Deep Optic Nerve Head Morphology Is Associated With Pattern of Glaucomatous Visual Field Defect in Open-Angle Glaucoma

Han, Jong Chul; Choi, Jae Hwan; Park, Do Young; Lee, Eun Jung; Kee, Changwon

doi:10.1167/iovs.18-24588

Cited by 7 publications

(15 citation statements)

References 30 publications

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“…In other words, macular GCIPL thinning can be accompanied by ONH deformation with temporal elongation of EOBT. In fact, even in non-myopia eyes, EOBT is frequently detected, and a prior study suggested that the direction of EOBT elongation, rather than the length of EOBT itself, aligns with the location of glaucomatous changes in ONH, increasing the susceptibility of glaucomatous damage 9 . Another study reported that gamma zone PPA in non-myopic eyes was associated with tilted discs, which may induce asymmetric strain on nerve fibers 19 , 20 .…”

Section: Discussionmentioning

confidence: 99%

“…Deep ONH structural characteristics are considered to be related to the vulnerability of glaucomatous optic nerve damage 7 , 8 . As a marker of deformation in deep ONH structure, the location where the externally oblique border tissue (EOBT) is elongated the most was reported to coincide with the location of glaucomatous optic disc damage 8 , 9 . It is also co-localized with the site of LC defect or choroidal microvascular dropout 10 , suggesting that the area exposed to maximum stress in the ONH may be more susceptible to various insults that induce glaucoma.…”

Section: Introductionmentioning

confidence: 99%

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Border tissue morphology is associated with macular ganglion cell thickness in open-angle glaucoma

Park

Jang

Kim

et al. 2022

Sci Rep

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Externally oblique border tissue (EOBT) configuration is topographically associated with glaucomatous damage in the optic nerve head. We investigated the relationship between the EOBT characteristics and macular retinal ganglion cell (RGC) thickness in patients with open-angle glaucoma (OAG). A total of 149 eyes with OAG that had an EOBT observed on optical coherence tomography exams were included. After determining the maximum EOBT length and angular location of the maximal EOBT length, we analyzed their correlation with macular ganglion cell inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) thickness. The macular GCIPL and pRNFL thickness were compared based on the angular location of the longest EOBT, and their association was assessed using multivariable regression analysis. Maximum EOBT length was significantly correlated with macular GCIPL thickness, but not with pRNFL thickness. Macular GCIPL was thinnest in eyes with EOBT located in a temporal direction to the optic disc. Longer maximum EOBT and temporally elongated EOBT were independently associated with a thinner macular GCIPL in the multivariable regression analysis. These suggest that temporal elongation of the EOBT may increase the stress and strain on the RGCs derived from the macula and make RGCs more susceptible to glaucoma-inducing damage.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Border tissue morphology is associated with macular ganglion cell thickness in open-angle glaucoma

Park

Jang

Kim

et al. 2022

Sci Rep

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“…Otherwise, the location of each parameter was assigned a negative value. A schematic diagram of these parameters is provided in the authors’ previous work [ 6 , 7 ] ( Figure 1 ).…”

Section: Methodsmentioning

confidence: 99%

“…Although intraocular pressure (IOP) plays the most important role in glaucomatous ONH injury, the location of optic disc damage cannot be predicted by IOP. On the other hand, the deep ONH structures and their locational properties are deeply associated with the site of the glaucomatous ONH damage [ 4 , 5 , 6 , 7 ]. Visualization of deep ONH structures such as Bruch’s membrane (BM) openings or border tissue of Elschnig using optical coherence tomography (OCT) has made it possible to evaluate the association between deep ONH structures and glaucomatous damage by objectively measuring the ONH parameters [ 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…In our prior studies, we measured deep ONH parameters including externally oblique border tissue (EOBT) length, ONH tilt angle, and optic canal (OC) obliqueness and found that these characteristics were associated with the presence of glaucoma and the location of glaucomatous damage in eyes with myopic normal tension glaucoma [ 6 , 7 ]. In addition to these parameters, anterior lamina cribrosa insertion depth (ALID) has recently been demonstrated to represent the posterior migration of the laminar insertion and is displaced more posteriorly in eyes with POAG than in healthy eyes [ 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Topographic Relationships among Deep Optic Nerve Head Parameters in Patients with Primary Open-Angle Glaucoma

Park

Noh

Kee

et al. 2022

JCM

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Purpose: To investigate the topographic relationships among the deep optic nerve head (ONH) parameters representing myopic axial elongation or changes in the lamina cribrosa (LC) in patients with primary open-angle glaucoma (POAG). Methods: Among patients with POAG who visited the clinic between January 2015 and March 2017, the following deep ONH parameters were measured using spectral-domain optical coherence tomography (SD-OCT): externally oblique border tissue (EOBT) length, ONH tilt angle, optic canal (OC) obliqueness, and anterior LC insertion depth (ALID). In addition, the angular locations of the maximal value of each parameter were measured. We analyzed the correlations between the parameters, correlations with axial length (AL), and the spatial correspondence with glaucomatous ONH damage. Results: A total of 100 eyes with POAG were included in the analysis. The EOBT length, ONH tilt angle, and OC obliqueness were correlated with each other and with AL, whereas ALID showed less correlation with the other parameters and AL. The angular location where the three AL-related parameters had maximum values was also correlated with the predominant region of the glaucomatous ONH damage, while the angular location of the deepest ALID showed less correlation. Conclusion: Among the deep ONH parameters, the AL-related parameters EOBT length, ONH tilt angle, and OC obliqueness showed strong spatial correspondence with glaucomatous ONH damage, whereas the LC-related parameter ALID was less correlated with both AL and the region with glaucomatous ONH damage. Further studies are needed to determine how these differences affect glaucomatous ONH change.

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Border Tissue Morphology Is Spatially Associated with Focal Lamina Cribrosa Defect and Deep-Layer Microvasculature Dropout in Open-Angle Glaucoma

Han

Choi

Park

et al. 2019

American Journal of Ophthalmology

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Deep Optic Nerve Head Morphology Is Associated With Pattern of Glaucomatous Visual Field Defect in Open-Angle Glaucoma

Abstract: The locations of maximum deep ONH parameters were associated with the location of dominant VF defects and presence of paracentral scotoma in OAG eyes.

Cited by 7 publications

References 30 publications

Border tissue morphology is associated with macular ganglion cell thickness in open-angle glaucoma

Border tissue morphology is associated with macular ganglion cell thickness in open-angle glaucoma

Topographic Relationships among Deep Optic Nerve Head Parameters in Patients with Primary Open-Angle Glaucoma

Border Tissue Morphology Is Spatially Associated with Focal Lamina Cribrosa Defect and Deep-Layer Microvasculature Dropout in Open-Angle Glaucoma

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