Chemotherapy of cestode infections

Sharma, Satyavan; Dubey, Shikha; Iyer, R. N.

doi:10.1007/978-3-0348-7108-2_5

Cited by 4 publications

(4 citation statements)

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“…Route E (Compounds 63, 65-69,72, and 73). A mixture of 0.01 mol of the appropriate benzoxazole (62, 64, or 71), 0.01 mol of NBS, and 0.1 g of azobisbutyronitrile in 100 mL of CHC13 was refluxed for 36-48 h. An additional 0.1 g of azobisbutyronitrile was added every 12 h. The reaction mixture was cooled to room temperature, and the precipitated succinimide was filtered off. The CHC13 solution was washed with 5% NaOH, dried, and evaporated in vacuo.…”

Section: Methodsmentioning

confidence: 99%

“…Thus, a variety of 2-substituted benzoxazoles have been claimed to possess antiparasitic activity against Turbatrix aceti4 Syphacia obvelata,5 Nippostronglyus brasiliensis,6 helminths, 7,8 Eimeria tenella and Eimeria necatrix,9 and S. obvelata and Aspicularis tetraptera.10 Brenneisen and co-workers describe anthelmintic isothiocyanatobenzoxazoles,11 and Sharma's review summarizes cestocidal isothiocyanates. 12 Furthermore, several papers and patents describe antiparasitic 2-substituted benzothiazoles active against Nematospiroides dubius,13 Ascaris suum,14 and Hymenolepis nana. 15 Ciba-Geigy patents disclose isothiocyanatobenzoxazoles as anthelmintics.…”

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confidence: 99%

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Antiparasitic agents. 5. Synthesis and anthelmintic activities of novel 2-heteroaromatic-substituted isothiocyanatobenzoxazoles and -benzothiazoles

Haugwitz¹,

Angel²,

Jacobs³

et al. 1982

J. Med. Chem.

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The synthesis and antiparasitic properties of 22 isothiocyanato-2-pyridinylbenzoxazoles and benzothiazoles are described; the preparation and anthelmintic activities of 14 isothiocyanato-2-thienyl-, -furyl-, and -pyrrolylbenzoxazoles are outlined. In mice experimentally infected with Nematospiroides dubius (nematode) and Hymenolepis nana (tapeworm), three derivatives, i.e., 5-isothiocyanato-2-(2-furyl)benzoxazole (34), 5-isothiocyanato-2-(5-methyl-2-furyl)benzoxazole (35), and 5-isothiocyanato-2-(1-methyl-1H-2-pyrroly)benzoxazole (37), show 100% nematocidal activity and two, i.e., 5- and 6-isothiocyanato-2-(3-pyridinyl)benzoxazole (5) and 5- and 6-isothiocyanato-2-(3-pyridinyl)benzthiazole (21), show 10% taeniacidal activity at 0.2% in the diet. Two derivatives (5 and 21) show good nematocidal activity in sheep. Maximum activity requires 3-pyridinyl derivatives for both the benzoxazole and benzothiazole series.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Antiparasitic agents. 5. Synthesis and anthelmintic activities of novel 2-heteroaromatic-substituted isothiocyanatobenzoxazoles and -benzothiazoles

Haugwitz¹,

Angel²,

Jacobs³

et al. 1982

J. Med. Chem.

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“…The spectra of complexes [2][3][4][5][6][7][8][9], showed the v(C=O) within (1636-1662) cm -1 range, is higher than from the v(C=O) of complex (1) (1624) cm -1 , which suggest that the carbonyl group are non-involved in coordination to Hg ion [18][19][20], and suggesting a monodentate of (Saln -) ligand through oxygen atom of the deprotonated hydroxyl group [16][17][18][19][20]. The spectra 2-9 displayed new bands at (1435-1450) cm -1 and (498-513) cm -1 range assigned to v(P-Ph) and v(P-C) [21][22][23], indicating the presence of the phosphine ligands in the complexes.…”

Section: Scheme 2: Preparation Of Complexes (2-9)mentioning

confidence: 99%

“…The salicylanilide compounds have been widely used to treat intestinal tapeworm, hydatid diseases, schistosomiasis, liver fluke infection in human and animals [3]. In veterinary medicine, the salicylanilides derivatives (such as niclosamide, terenol, oxyclozanide, rafoxanide, and clioxanide) are used to treat tapeworm and flake infections from domestic animals [4][5][6][7][8] . HSaln ligand can be showed different coordination fashion to metal ions, being act as monodentate fashion through the oxygen atom of deprotonated hydroxyl group, or through the neutral oxygen of hydroxyl or carbonyl group, and it also has the ability to bonding as a bidentate fashion through oxygen and nitrogen donor atom [9].…”

Section: Introductionmentioning

confidence: 99%

New Salicylanilide-Hg(II) complexes with phosphine ligands, Synthesis and spectroscopic investigation

Al-Doori¹,

Al‐Janabi²

2019

Tikrit J. Pure Sci.

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A new complex of the type [Hg(k2-Saln)2] (1) was prepared from the reaction of mercury acetate and salicylanilide (HSaln) in (1:2) molar ratio EtOH as a solvent with presence an Et3N as a base. Treatment of complex (1) with diphosphine {where diphos: dppe, dppp, dppb dppf and dppmS2} in 1:1) (complex: diphos) molar ratio afforded a complexes of the types [Hg(k1-Saln)2(diphos)] (2-6),where as a complexes of the types [Hg(k1-Saln)2(phos)2] (7,8) when treatment of complex(1) with two moles of monophosphine (PPh3 or SPPh3). The prepared complexes were fully characterization by many technical such as elemental analysis, molar conductivity, infrared spectroscopy, and nuclear magnetic resonance (1H and 31P). In complex (1) the (Saln-) was bonded as bidentate chelating ligand through the oxygen atoms of the carbonyl and deprotonated hydroxyl group, whereas bonded as monodentate ligand through the oxygen atom of deprotonated hydroxyl group in all other complexes (2-8). The geometry of the complexes (1-8) is a tetrahedral around the mercury (II) ion.

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