The chemical and physical stability of three intravenous infusions subjected to frozen storage and microwave thawing

Microwave freeze-thaw technique of injectable drugs. A review from 1980 to 2014

“…It is the case, 29 drugs described in 20 papers [15,24,[27][28][29][30]32,33,[42][43][44][45]47,52,[55][56][57]59,61,63,76]. The stability for a period of 24 hours at least was described for 17 drugs in 8 papers [22,[26][27][28][29]34,41,43,48].…”

“…Imipenem was not tested but meet probably the same characteristics. For macrolides (J01FA), erythromycin support MFTT [43]. Clindamycine (lincosamide, J01FF) also [27].…”

“…It is also the case for beta-lactamase resistant penicillins, (cloxacillin [43], flucloxacillin [48], nafcillin [27] oxacillin [26]). The stability for storage after thawing was evaluated [26,27,43,48]. Combinations of penicillins and beta-lactamases (J01CR: piperacilline + tazobactam) was submitted with success to MFTT and can be stored after thawing [62].…”

“…For beta-lactamase sensitive penicillins, (J01CE), penicillin G support MFTT and stability for storage after thawing was evaluated [26]. It is also the case for beta-lactamase resistant penicillins, (cloxacillin [43], flucloxacillin [48], nafcillin [27] oxacillin [26]). The stability for storage after thawing was evaluated [26,27,43,48].…”

Stability-indicating RP-LC method for quantification of fusidic acid in cream

“…In the literature there are some articles that describe this method for the quantification of FA in biological fluids (Hikal, 1983;Nawaz et al, 2014;Rahman, Hoffman, 1988;Sewell, Palmer, 1991;Sorense, 1988) and in pharmaceutical products (Ankam et al, 2010;British Pharmacopeia, 2010;Byrne, Velasco-Torrijos, Reinhardt, 2014Goswami, Gupta, Jogia, 2013;Hikal, Shibl, El-Hoofy, 1982;Hong, Rong, 2012;Peh, Tan, 2000;Nawaz et al, 2014;Nianfen, Yandong, Mooling, 2009;Shaikh et al, 2009). However, some of these methods are time consuming, have complex mobile phases, or require buffer solution, while others require long running times, high injection volumes and flow rates, or high FA concentrations in the sample.…”