The chemistry and pharmacology of Cleome genus: A review

Singh, Harpreet; Mishra, Amrita; Mishra, Arun Kumar

doi:10.1016/j.biopha.2018.02.053

Cited by 36 publications

(36 citation statements)

References 48 publications

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“…droserifolia is rich in phytochemicals and several bioactive constituents have been isolated from this species (reviewed in [23,24]). Numerous studies of C. droserifolia have revealed the presence of flavonoids, glycosides, carbohydrates, cardenolides, saponins, sterols, tannins, catechins, triterpenes, and sesquiterpenes, such as buchariol, teucladiol, daucosterol, and a new alkaloid from the aerial parts [22][23][24][25][26][27][28][29][30]. Other than these compounds, it has the distinction of being the first plant source of diterpenoid dolabellane esters as well [31].…”

Section: Introductionmentioning

confidence: 99%

Organic extracts from Cleome droserifolia exhibit effective caspase-dependent anticancer activity

Panicker

Balhamar

Akhlaq

et al. 2020

BMC Complement Med Ther

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Background: This study investigated the anticancer potential of the medicinal herb, Cleome droserifolia (CD), a local plant of the Arabian Peninsula. C. droserifolia is traditionally known for its rubefacient, anti-diabetic, anti-oxidant, and anti-inflammatory properties. Methods: Organic fractions of the aerial parts of Cleome droserifolia harvested from the Arabian Peninsula were tested in human breast and cervical cancer cell lines for their anticancer potential. This was accomplished by using biochemical and cellular assays, including MTT, caspase Glo, western blot, and annexin V/propidium iodide-based flow cytometry analyses. Results: Test of the dichloromethane fraction of the methanolic extract of C. droserifolia, (CDD) revealed potent cytotoxic activity (from 70 to 90%) against several human cancer cell lines, including MCF-7, MDA-MB-231, and HeLa. Further characterization of the CDD fraction in MCF-7 cells revealed that it could activate the enzymatic activity of various caspases in a statistically significant manner, and induce cleavage of both caspase 7 and poly ADB ribose polymerase (PARP) proteins, but not the ethyl acetate fraction. Test of the ability of CDD to induce early signs of apoptosis was validated by annexin V/propidium iodide assay using FACS analysis. Induction of apoptosis was completely reversed by the classic pan inhibitor of apoptosis, Z-VAD-FMK, reducing early apoptosis from 29.7 to 0.6%, confirming that CDD could induce caspase-dependent apoptosis. Conclusions: Altogether, our results reveal that C. droserifolia is a valuable medicinal plant with bioactive molecules that can induce apoptosis in human cancer cells. Thus, this plant should be explored further for its potential as an anticancer natural therapy as well as the isolation of novel molecules with anticancer properties.

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Section: Introductionmentioning

confidence: 99%

Organic extracts from Cleome droserifolia exhibit effective caspase-dependent anticancer activity

Panicker

Balhamar

Akhlaq

et al. 2020

BMC Complement Med Ther

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“…Traditionally a number of ethnic communities in Africa and Asia have reported the spider plant to treat some diseases like, the sap of leaves is used as a pain reliever especially cerebral pain, and Sap from pounded leaves is pressed into ears, nostrils, and eyes to treat fits caused by epilepsy and infections of the ear. A mixture of bubbled roots and leaves is regulated to encourage labor pain in pregnant ladies, treat stomach-throb and constipation, treat conjunctivitis, treat serious thread worm disease, relieve burning chest pains and the leaves are utilized to treat joint inflammation [2,7,8].…”

Section: Mineral and Phytochemical Composition Of Cleome Gynandra Metmentioning

confidence: 99%

“…An infusion of the leaves utilized as an eyewash. Seeds are anthelmintic and rubefacient and are consumed for the removal of roundworms, or a mixture is applied externally on the stomach as a painkiller [2,6,8]. Seeds are blended with oil and applied to the scalp to treat headache, Mixture of seed controls coughing, Seeds are also utilized by veterinarians to treat stomach pains, leaves and the plant have anti-ticks and fleas preventive properties.…”

Section: Mineral and Phytochemical Composition Of Cleome Gynandra Metmentioning

confidence: 99%

“…Seeds are blended with oil and applied to the scalp to treat headache, Mixture of seed controls coughing, Seeds are also utilized by veterinarians to treat stomach pains, leaves and the plant have anti-ticks and fleas preventive properties. A decoction of roots is accounted for to have gentle febrifugal properties and anthelmintic properties [6][7][8][9][10][11][12][13][14][15]. However, the efficacy of the spider plant and long-term safety is not well known.…”

