Current Options for the Treatment of Food Allergy

Lanser, Bruce J.; Wright, Benjamin L.; Orgel, Kelly; Vickery, Brian P.; Fleischer, David M.

doi:10.1016/j.pcl.2015.07.015

Cited by 36 publications

(31 citation statements)

References 71 publications

(71 reference statements)

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“…Researchers have devoted their eforts for many years to the development of efective and safe strategies for the treatment of allergy to alleviate the symptoms triggered by the body's responses to allergens [1,13,14]. Antihistamines are currently the most commonly used treatment.…”

Section: Antihistaminic Treatmentmentioning

confidence: 99%

“…ASIT consists of the gradual administration of doses of a speciic allergen or part of that allergen to reduce the sensitivity and consequently to decrease the symptomatic reactions to a future exposure of the allergic individual to the causative natural agent [1,18]. ASIT is a widely used therapeutic strategy for treating allergic rhinitis, venom-induced hypersensitivity, some drug allergies, and mild bronchial asthma [13].…”

Section: Allergen-speciic Immunotherapy (Asit)mentioning

confidence: 99%

“…The mechanisms of ASIT are not yet clear but include modulating both T and B cell responses, thereby reducing the incidence and severity of IgE-mediated adverse reactions [19]. Some of the immunological changes that occur during ASIT have been elucidated [1]. ASIT increases the level of allergen-speciic IgA and IgG4 antibodies and decreases the level of allergen-speciic IgE antibodies.…”

Section: Allergen-speciic Immunotherapy (Asit)mentioning

confidence: 99%

“…Anti-IgE therapy is most commonly used to treat bronchial asthma but is also efective for treating allergic rhinoconjunctivitis, but therapy must begin before the pollen season [26]. The anti-IgE therapy is currently being studied for use in food allergies, but the cost has limited its use for this purpose [1].…”

Section: Anti-ige Receptor Antibodiesmentioning

confidence: 99%

“…An allergy is commonly deined as an immediate or type I hypersensitivity reaction where symptoms appear rapidly and are caused by exposure to exogenous macromolecules known as antigens or allergens. The hypersensitivity reaction has two phases: sensitization, when the subject is irst exposed to the antigen, and the subsequent reaction, when the subject is again exposed to the antigen [1]. The irst sensitization of a body begins with the irst contact with an antigen, which induces an allergy.…”

mentioning

confidence: 99%

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Antihistaminic Treatment, Allergen‐Specific Immunotherapy, and Blockade of IgE as Alternative Allergy Treatments

Machado¹,

Campos‐Mesquita²,

Pacheco-Soares³

2017

Allergen

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Allergies mediated by immunoglobulin E (IgE) are the most common immunological hypersensitivity diseases. The prevalence has been continuously increasing in recent decades, and more than 25% of the population is currently afected. Symptoms of allergies can be observed in the skin and respiratory and gastrointestinal tracts, and systemic manifestations include anaphylactic shock. If an allergy is not properly diagnosed and treated, it tends to progress to a severe and chronic debilitating disease. Understanding the mechanisms by which the immune system induces and controls allergic inlammation depends on knowing the structure of several allergens and identifying epitopes, which are critical for the design of new strategies for treating allergies. Strategies for immunotherapy will be reviewed. Allergen-speciic immunotherapy has been used for nearly a century and remains one of the few antigen-speciic treatments for inlammatory diseases. There is a strong rationale for improving the eicacy of allergen-speciic immunotherapy by reducing the incidence and severity of adverse reactions mediated by IgE. Approaches to address this problem, including the use of modiied allergens, synthetic peptides as vaccines, and alternative strategies for blocking IgE, will be discussed.

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Section: Antihistaminic Treatmentmentioning

confidence: 99%

Section: Allergen-speciic Immunotherapy (Asit)mentioning

confidence: 99%

Section: Allergen-speciic Immunotherapy (Asit)mentioning

confidence: 99%

Section: Anti-ige Receptor Antibodiesmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Antihistaminic Treatment, Allergen‐Specific Immunotherapy, and Blockade of IgE as Alternative Allergy Treatments

Machado¹,

Campos‐Mesquita²,

Pacheco-Soares³

2017

Allergen

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Prevalence of sensitization to molecular food allergens in Europe: A systematic review

Lisik

Ioannidou

Spolidoro

et al. 2022

Clinical & Translational All

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Background Recent reports indicate that the prevalence of food allergy is increasing, but accurate estimates remain a challenge due to cross‐reactivity and limited use of precise diagnostic methods. Molecular allergy diagnostics, in which sensitization to individual molecular allergens is measured, is emerging as a promising tool for evaluation of sensitization profiles. In this systematic review, we summarized estimates of prevalence of sensitization to molecular food allergens in the general population in Europe. Methods Following a protocol prospectively registered with the International Prospective Register of Systematic Reviews (PROSPERO; reference CRD42021266657), we searched seven databases with no restrictions on publication date or language. Two reviewers independently screened the literature, extracted data, and appraised the risk of bias in the included studies. The findings were synthesized narratively. Results From 4776 de‐duplicated records, five studies, with low to moderate overall risk of bias, were included. Forty‐six molecular allergens from 18 foods were investigated. Overall, the prevalence of sensitization was low, particularly for major allergens, and non‐existent for 10 molecular allergens (0% [95% CI 0–0.8]). The highest prevalence was seen for PR‐10 proteins, such as Cor a 1.04 (13.6% [95% CI 10.9–16.9]). Conclusions Available data, primarily from North‐western Europe, indicate that sensitization to molecular food allergens is overall low. The highest estimates were found for cross‐reactive PR‐10 proteins. There were not enough studies to discern regional differences or perform meta‐analysis, highlighting the need for more population‐representative studies in order to elucidate patterns of sensitization to molecular food allergens in Europe.

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The Use of Omalizumab in Food Oral Immunotherapy

Labrosse

Graham

Roches

et al. 2016

Arch. Immunol. Ther. Exp.

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Food allergy is an important health issue that affects up to 8 % of the population. The management of allergic patients involves allergen avoidance and prompts the treatment of accidental reactions, as no curative treatment is available so far in routine practice. Oral immunotherapy (OIT) is a promising therapeutic alternative, but it is associated with frequent allergic reactions and cost-effectiveness issues. In hopes of reducing such reactions, a number of trials have used omalizumab, an anti-IgE monoclonal humanized antibody, as adjunctive therapy in OIT. The allergens studied in these omalizumab-enabled OIT trials include peanuts, milk, eggs, or mixes of multiple foods. In this article, we review the major findings from these studies and discuss potential benefits and issues related to omalizumab-enabled OIT. Results from the previous trials suggest that the use of omalizumab could potentially lead to safer and more efficient OIT protocols, by reducing the number and severity of reactions, and increasing allergen tolerance threshold. While more evidence is needed with regard to the maintenance of the long-term tolerance after OIT, omalizumab's potential immunomodulatory role could be of benefit. More studies are needed to further document this new indication for omalizumab.

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Current Options for the Treatment of Food Allergy

Cited by 36 publications

References 71 publications

Antihistaminic Treatment, Allergen‐Specific Immunotherapy, and Blockade of IgE as Alternative Allergy Treatments

Antihistaminic Treatment, Allergen‐Specific Immunotherapy, and Blockade of IgE as Alternative Allergy Treatments

Prevalence of sensitization to molecular food allergens in Europe: A systematic review

The Use of Omalizumab in Food Oral Immunotherapy

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