The chemical process of oxidative stress by copper(II) and iron(III) ions in several neurodegenerative disorders

Nishida, Yuzo

doi:10.1007/s00706-010-0444-8

Cited by 47 publications

(34 citation statements)

References 71 publications

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“…It is the result of an imbalance between the production of reactive oxygen species (ROS) and antioxidant defences in living organisms (Nishida, 2011). Reactive oxygen species are induced by substances such as transitional metal ions, pesticides, and petroleum pollutants (Slaninova et al, 2009;Lushchak, 2011).…”

Section: Oxidative Stress and Antioxidant Defencesmentioning

confidence: 99%

Metals as a cause of oxidative stress in fish: a review

Ševčíková¹,

Modrá²,

Slaninova³

et al. 2011

Vet. Med.

312

123

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ABSTRACT:This review summarizes the current knowledge on the contribution of metals to the development of oxidative stress in fish. Metals are important inducers of oxidative stress in aquatic organisms, promoting formation of reactive oxygen species through two mechanisms. Redox active metals generate reactive oxygen species through redox cycling, while metals without redox potential impair antioxidant defences, especially that of thiol-containing antioxidants and enzymes. Elevated levels of reactive oxygen species lead to oxidative damage including lipid peroxidation, protein and DNA oxidation, and enzyme inactivation. Antioxidant defences include the enzyme system and low molecular weight antioxidants. Metal-binding proteins, such as ferritin, ceruloplasmin and metallothioneins, have special functions in the detoxification of toxic metals and also play a role in the metabolism and homeostasis of essential metals. Recent studies of metallothioneins as biomarkers indicate that quantitative analysis of mRNA expression of metallothionein genes can be appropriate in cases with elevated levels of metals and no evidence of oxidative damage in fish tissue. Components of the antioxidant defence are used as biochemical markers of oxidative stress. These markers may be manifested differently in the field than in results found in laboratory studies. A complex approach should be taken in field studies of metal contamination of the aquatic environment. Keywords: ROS; metallothioneins; glutathion; superoxide dismutase; antioxidant defenceList of abbreviations ALA-D = aminolevulinic acid dehydratase; BNF = β-naphthoflavone; CAT = catalase; GPx = glutathione peroxidise; GR = glutathione reductase; GSH = glutathione; GSSG = glutathione disulphide; GST = glutathione S-transferase; LPO = lipid peroxidation; MDA = malondialdehyde; MTs = metallothioneins; NADPH = nicotinamidadeninedinucleotide phosphate (reduced); ROS = reactive oxygen species; SOD = superoxide dismutase

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Section: Oxidative Stress and Antioxidant Defencesmentioning

confidence: 99%

Metals as a cause of oxidative stress in fish: a review

Ševčíková¹,

Modrá²,

Slaninova³

et al. 2011

Vet. Med.

312

123

View full text Add to dashboard Cite

show abstract

“…Oxidative stress, an unavoidable aspect of aerobic life, is the result of an imbalance between pro-oxidants and antioxidants (Nishida 2011). Pro-oxidants are chemical complexes that induce oxidative stress through the production of free radicals, including reactive oxygen species (ROS), or through inhibition of antioxidant systems.…”

mentioning

confidence: 99%

Assessment of oxidative stress in Flathead mullet (Mugil cephalus) and Gilthead sea bream (Sparus aurata)

Fazio¹,

Piccione²,

Saoca³

et al. 2015

Vet. Med. - Czech

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ABSTRACT:In this work we compared two species of fish with different feeding habits: Flathead mullet (Mugil cephalus) and Gilthead sea bream (Sparus aurata). The aim of this study was to evaluate total oxidant status (TOS), total antioxidant capacity (TAC) and TOS/TAC ratio (OSI), in order to highlight the presence of any differences and correlations in these two different species of fish. Thirty adult fish of Mugil cephalus and thirty of Sparus aurata were used. From each fish 0.6 ml of blood was collected. TOS and TAC indicators were measured in serum obtained from samples previously clotted and centrifuged. Our results showed statistically significant differences between the two species in TAC. TOS and OSI did not show significant differences between Gilthead sea bream and Flathead mullet. A positive relationship between TOS and TAC was found in Flathead mullet (Mugil cephalus), and a negative relation between TOS and TAC in Gilthead sea bream (Sparus aurata). Our study indicates that the oxidative status and the relationship between total oxidant status (TOS) and total antioxidant capacity (TAC) in serum are probably dependent on the fish species and are affected by different feeding habits.Keywords: total oxidant status; total antioxidant capacity; teleost species; redox balance List of abbreviations FRAP = ferric reducing antioxidant potential, ROM = reactive oxygen metabolites, ROS = reactive oxygen species, TAC = total antioxidant capacity, TOS = total oxidant status, OSI = oxidative stress index (TOS/TAC ratio)

