Border Tissue Morphology Is Spatially Associated with Focal Lamina Cribrosa Defect and Deep-Layer Microvasculature Dropout in Open-Angle Glaucoma

Han, Jong Chul; Choi, Jae Hwan; Park, Do Young; Lee, Eun Jung; Kee, Changwon

doi:10.1016/j.ajo.2019.02.023

Cited by 20 publications

(30 citation statements)

References 31 publications

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“…[26] This study also found that MvD was not, but focal LC defects were, detected the normal control group. [26] Another study investigated the topographic correlation between juxtapapillary PCT and MvD. [30] Localized thinning of the mean juxtapapillary PCT value was observed at the location of MvD in the primary open-angle glaucoma eyes with a parapapillary γ-zone.…”

Section: Plos Onesupporting

confidence: 57%

“…[24][25][26][27][28][29] These studies found that the location of MvD is topographically associated with focal LC defect locations and that both focal LC defects and MvD are associated with peripapillary atrophy in glaucomatous eyes. [24][25][26][27][28][29] The findings of one study also suggested that compared with focal LC defects, the presence of MvD is more strongly associated with glaucoma severity. [26] This study also found that MvD was not, but focal LC defects were, detected the normal control group.…”

Section: Plos Onementioning

confidence: 91%

“…[24][25][26][27][28][29] The findings of one study also suggested that compared with focal LC defects, the presence of MvD is more strongly associated with glaucoma severity. [26] This study also found that MvD was not, but focal LC defects were, detected the normal control group. [26] Another study investigated the topographic correlation between juxtapapillary PCT and MvD.…”

Section: Plos Onementioning

confidence: 97%

“…Study findings based on OCT angiography suggest that microvasculature dropout (MvD) is associated with focal LC defects in patients with glaucoma; these findings support the hypothesis that vascular insufficiency is present in these eyes. [24][25][26][27][28][29] MvD is a circumferential area of capillary dropout; its border adjoins the optic disc margin. [24][25][26][27][28][29] These studies found that the location of MvD is topographically associated with focal LC defect locations and that both focal LC defects and MvD are associated with peripapillary atrophy in glaucomatous eyes.…”

Section: Plos Onementioning

confidence: 99%

“…[24][25][26][27][28][29] MvD is a circumferential area of capillary dropout; its border adjoins the optic disc margin. [24][25][26][27][28][29] These studies found that the location of MvD is topographically associated with focal LC defect locations and that both focal LC defects and MvD are associated with peripapillary atrophy in glaucomatous eyes. [24][25][26][27][28][29] The findings of one study also suggested that compared with focal LC defects, the presence of MvD is more strongly associated with glaucoma severity.…”

Section: Plos Onementioning

confidence: 99%

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Focal lamina cribrosa defects and significant peripapillary choroidal thinning in patients with unilateral branch retinal vein occlusion

et al. 2020

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To investigate the prevalence of focal lamina cribrosa (LC) defects in patients with unilateral branch retinal vein occlusion (BRVO) and to compare ocular characteristics between eyes with and without focal LC defect and those eyes with normal-tension glaucoma (NTG). Methods This retrospective, cross-sectional study included 121 patients. Thirty-nine patients had unilateral BRVO (BRVO group), 36 patients had NTG (NTG group), and 36 patients had vitreous floaters, but no other ocular diseases (control group). In addition to baseline characteristics such as age, sex, refractive errors, the ocular characteristics such as peripapillary choroidal thickness (PCT), retinal nerve fiber layer thickness, and subfoveal choroidal thickness were retrospectively analyzed. Results Focal LC defects were detected in 20 eyes of 14 patients (38.9%) in the BRVO group, 24 eyes of 15 patients (41.7%) in the NTG group, and none in the control group (P<0.001). In the BRVO-affected eyes, the mean PCT was 102.7±31.1 μm in the eyes with focal LC defects, and 163.1±70.1 μm in the eyes without LC defects (P = 0.009). In the BRVOaffected eyes, the mean PCT was 102.7±31.1 μm in the eyes with focal LC defects, and 163.1±70.1 μm in the eyes without LC defects (P = 0.009). In the NTG group, the mean PCT was 133.1±48.9 μm in the eyes with focal LC defects and 170.8±81.9 μm in those without (P = 0.042). The other baseline and ocular characteristics were not significantly different between the eyes with and without focal LC defects in both the BRVO group and the NTG group.

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Section: Plos Onesupporting

confidence: 57%