The Characteristics of Deep Optic Nerve Head Morphology in Myopic Normal Tension Glaucoma

Han, Jong Chul; Lee, Eun Jung; Kim, Si Bum; Kee, Changwon

doi:10.1167/iovs.17-21791

Cited by 26 publications

(51 citation statements)

References 30 publications

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“…In this respect, the current observations that focal γPPA group had thinner RNFL than no γPPA group in the TI sector, an area in which focal LC defect and maximal focal γPPA frequently develop add to the literature. 14 Because focal LC defects are known to be closely associated with functional and structural damage to RGC axons, 11,26,27 development of an EOBT, glaucomatous RNFL defect, and focal LC defect may share a common pathway. Similarly, eyes with a focal LC defect had significantly thinner RNFL in the TI sector in all three subgroups of γPPA.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Focal Gamma Zone Parapapillary Atrophy

Kim

Weinreb

Zangwill

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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Citation: Kim HR, Weinreb RN, Zangwill LM, Suh MH. Characteristics of focal gamma zone parapapillary atrophy. Invest Ophthalmol Vis Sci. 2020;61(3):17. https://doi.org/10.1167/iovs.61.3.17 PURPOSE.The purpose of this study was to investigate the characteristics of focal γ-zone parapapillary atrophy (focal γPPA) in patients with primary open-angle glaucoma (POAG) using spectral-domain optical coherence tomography (SD-OCT). METHODS.Three groups of POAG eyes (n = 214) were defined according to the circumferential extent of Bruch's membrane (BM) within the β-zone PPA, as follows: (1) no γPPA (intact BM; n = 81), (2) conventional γPPA (γPPA involving the fovea-BM-opening axis; n = 89), and (3) focal γPPA (γPPA not involving the fovea-BM-opening axis; n = 44). Clinical and ocular characteristics, including age, axial length (AXL), and focal lamina cribrosa (LC) defects were compared among the three groups. RESULTS.The focal γPPA group was significantly older (60.6 ± 11.0 years) and had shorter AXL (24.10 ± 1.34 mm) than those of the conventional γPPA group (46.2 ± 13.8 years and 26.53 ± 1.61 mm, respectively; P < 0.001). These values of the focal γPPA group were similar to those of the no γPPA group (23.73 ± 0.97 mm for AXL and 64.0 ± 13.0 years for age). The focal γPPA group had a significantly higher prevalence of focal LC defects than did the other two groups (70.5% [31/44] for the focal γPPA group versus 46.1% [41/89] for the conventional γPPA group versus 37.0% [30/81] for the no γPPA group; P = 0.002). CONCLUSIONS.Focal γPPA was differentiated from conventional γPPA by older age and shorter AXL. Further, focal γPPA was frequently accompanied by focal LC defects. Longitudinal studies elucidating whether focal LC defects and focal γPPA share common pathogenesis are warranted.

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Section: Discussionmentioning

confidence: 99%

Characteristics of Focal Gamma Zone Parapapillary Atrophy

Kim

Weinreb

Zangwill

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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“…The border tissue is a cuff of collagenous tissue arising from the sclera that joins the Bruch’s membrane at the optic disc margin 75. Han et al 78 evaluated the externally oblique border tissue length, optic nerve head tilt angle and optic canal obliqueness, and observed that temporally located maximal values for these parameters were independently associated with the presence of myopic normal-tension glaucoma, and were consistent with the location of retinal nerve fibre layer defects.…”

Section: Introductionmentioning

confidence: 99%

Imaging in myopia: potential biomarkers, current challenges and future developments

et al. 2019

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Myopia is rapidly increasing in Asia and around the world, while it is recognised that complications from high myopia may cause significant visual impairment. Thus, imaging the myopic eye is important for the diagnosis of sight-threatening complications, monitoring of disease progression and evaluation of treatments. For example, recent advances in high-resolution imaging using optical coherence tomography may delineate early myopic macula pathology, optical coherence tomography angiography may aid early choroidal neovascularisation detection, while multimodal imaging is important for monitoring treatment response. However, imaging the eye with high myopia accurately has its challenges and limitations, which are important for clinicians to understand in order to choose the best imaging modality and interpret the images accurately. In this review, we present the current imaging modalities available from the anterior to posterior segment of the myopic eye, including the optic nerve. We summarise the clinical indications, image interpretation and future developments that may overcome current technological limitations. We also discuss potential biomarkers for myopic progression or development of complications, including basement membrane defects, and choroidal atrophy or choroidal thickness measurements. Finally, we present future developments in the field of myopia imaging, such as photoacoustic imaging and corneal or scleral biomechanics, which may lead to innovative treatment modalities for myopia.

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“…In our recent study, we defined the deep ONH-associated parameters, such as externally oblique border tissue (EOBT) length, ONH tilt angle and optic canal (OC) obliqueness using BMO and border tissue, and reported that the maximum values of the deep ONH parameters were associated with axial length (AL). 13 In myopic normal tension glaucoma (NTG) eyes, the locations of the parameters showed topographic correspondence with RNFL defect. 13 Furthermore, the deep ONH parameters could demonstrate deep ONH vertical asymmetry even in ONH without definite PPA or disc tilt.…”

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confidence: 99%

Deep Optic Nerve Head Morphology Is Associated With Pattern of Glaucomatous Visual Field Defect in Open-Angle Glaucoma

Han

Choi

Park

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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The Characteristics of Deep Optic Nerve Head Morphology in Myopic Normal Tension Glaucoma

Abstract: Temporalized angular locations of deep ONH parameters were associated with the presence of NTG in myopia. In myopic NTGs, the locations of deep ONH parameters were consistent with the locations of RNFL defect.

Cited by 26 publications

References 30 publications

Characteristics of Focal Gamma Zone Parapapillary Atrophy

Characteristics of Focal Gamma Zone Parapapillary Atrophy

Imaging in myopia: potential biomarkers, current challenges and future developments

Deep Optic Nerve Head Morphology Is Associated With Pattern of Glaucomatous Visual Field Defect in Open-Angle Glaucoma

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