

Li¹

2007

Journal of Allergy and Clinical Immunology

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“…[10][11][12][13] Based on the favorable results of the acute and extended phase I studies, [14,15] we performed a multi-center, randomized, double-blind, placebocontrolled phase II clinical trial to assess safety and efficacy in food allergic individuals.…”

Section: Discussionmentioning

confidence: 99%

“…[9] Murine model studies as well as phase I acute and extended trials of FAHF-2 in patients with peanut, tree nut, fish and/or shellfish allergy demonstrated that this formula is safe and well tolerated; and as seen in a murine model of peanut allergy, it has beneficial immunoregulatory effects in vitro. [10][11][12][13][14][15] Therefore, the aim of this study was to examine the safety and efficacy of FAHF-2 for the treatment of food allergy in a multi-center, randomized, double-blind, placebo-controlled clinical trial. Based on previously published data, we proposed that the therapeutic effect of FAHF-2 on food allergy is due to prevention of IgE triggered mast cell/basophil activation and suppression of Th2 cell cytokine production.…”

Section: Introductionmentioning

confidence: 99%

Safety, Clinical and Immunologic Efficacy of a Chinese Herbal Medicine (FAHF-2) for Food Allergy

Wang¹,

Jones²,

Pongracic³

et al. 2015

Journal of Allergy and Clinical Immunology

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“…The Chinese herbal medicine FAHF-2 has attracted attention as an allergen non-specific therapy for food allergy [87] FAHF-2, a tablet form of a 9-herb extract (Prunus mume, Zanthoxylum schinifolium, Angelica sinensis, Zingiber officinalis, Cinnamomum cassiae, Phellodendron chinense, Coptis chinensis, Panax ginseng and Ganoderma Lucidum) has been shown to completely eliminate PN-induced anaphylaxis in murine food allergy models and has an excellent safety profile in humans [88,89]. Protection persists for up to 6 months following therapy in mice (half of the murine life span) and is associated with sustained reduction of serum PN-IgE levels.…”

Section: Chinese Herbs Food Allergy Herbal Formula-2mentioning

confidence: 99%

The Potential of Maternal Dietary Modification for Prevention of Food Allergy

Luengo¹,

Song²

2013

J Aller Ther

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Effective primary preventions strategies aimed at reducing the onset of IgE sensitization are urgently needed as the incidence of childhood food allergy keeps increasing.Studies eliminating food allergens during pregnancy have failed to show reduction in the prevalence of long-term IgE-mediated food allergy in children, and recent data provides direct evidence supporting early oral exposure as a means of preventing development of allergy. Since effects on early immune programming may be more significant in utero, there has been increasing interest in the potential protective role of maternal dietary modifications on the development of FA in offspring.In this article, we will review the current knowledge from animal and clinical studies on the role of maternal dietary modification, mainly through supplementation with vitamins, polyunsaturated fatty acids and probiotics, for the prevention of food allergy. Besides, the potential role of some promising FA treatments like Chinese herbal formula FAHF-2 for the primary prevention of FA in offspring will be reviewed. be due to uncontrolled environmental factors, timing of introduction to PN and different study protocols and populations, as well as undefined co-factors in maternal diet such as microbes [18][19][20]. In addition, retrospective maternal recall of dietary intake during pregnancy (and or lactation), sometimes months or years later, may contain recall bias. At present, the standard practice for PNA and other food allergies is strict allergen avoidance. There is no clinical study reporting whether peanut allergic mother consumption of controlled low doses of peanut that do not trigger clinical reactions would prevent offspring peanut or other food allergies. The Potential of Maternal Dietary Modification for Prevention of Food AllergyOlga Maternal allergenic food consumption for preventing food allergy in offspring: Animal studiesIn recent years several studies in animal models have provided direct evidence supporting early oral exposure as a means of preventing development of allergy.Melkild et al. [21] showed that intraperitoneal immunization of naïve mice with ovalbumin and adjuvant (Al(OH) 3 ) during pregnancy and lactation significantly reduced the specific IgE response and increased the IgG2a response in their offspring. Moreover, the IgE suppression was stronger if maternal allergen exposure was during early pregnancy (3 days into pregnancy) compared to a late pregnancy exposure (17 days into pregnancy). The same group reported that the protective effect of maternal immunization was affected by the type of adjuvant used: while offspring from mothers immunized with OVA and either pertussis toxin (PT) or Al(OH) 3 showed reduced levels of OVA-specific IgE and IgG1 and increased levels of OVA-specific IgG2a antibodies, maternal immunization with CpG and OVA did not affect antibody responses in offspring [22]. However, whether this effect is dependent on the specific adjuvant and/or the route of exposure employed has to be further investigated. Le...

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The Chinese herbal medicine formula FAHF-2 completely blocks anaphylactic reactions in a murine model of peanut allergy

Cited by 204 publications

References 36 publications

Traditional Chinese herbal remedies for asthma and food allergy

Traditional Chinese herbal remedies for asthma and food allergy

Safety, Clinical and Immunologic Efficacy of a Chinese Herbal Medicine (FAHF-2) for Food Allergy

The Potential of Maternal Dietary Modification for Prevention of Food Allergy

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