The chemistry and engineering of mussel-inspired glue matrix for tissue adhesive and hemostatic

Phuong, Pham Thi My; Won, Hyun Jeong; Oh, Yeon Jeong; Lee, Hyoung Sin; Lee, Kang Dae; In, Insik

doi:10.1016/j.jiec.2019.06.005

Cited by 34 publications

(15 citation statements)

References 48 publications

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“…For example, graphitic carbon nitrides (g-C 3 N 4 ) have been presented in the field of photocatalytic water splitting for hydrogen production [ 46 , 47 ]. Carbon dots (CDs) with a diameter of <10 nm possess unique electron-transfer abilities and a large specific surface area, rendering them excellent catalysts as well as potential candidates for versatile applications [ 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ]. The presence of several functional groups (-OH, -COOH, -NH 2 , etc.)…”

Section: Introductionmentioning

confidence: 99%

Construction of FeCo2O4@N-Doped Carbon Dots Nanoflowers as Binder Free Electrode for Reduction and Oxidation of Water

et al. 2020

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Electrochemical water splitting is known as a potential approach for sustainable energy conversion; it produces H2 fuel by utilizing transition metal-based catalysts. We report a facile synthesis of FeCo2O4@carbon dots (CDs) nanoflowers supported on nickel foam through a hydrothermal technique in the absence of organic solvents and an inert environment. The synthesized material with a judicious choice of CDs shows superior performance in hydrogen and oxygen evolution reactions (HER and OER) compared to the FeCo2O4 electrode alone in alkaline media. For HER, the overpotential of 205 mV was able to produce current densities of up to 10 mA cm−2, whereas an overpotential of 393 mV was needed to obtain a current density of up to 50 mA cm−2 for OER. The synergistic effect between CDs and FeCo2O4 accounts for the excellent electrocatalytic activity, since CDs offer exposed active sites and subsequently promote the electrochemical reaction by enhancing the electron transfer processes. Hence, this procedure offers an effective approach for constructing metal oxide-integrated CDs as a catalytic support system to improve the performance of electrochemical water splitting.

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Section: Introductionmentioning

confidence: 99%

Construction of FeCo2O4@N-Doped Carbon Dots Nanoflowers as Binder Free Electrode for Reduction and Oxidation of Water

et al. 2020

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“…The MTT solution was added after the removal of the stock solution. The cell viability was evaluated by using a microplate reader with an absorbance wavelength of 570 nm [35].…”

Section: Methodsmentioning

confidence: 99%

Reduction-Triggered Paclitaxel Release Nano-Hybrid System Based on Core-Crosslinked Polymer Dots with a pH-Responsive Shell-Cleavable Colorimetric Biosensor

Kim

Ryplida

Phuong

et al. 2019

IJMS

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Herein, we describe the fabrication and characterization of carbonized disulfide core-crosslinked polymer dots with pH-cleavable colorimetric nanosensors, based on diol dye-conjugated fluorescent polymer dots (L-PD), for reduction-triggered paclitaxel (PTX) release during fluorescence imaging-guided chemotherapy of tumors. L-PD were loaded with PTX (PTX loaded L-PD), via π–π stackings or hydrophobic interactions, for selective theragnosis by enhanced release of PTX after the cleavage of disulfide bonds by high concentration of glutathione (GSH) in a tumor. The nano-hybrid system showed fluorescence quenching behavior with less than 2% of PTX released under physiological conditions. However, in a tumor microenvironment, the fluorescence recovered at an acidic-pH, and PTX (approximately 100% of the drug release) was released efficiently out of the matrix by reduction caused by the GSH level in the tumor cells, which improved the effectiveness of the cancer treatment. Therefore, the colorimetric nanosensor showed promising potential in distinguishing between normal and cancerous tissues depending on the surrounding pH and GSH concentrations so that PTX can be selectively delivered into cancer cells for improved cancer diagnosis and chemotherapy.

