The Chemistry of Melanotropins

Li, Choh Hao

doi:10.1016/b978-0-12-447205-1.50007-4

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1981

1986

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“…Since none of these seemingly distinct PDHs has been sequenced, their relationship to a-PDH and /3-PDH remains unclear. It is of comparative interest that variation in molecular size as well as differences in net charge are evident among the melanophore-stimulating hormones (MSHs) of vertebrates (Li, 1978;Baker, 1979;Hruby et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

ISOLATION AND SEQUENCE ANALYSIS OF A PIGMENT-DISPERSING HORMONE FROM EYESTALKS OF THE CRAB,CANCER MAGISTER

Kleinholz¹,

Rao²,

Riehm³

et al. 1986

The Biological Bulletin

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The application of separation procedures, including liquid partition, gel nitration, ion-exchange chromatography, partition chromatography, and reversed-phase highperformance liquid chromatography, enabled the purification of an octadecapeptide pigment-dispersing hormone (PDH) from powdered lyophilized eyestalks of the crab, Cancer magister. Automated Edman degradation, followed by the identification of carboxyl-terminal amide, established the sequence of the peptide as: Asn-Ser-Glu-Leu-Ile-Asn-Ser-Ile-Leu-Gly-Leu-Pro-Lys-Val-Met-Asn-Asp-Ala-NH 2 . The characterized Cancer PDH is structurally identical to an octadecapeptide PDH of Uca pugilator, but differs from the PDH of Pandalus borealis at positions 3, 4, 11, 13, 16, and 17.

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Section: Discussionmentioning

confidence: 99%