The chemical and metabolite profiles of Gualou-Xiebai-Banxia decoction, a classical traditional Chinese medicine formula, by using high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry and in-house software

Strategy of combining offline 2D LC‐MS with LC‐DIA‐MS/MS to accurately identify chemical compounds and for quality control of Dioscorea septemloba Thunb

“…In recent years, due to the advantages of rapid analysis, high sensitivity, and excellent accuracy, LC‐MS has been used in various fields of TCMs 30–33 . In order to clarify the pharmacodynamic material basis of TCMs and ensure the safety of clinical usage, it is necessary to conduct comprehensive and systematic characterization and quality control of chemical components of TCMs.…”

“…In recent years, due to the advantages of rapid analysis, high sensitivity, and excellent accuracy, LC-MS has been used in various fields of TCMs. [30][31][32][33] In order to clarify the pharmacodynamic material basis of Compared with the literature that has been reported so far, our proposed method could detect more chemical components in DST by increasing the capacity and improving the orthogonality, thus laying a foundation for the qualitative analysis of DST. The number of compounds identified was also much higher than that identified by conventional UHPLC-MS/MS.…”

Enhanced Identification of Ginsenosides Simultaneously from Seven Panax Herbal Extracts by Data-Dependent Acquisition Including a Preferred Precursor Ions List Derived from an In-House Programmed Virtual Library

“…It is crucial to establish precise and fit-for-purpose analytical techniques that can implement the characterization and quantification of metabolites for a number of research areas (e.g., natural product research and food science). , At the same time, it is still confronted with challenges for the detection and analysis of the metabolites owing to the severe endogenous interference and, in most cases, the low content in a complex matrix. In recent years, liquid chromatography/mass spectrometry (LC/MS) has provided a powerful and practical method enabling the systematic characterization of known compounds, as well as the discovery of potentially new components from natural products. − Nowadays, the utilization of multidimensional chromatography (MDC) greatly improves the selectivity and expands the peak capacity, , while various MS strategies are available to maximize the qualitative MS information supporting the identification of metabolites. , The utilization of various scan methods has been demonstrated as potent in the in-depth characterization and multicomponent quantitation of various metabolites from herbal extracts. , …”

“…It is crucial to establish precise and fit-for-purpose analytical techniques that can implement the characterization and quantification of metabolites for a number of research areas (e.g., natural product research and food science). 1,2 At the same time, it is still confronted with challenges for the detection and analysis of the metabolites owing to the severe endogenous interference and, in most cases, the low content in a complex matrix. In recent years, liquid chromatography/mass spectrometry (LC/MS) has provided a powerful and practical method enabling the systematic characterization of known compounds, as well as the discovery of potentially new components from natural products.…”

Correlation between the redox activity of Polygonum multiflorum extract and its extraction technology with Chinese liquor (Baijiu): An electrochemistry-based study

“…Finding a suitable solvent that can dissolve these active ingredients is essential for improving the extracting efficacy of TCM [ 11 ]. Thus, the typical Chinese distilled liquor (also called Chinese Baijiu ), a readily available organic solvent in ancient times, naturally became the best solvent for extracting the active ingredients of TCM [ 12 ]. In China, soaking TCM in liquor has a long history [ 13 ]; liquor was employed to soak TCM as early as the Spring and Autumn Warring States Period [ 14 ].…”