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“…This should be due to the strong electrophilicity of the (-peroxo)(-oxo)-diiron(III) species (species (A) in Scheme I) formed in the solution (Nishida, 2003(Nishida, , 2004(Nishida, , 2011(Nishida, , 2012a(Nishida, , 2012b, which turns to the di--oxo-diiron(III) species by oxidizing the methanol in the solution The further aggregation of the di--oxo-diiron(III) species may proceed to give the iron deposition (see (C) in Scheme I), because it has been pointed out that the iron deposition is the aggregation of di--oxo-diiron (III) species based on the structural properties of hydroxo(oxo)iron clusters (Nishida, 2012a(Nishida, , 2012c; this is exemplified by the recent our work (Abe, Sakiyama & Nishida, 2015a). As these polymeric iron(III) ions are not transferred to apo-transferrin (Nishida, Ito & Satoh, 2007;Nishida, 2012c), above discussion explains the marked iron accumulation in the brain as well as visceral tissue despite low serum iron levels, and under these conditions where excess hydrogen peroxide is present.…”

Section: Hydrogen Peroxide and Ntbimentioning

confidence: 99%

“…Recently the origin of the iron toxicity to induce oxidative stress has been elucidated by us on the chemical point of view (Nishida, 2003(Nishida, , 2004(Nishida, , 2011(Nishida, , 2012a(Nishida, , 2012b; in our mechanism the contribution of hydroxyl radical is completely denied, which has been supported by the recent work by Enami et al (Enami, Sakamoto & Colussi, 2014); the formation of the Fe(IV)=O species observed by Enami et al can be reasonably explained in terms of concerted mechanism proposed by Nishida (Nishida, 2012b). In addition to this, we have succeeded in elucidating the mechanism of accumulation of iron ion and formation of iron deposition in the brain of patients with neurodegenerative disorders (Nishida, 2012c, Abe, Sakiyama & Nishida, 2015a.…”

Section: Introductionmentioning

confidence: 99%

Abnormal Iron Accumulation in Brain and New Iron Chelator for Labile Iron Removal Therapy

Nishida¹

2015

IJC

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The homeostasis of transition metal ions is central to many life processes, but the alterations in Fe, Zn, and Mn homeostasis are observed in the brain of patients of several neurodegenerative disorders. Abnormally high levels of non-transferrin-bound iron ions (NTBI), or labile iron ion, have been demonstrated in a number of neurodegenerative disorders including dementia, Parkinson's disease (PD) and Alzheimer's disease (AD), and oxidative stress closely related with NTBI in the brain is widely believed to be associated with neuronal death in these diseases. We have investigated the chemical mechanism of the abnormal accumulation of iron ions in the brain observed for the patients of neurodegenerative disorders, and based on these results we have prepared the new iron chelators, so-called super-polyphenols. Since our super-polyphenols can excrete only NTBI effectively from the plasma, not the iron in the holo-transferrin, our super polyphenols should be one of the most hopeful substances for labile iron removal therapy, including the prevention of dementia, Alzheimer's and Parkinson's diseases. Our super-polyphenols are characterized by the following four points, i.e., 1) these super-polyphenols are water-insoluble, 2) these are not metabolized in the human body due to its insolubility in water and its polymeric structure (MW~90,000), 3) their iron (III) chelates are also water-insoluble, and 4) they do not interact with the iron ions in the holo-transferrin, and because of the these properties our super-polyphenols give no damage to human body.

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The chemical process of oxidative stress by copper(II) and iron(III) ions in several neurodegenerative disorders

Cited by 47 publications

References 71 publications

Metals as a cause of oxidative stress in fish: a review

Metals as a cause of oxidative stress in fish: a review

Assessment of oxidative stress in Flathead mullet (Mugil cephalus) and Gilthead sea bream (Sparus aurata)

Abnormal Iron Accumulation in Brain and New Iron Chelator for Labile Iron Removal Therapy

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