The Chemistry of Glycogen

Meyer, Kurt H.

doi:10.1002/9780470122488.ch4

Cited by 2 publications

(2 citation statements)

References 43 publications

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“…Extracted particles were subjected to a round of 2D classifications with a mask of 200 Å. Selected particles (264,267) were classified in 3D by limiting the E-step size to 7 Å, regularization parameter T=4 and a mask of 200 Å. The best 3 classes (97,369 particles) were selected and re-extracted with a box size of 256 pixels with no downscaling.…”

Section: Cryo-em Image Processing Of Wild-type Opua In 100 MM Kclmentioning

confidence: 99%

“…However, the glycogen metabolism itself also contributes to the cell's osmotic pressure. Sequestering glucose in a very large and dense polymer is a very efficient way to reduce the glucose-induced osmotic pressure [267]. Therefore, it makes sense to regulate glycogen turnover and the degree of branching in the context of cell volume regulation.…”

Section: Glycogen Turnovermentioning

confidence: 99%

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van den Noort

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Niets wat voor het een of ander als min of meer vaststaand wordt aangenomen hoeft speciaal.Men kan er ook iets anders voor zoeken, iets wat in de buurt zit, maar toch wel afwijkt.Dat hoeft geen imitatie te zijn.Een soort compensatie.Zo zijn in gebruiksvoorwerpen meestal enkele functies prominent boven andere. Maar ook die zijn bruikbaar:een boek onder een te korte tafelpoot, een gebroken lucifer als pion in een zakschaakspel met gaatjes.We doen zo weinig met gebruiksvoorwerpen omdat eventuele secundaire, tertiaire functies visueel zijn beknot door een dwingende vorm, die maar een paar handelingen lijkt te passen. En soms gebeurt het zomaar:de lichtbundel voor de ster -aandacht -werpt een schaduw waarin een toneelmeester zich even koel voelt -rust -Bij Loosdrecht; Monotonen -K. Schippers Contents Introduction Chapter 1. Stability of ligand-induced protein conformation influences affinity in maltose-binding protein Chapter 2. The substrate-binding domains of the osmoregulatory ABC importer OpuA transiently interact Chapter 3. Bacterial resilience: multi-level hierarchical regulation of ABC importer OpuA Chapter 4. Bacterial cell volume regulation and the importance of cyclic di-AMP Chapter 5. We have it all under control

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Section: Cryo-em Image Processing Of Wild-type Opua In 100 MM Kclmentioning

confidence: 99%

Section: Glycogen Turnovermentioning

confidence: 99%

It is all under control

van den Noort

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Bacterial cell volume regulation and the importance of cyclic di-AMP

Foster,

van den Noort,

Poolman

2024

Microbiol Mol Biol Rev

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SUMMARY Nucleotide-derived second messengers are present in all domains of life. In prokaryotes, most of their functionality is associated with general lifestyle and metabolic adaptations, often in response to environmental fluctuations of physical parameters. In the last two decades, cyclic di-AMP has emerged as an important signaling nucleotide in many prokaryotic lineages, including Firmicutes, Actinobacteria, and Cyanobacteria. Its importance is highlighted by the fact that both the lack and overproduction of cyclic di-AMP affect viability of prokaryotes that utilize cyclic di-AMP, and that it generates a strong innate immune response in eukaryotes. In bacteria that produce the second messenger, most molecular targets of cyclic di-AMP are associated with cell volume control. Besides, other evidence links the second messenger to cell wall remodeling, DNA damage repair, sporulation, central metabolism, and the regulation of glycogen turnover. In this review, we take a biochemical, quantitative approach to address the main cellular processes that are directly regulated by cyclic di-AMP and show that these processes are very connected and require regulation of a similar set of proteins to which cyclic di-AMP binds. Altogether, we argue that cyclic di-AMP is a master regulator of cell volume and that other cellular processes can be connected with cyclic di-AMP through this core function. We further highlight important directions in which the cyclic di-AMP field has to develop to gain a full understanding of the cyclic di-AMP signaling network and why some processes are regulated, while others are not.

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The Chemistry of Glycogen

Cited by 2 publications

References 43 publications

It is all under control

It is all under control

Bacterial cell volume regulation and the importance of cyclic di-AMP

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