Section: Mineral and Phytochemical Composition Of Cleome Gynandra Metmentioning

confidence: 99%

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Mineral and Phytochemical Composition of Cleome Gynandra Methanolic Extract

2020

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The study was done to evaluate the mineral and phytochemical composition of the methanolic extract of Cleome gynandra (spider plant). The plant is used as a traditional vegetable in some communities in sub-Saharan Africa and Asia. The plant has also been reported to have some medicinal effect due to presence of phytochemicals but its pharmacological and phytochemical profile has not been fully established. Collection and authentication of the plant was done followed by extraction using methanol as a solvent. The phytochemical investigation was done using both chemical analysis and chromatography method by use of a Gas chromatography mass spectroscopy (GCMS) system as per standard protocol. Cleome gynandra was found to contain some mineral compounds of nutritional importance and phytochemicals with potential medicinal importance. The phytochemicals analyzed include saponins, flavonoids, tannins, alkaloids, cardiac glycosides, terpanoids and polyphenols. These different phytochemicals can be further studied and their potential medicinal importance analyzed. The study concluded that Cleome gynandra contains phytochemicals with potentially important medicinal value. The plant (Cleome gynandra) can also be used as an important nutritional source of some essential nutrients like Vitamin C and beta carotene. It can also be a good source of some mineral elements like iron, selenium, cobalt, copper, zinc and manganese. This can be important for families in rural areas and for the low-income households in both rural and urban areas as a source of nutrients.

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“…The germinating, flowering and fruiting stage of this plant are in May, September and October, respectively (Ghaderian and Baker 2007). Various biological activities have been known for different species of Cleome (Singh et al 2018), such as anti-microbial and insecticidal activities (Williams et al 2003), anti-inflammatory (Puchchakayala et al 2008), antioxidant (Narendhirakannan et al 2007), hepatoprotective (Gupta and Dixit 2009). The aim of this research is focused on comprehensive assessment of phytochemical and fatty acid composition as well as antioxidant activity of different extracts from roots and aerial parts in different phenological periods of C. heratensis.…”

mentioning

confidence: 99%

Phytochemical and antioxidant studies of Cleome heratensis (Capparaceae) plant extracts

Nasseri

Behravesh

Allahresani

et al. 2019

Bioresour. Bioprocess.

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Background: In this research, different active phytochemical constituents present in Cleome heratensis (C. heratensis) from Capparaceae family were investigated. Moreover, the fatty acids present in the seed and aerial parts of the plant were identified by gas chromatography (GC) after esterification of the oil. Antioxidant activity of the aerial parts and seed of C. heratensis methanolic extract over 2,2′-diphenylpicryl-1-hydrazyl (DPPH) was investigated using ultravioletvisible (UV-Vis) spectrophotometer. Methods: To study total phenolic compounds and flavonoids, the plant was extracted from ethanol by ultrasonic method, then further extracted with other solvents. Amounts of anthocyanins and tannins/condensed tannins were determined by their corresponding ethanolic and acetone extracts. Antioxidant activity of the plant species was studied by a spectrophotometric method using 80% methanolic extract. Results: The high content of phenolics as 16.915 mg tannic acid equivalents per gram of dry matter (TAE/g DM), tannins (12.231 mg TA/gr DM) and condensed tannins (4.086 mg TA/g DM) was obtained for the C. heratensis extract. The most flavonoids content was found 4.444 rutin equivalents (in mg) per gram of dry matter (mg RE/g DM) in plant's aerial extract. The most amount of anthocyanin (0.48 mmol/gr WM) was observed in flowering stage. Antioxidant activity of the aerial parts and seed of C. heratensis methanolic extract were 11.92 and 63.54 mg/mL IC 50 , respectively. Conclusion: High level of phenolic components including flavonoids, proanthocyanidins and tannins was detected in the extract of aerial parts of the plant. The oil of seed of this plant is a rich source of saturated and unsaturated fatty acids. Finally, C. heratensis aerial part extract was found as an excellent natural antioxidant.

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The chemistry and pharmacology of Cleome genus: A review

Cited by 36 publications

References 48 publications

Organic extracts from Cleome droserifolia exhibit effective caspase-dependent anticancer activity

Organic extracts from Cleome droserifolia exhibit effective caspase-dependent anticancer activity

Mineral and Phytochemical Composition of Cleome Gynandra Methanolic Extract

Phytochemical and antioxidant studies of Cleome heratensis (Capparaceae) plant extracts

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