The Chemotherapy of Intestinal Nematodes

McFarland, James W.

doi:10.1007/978-3-0348-7081-8_3

Cited by 4 publications

(3 citation statements)

References 127 publications

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“…Wundt during the years 1872-1878 [25]. Although the discovery of benzimidazole was early, the investigation of the effectiveness of this compound and its effective therapeutic potential for parasites was not noticed until 80 years after its discovery, when the compound consisting of 2-phenylbenzimidazole with phenothiazine was prepared, which turned out to be an anthelmintic sheep in the early sixties [26]. In 1961, the compound 2-(thiazol-4-yl)benzimidazole was discovered in the laboratories of Merck Sharp & Dohme, where the prepared compound was considered a broadspectrum and very important antihelminthic [27].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications

Alheety,

Mohammed,

Farhan

et al. 2023

SynOpen

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Benzimidazole is a heterocyclic compound formed by fusing the benzene ring with an imidazole ring that contains two nitrogen atoms. Benzimidazole and its derivatives are prepared in different ways, including condensation of o-phenylenediamine with carbonyl compounds (aldehydes and ketones) or with carboxylic acids and their derivatives. The benzimidazoles can also be prepared by rearranging other heterocyclic compounds such as quinoxaline derivatives, triazole derivatives, etc. In recent decades, benzimidazoles were prepared using green methods such as microwaves, ultrasound, and the use of an environmentally friendly catalyst, as well as photochemical reactions. Benzimidazoles have attracted the interest of scientists and researchers due to the great medical efficacy shown by them for various diseases. The benzimidazole derivatives show many pharmacological activities such as anticancer, anti-inflammatory, antioxidant, anticoagulant, antiviral, etc. This review focuses on shedding light on benzimidazole and its derivatives, the most important methods used to prepare it, as well as the biological applications in our daily lives.

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Section: Accepted Manuscriptmentioning

confidence: 99%

A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications

Alheety,

Mohammed,

Farhan

et al. 2023

SynOpen

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“…Several 2,5-disubstituted benzimidazoles, with proven potentiality to kill various species of intestinal nematodes [266], have also been found to possess activity against cestodiasis of man and animals. Mebendazole (CXL), at a dose of 100 mg/kg given twice daily for 4 days, at 200 mg/kg twice daily for 2 days or at 200 mg/kg twice daily for 4 days gave, respectively, 20, 72.7 and 90% cure rates in 31 patients suffering with T. solium and T. saginata [267].…”

Section: Benzimidazolesmentioning

confidence: 99%

Chemotherapy of cestode infections

Sharma¹,

Dubey²,

Iyer³

1980

Progress in Drug Research / Fortschritte Der Arzneimittelforschung / Progrès Des Recherches Pharmaceutiques

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“…A nitrogen heterocycle benzimidazole was first synthesized by Hoebrecker [1], and after 80 years the therapeutic activity as an anthelmintic drug was recognized [2]. Today, benzimidazoles are the most important anthelmintics serving as effective drugs for intestinal and tissue-dwelling parasites [3].…”

Section: Introductionmentioning

confidence: 99%

Potential Hexokinase II Inhibition by Benzimidazole Anthelmintics: Albendazole, Mebendazole and Fenbendazole

Kim

2021

JPRI

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The nitrogen heterocycle benzimidazoles have been known to be anthelmintic drugs. Beyond that role, the benzimidazoles exhibit other pharmacological potential as anti-inflammatory, antiulcer, anti-hypertensive and anticancer agents. A growing body of evidence supports the anticancer efficiency via treatment with benzimidazoles. The target proteins for pharmacological effect appear to be cell microtubules. However, it has been reported that the benzimidazoles could inhibit hexokinase II, which is a critical factor in the glycolysis pathway in humans. Here, we discuss on the most common benzimidazoles such as albendazole, mebendazole and fenbendazole and focus on the potential anticancer activities of the target enzyme hexokinase II. This review would give better insight in development of target-specific benzimidazole derivatives as potential anticancer therapeutics.

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The Chemotherapy of Intestinal Nematodes

Cited by 4 publications

References 127 publications

A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications

A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications

Chemotherapy of cestode infections

Potential Hexokinase II Inhibition by Benzimidazole Anthelmintics: Albendazole, Mebendazole and Fenbendazole

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