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“…The medium was then removed and MTT solubilizing agents (200 μL) were added. After a 15 min shake, the absorbances were determined by a microplate reader (Filter Max F3, Molecular Device) at 570 nm …”

Section: Experimental Sectionmentioning

confidence: 99%

NIR-vis-Induced pH-Sensitive TiO₂ Immobilized Carbon Dot for Controllable Membrane-Nuclei Targeting and Photothermal Therapy of Cancer Cells

Phuong

Won

Robby

et al. 2020

ACS Appl. Mater. Interfaces

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This study investigated a selective and sensitive theragnosis system for the specific targeting of the membrane and nuclei based on visible-light and pH-responsive TiO2-integrated cross-linked carbon dot (C-CD/TiO2) for tumor detection and controllable photothermal therapy. The cross-linking system was formed by boronate ester linkages between the TiO2-immobilized Dopa-decyl (D-CD) and zwitterionic-formed CD (Z-CD) for nuclear targeting, which showed fluorescence “off” at physiological pH. The fluorescence recovered to the “on” state in acidic cancer cells owing to cleavages of the boronate ester bonds, resulting in the disruption of the Förster resonance energy transfer that generated different CDs useful for tumor-selective biosensors and therapy. D-CD, which is hydrophobic, can penetrate the hydrophobic sites of the cell membrane; it caused a loss in the hydrophobicity of these sites after visible-light irradiation. This was achieved by the photocatalytic activity of the TiO2 modulating energy bandgap, whereas the Z-CD targeted the nucleus, as confirmed by merged confocal microscopy images. D-CD augmented by photothermal heat also exhibited selective anticancer activity in the acidic tumor condition but showed only minimal effects at a normal site at pH 7.4. After C-CD/TiO2 injection to an in vivo tumor model, C-CD/TiO2 efficiently ablated tumors under NIR light irradiation. The C-CD/TiO2 group showed up-regulation of the pro-apoptotic markers such as P53 and BAX in tumor. This material exhibited its potential as a theragnostic sensor with excellent biocompatibility, high sensitivity, selective imaging, and direct anticancer activity via photothermal therapy.

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The chemistry and engineering of mussel-inspired glue matrix for tissue adhesive and hemostatic

Cited by 34 publications

References 48 publications

Construction of FeCo2O4@N-Doped Carbon Dots Nanoflowers as Binder Free Electrode for Reduction and Oxidation of Water

Construction of FeCo2O4@N-Doped Carbon Dots Nanoflowers as Binder Free Electrode for Reduction and Oxidation of Water

Reduction-Triggered Paclitaxel Release Nano-Hybrid System Based on Core-Crosslinked Polymer Dots with a pH-Responsive Shell-Cleavable Colorimetric Biosensor

NIR-vis-Induced pH-Sensitive TiO₂ Immobilized Carbon Dot for Controllable Membrane-Nuclei Targeting and Photothermal Therapy of Cancer Cells

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The chemistry and engineering of mussel-inspired glue matrix for tissue adhesive and hemostatic

Cited by 34 publications

References 48 publications

Construction of FeCo2O4@N-Doped Carbon Dots Nanoflowers as Binder Free Electrode for Reduction and Oxidation of Water

Construction of FeCo2O4@N-Doped Carbon Dots Nanoflowers as Binder Free Electrode for Reduction and Oxidation of Water

Reduction-Triggered Paclitaxel Release Nano-Hybrid System Based on Core-Crosslinked Polymer Dots with a pH-Responsive Shell-Cleavable Colorimetric Biosensor

NIR-vis-Induced pH-Sensitive TiO2 Immobilized Carbon Dot for Controllable Membrane-Nuclei Targeting and Photothermal Therapy of Cancer Cells

Contact Info

Product

Resources

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NIR-vis-Induced pH-Sensitive TiO₂ Immobilized Carbon Dot for Controllable Membrane-Nuclei Targeting and Photothermal Therapy of Cancer Cells