The chemopreventive action of bromelain, from pineapple stem (<i><scp>A</scp>nanas comosus</i><scp>L</scp>.), on colon carcinogenesis is related to antiproliferative and proapoptotic effects

Romano, Barbara; Fasolino, Ines; Pagano, Ester; Capasso, Raffaele; Pace, Simona; Rosa, Giuseppe De; Milić, Nataša; Orlando, Pierangelo; Izzo, Angelo A.; Borrelli, Francesca

doi:10.1002/mnfr.201300345

Cited by 55 publications

(49 citation statements)

References 37 publications

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“…Raw extracts obtained from mango (Kim et al ., ; Noratto et al ., ; Banerjee et al ., ), papaya (Gayosso‐García Sancho et al ., ; Nguyen et al ., ; Sancho et al ., ) and pineapple (Romano et al ., ; Gani et al ., ) pulps contain different phytochemicals with antiproliferative capacity, chemopreventive and citotoxic effects on different cancer cell lines with no apparent effects on normal cells (Yen et al ., ; Noratto et al ., ; Maisarah et al ., ). Several in vitro and in vivo studies have shown that ascorbic acid (Du et al ., ), polar phenolic compounds (Verma et al ., ; Gómez‐Caravaca et al ., ) and certain lipophilic compounds (Sancho et al ., ; Rascón‐Valenzuela et al ., ; Torres‐Moreno et al ., ) have a strong antiproliferative capacity on different cancer cell lines.…”

Section: Resultsmentioning

confidence: 97%

“…are natural functional foods. They have a vast array of extractable phytochemicals with radical scavenging and antiproliferative capacity that, if eaten in sufficient amounts, may help to prevent breast, ovarian, colon, lung, leukaemia and prostate (García‐Solís et al ., ; Kim et al ., ; Noratto et al ., ; Nguyen et al ., ; Luo et al ., ; Romano et al ., ; Sancho et al ., ; Banerjee et al ., ; Gani et al ., ; Roleira et al ., ; Taing et al ., ) cancers. However, tropical fruits have usually a very short shelf life, which limits their distribution and commercialisation.…”

Section: Introductionmentioning

confidence: 98%

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Radical scavenging and anti‐proliferative capacity of three freeze‐dried tropical fruits

Olivas-Aguirre

González‐Aguilar

Velderrain-Rodríguez

et al. 2017

Int J of Food Sci Tech

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Summary Tropical fruits are rich in antioxidant and anticancer phytochemicals, but their nutraceutical potential could be enhanced by drying technologies. Mango cv. Ataulfo, papaya cv. Maradol and pineapple cv. Esmeralda ripe pulps were freeze‐dried (−42 °C, 0.12 torr, 48 h) and their physicochemical and phytochemical profile, radical scavenging and antiproliferative capacity evaluated. The content of soluble solids, phenolic compounds and ascorbic acid was higher in mango (16.1oBrix, 9.9 mg GAE per g and 9.6 mg g−1) than in papaya/pineapple, but the later had more flavonoids (0.45 ± 0.05 mg QE per g). A fruit‐specific phenolic profile was detected by HPLC‐ESI‐QTOF‐MS, being shikimic (mango), chlorogenic (papaya), and protocatechuic (pineapple) acids the most abundant. Mango was the strongest radical scavenger and showed antiproliferative capacity (IC50, μg mL−1) in RAW 264.7 (100.7), HeLa (193.1) and L929 (138.5) cell lines. Papaya and pineapple extracts showed no antiproliferative activity. Freeze‐dried mango is a ready‐to‐eat functional food with better cancer preventing properties than papaya or pineapple.

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Section: Resultsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

Radical scavenging and anti‐proliferative capacity of three freeze‐dried tropical fruits

Olivas-Aguirre

González‐Aguilar

Velderrain-Rodríguez

et al. 2017

Int J of Food Sci Tech

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“…This distribution will be lost by increasing the inorganic amount (B_HA 20 and B_HA 30 ) probably due to the development of different intensities of interactions among ions. The charge density in the gelatin structure is fixed, demonstrating that the number of nucleation sites is uniformly distributed, and therefore the size/shape of nHA crystalline depend on the rate of crystalline growth, or rather [Ca 2+ ] [

{PO}_{4}^{3 -}

] concentration . Higher [Ca 2+ ] and [

{PO}_{4}^{3 -}

] values lead to the rate of crystalline growth accelerated.…”

Section: Discussionmentioning

confidence: 99%

Gelatin/nano‐hydroxyapatite hydrogel scaffold prepared by sol‐gel technology as filler to repair bone defects

Raucci

Demitri

Soriente

et al. 2018

J Biomedical Materials Res

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This study reports on the development of a scaffold with a gradient of bioactive solid signal embedded in the biodegradable polymer matrix by combining a sol-gel approach and freeze-drying technology. The chemical approach based on the sol-gel transition of calcium phosphates ensures the particles dispersion into the gelatin matrix and a direct control of interaction among COOH /Ca ions. Morphological analysis demonstrated that on the basis of the amount of inorganic component and by using specific process conditions, it is possible to control the spatial distribution of nanoparticles around the gelatin helix. In fact, methodology and formulations were able to discriminate between the different hydroxyapatite concentrations and their respective morphology. The good biological response represented by good cell attachment, proliferation and increased levels of alkaline phosphatase as an indicator of osteoblastic differentiation of human mesenchymal stem cells toward the osteogenic lineage, demonstrating the effect of bioactive solid signals on cellular behavior. Furthermore, the inhibition of reactive oxygen species production by composite materials predicted potential anti-inflammatory properties of scaffolds thus confirming their biocompatibility. Indeed, these interesting biological results suggest good potential application of this scaffold as filler to repair bone defects. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2007-2019, 2018.

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“…Nipah contains a high concentration of minerals and vitamin A and has been used to treat several diseases, such as asthma, tuberculosis, and diabetic and liver diseases . Furthermore, with a high vitamin C content and antioxidant activity, pineapple has exhibited, among several promising properties, anti‐cancer and antihyperglycaemic effects …”

Section: Introductionmentioning

confidence: 99%

Comparison of in vivo toxicity, antioxidant and immunomodulatory activities of coconut, nipah and pineapple juice vinegars

et al. 2017

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Overall, the data suggested that not all vinegar samples cause acute and sub-chronic toxicity in vivo. Moreover, the in vivo immunity and organ antioxidant levels were enhanced, to varying extents, by the phenolic acids present in the vinegars. The results obtained in this study provide appropriate guidelines for further in vivo bioactivity studies and pre-clinical assessments of vinegar consumption. © 2017 Society of Chemical Industry.

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The chemopreventive action of bromelain, from pineapple stem (Ananas comosusL.), on colon carcinogenesis is related to antiproliferative and proapoptotic effects

Abstract: Bromelain exerts antiproliferative and proapoptotic effects in colorectal carcinoma cells and chemopreventive actions in colon carcinogenesis in vivo. Bromelain-containing foods and/or bromelain itself may represent good candidates for colorectal cancer chemoprevention.

Cited by 55 publications

References 37 publications

Radical scavenging and anti‐proliferative capacity of three freeze‐dried tropical fruits

Radical scavenging and anti‐proliferative capacity of three freeze‐dried tropical fruits

Gelatin/nano‐hydroxyapatite hydrogel scaffold prepared by sol‐gel technology as filler to repair bone defects

Comparison of in vivo toxicity, antioxidant and immunomodulatory activities of coconut, nipah and pineapple juice vinegars

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