Safety, Clinical and Immunologic Efficacy of a Chinese Herbal Medicine (FAHF-2) for Food Allergy

Wang, Julie; Jones, Stacie M.; Pongracic, Jacqueline A.; Song, Ying; Yang, Nan; Sicherer, Scott H.; Makhija, Melanie; Robison, Rachel G.; Moshier, Erin; Godbold, James; Sampson, Hugh A.; Li, Xiumin

doi:10.1016/j.jaci.2014.12.1700

Cited by 2 publications

(1 citation statement)

References 29 publications

(42 reference statements)

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“…Food allergy is estimated to affect 5% of adults and 8% of young children ; the prevalence of food allergy has been increasing signi cantly in the recent decades. [1][2] Food allergy have become a worldwide health problem, which burdens patients and families by increasing expenses of healthcare and negatively affects the quality of life.…”

Section: Introductionmentioning

confidence: 99%

HDM exposure enhances subsequent responses to OVA-induced food allergy

Lin

Chen

Chang

et al. 2021

Preprint

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HDM (House dust mites) are important environmental trigger factors of airway allergic diseases, the allergens of HDM were detected in the human gut mucosa, which induces local inflammation and increases intestinal permeability. This study tests a hypothesis that house dust mites contribute to the development of OVA (ovalbumin)-induced food allergy. The serum levels of IgE against HDM in patients with food allergy were detected with UniCAP100 (Pharmacia, Uppsala, Sweden); the HDM-induced/the OVA-induced mouse model of food allergy was developed. Difference between 2 groups was determined by Student t test or ANOVA if more than two groups. Compared to the healthy controls, the patients with food allergy have higher levels of serum IgE against HDM. Compared to food allergy alone groups, the levels of IgE against HDM in food allergy with asthma or allergic rhinitis groups were increased significantly. In mouse models, we found that HDM/OVA induced allergy-like symptoms, lower body temperature, and lower body weight. The levels of IgE, IgG1, mMCP-1 (mouse mast cell protease-1), IL-4 and IL-5 in the HDM and HDM + CT (cholera toxin) groups were higher than the control groups, and the levels of IgE, IgG1, IL-4 and IL-5 in the HDM, OVA and HDM + OVA groups were higher than the control groups. The pathology of intestinal tract in the HDM and HDM + CT/the HDM, OVA and HDM + OVA groups were more severe and exhibited more eosinophils than the control groups. Moreover, the prior exposure to HDM induced intestinal barrier dysfunction, and facilitated the development of intestinal allergy in mice. Based on above data and previous researches, we put forward that HDM exposure enhances subsequent responses to OVA-induced food allergy.

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Section: Introductionmentioning

confidence: 99%

HDM exposure enhances subsequent responses to OVA-induced food allergy

Lin

Chen

Chang

et al. 2021

Preprint

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Current Options for the Treatment of Food Allergy

Lanser

Wright

Orgel

et al. 2015

Pediatric Clinics of North America

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Food allergy is increasing in prevalence; as a result, there is intense focus on developing safe and effective therapies. Current methods of specific immunotherapy include oral, sublingual, and epicutaneous, while nonspecific methods that have been investigated include: Chinese herbal medicine, probiotics, and anti-IgE antibodies. Although some studies have demonstrated efficacy in inducing desensitization, questions regarding safety and the potential for achieving immune tolerance remain. Although some of these therapies demonstrate promise, further investigation is required before their incorporation into routine clinical practice.

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Safety, Clinical and Immunologic Efficacy of a Chinese Herbal Medicine (FAHF-2) for Food Allergy

Cited by 2 publications

References 29 publications

HDM exposure enhances subsequent responses to OVA-induced food allergy

HDM exposure enhances subsequent responses to OVA-induced food allergy

Current Options for the Treatment of Food Allergy

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