The characteristics, biodistribution, magnetic resonance imaging and biodegradability of superparamagnetic core–shell nanoparticles

High molecular weight chitosan derivative polymeric micelles encapsulating superparamagnetic iron oxide for tumor-targeted magnetic resonance imaging

“…Similar Ms changes were observed in previous studies using SPIONs encapsulated in chitosan derivatives that stably retained the magnetic properties of SPIONs. 33,34 These results indicate that FAPLCS/SPIONs are potentially useful MRI contrast agents.…”

“…Although fluorescence intensity levels in HeLa derived tumors were much higher than those observed in other organs, similar biodistribution patterns have been reported previously. 22,34,39 The greatest obstacle for tumor-targeted MRI is perhaps the accumulation of adequate SPIONs at target sites to produce sufficient contrast for MRI images. 38 In addition to approaches using ligand-conjugated and antibody-conjugated SPIONs, a promising strategy to increase SPION accumulation levels at target sites and improve targeting efficiency is to decrease the SPION size because SPIONs 200 nm in diameter may be rapidly eliminated from the body by the MPS, 27,28 mainly in the liver and spleen.…”

“…18,34,37 Therefore, SPIONs accumulation in tumor cells shortens T 2 relaxation times and thereby results in decreased MRI signal intensities 38 and darkened tumor images in T 2 -weighted MRI images.…”

Preparation and characterization of gadolinium-loaded PLGA particles surface modified with RGDS for the detection of thrombus

“…These preparations have been confirmed to have low biological toxicity via the study of their physical and chemical characteristics, and distribution and degradation in vivo in animal models. [15][16][17] They can be imaged using 1.5 T MR scanners, and their imaging capabilities have been demonstrated to be similar to those associated with the separate use of Gd-DTPA or superparamagnetic iron oxide. Faranesh et al 18 reported that vascular endothelial growth factor (VEGF) and Gd-DTPA were encapsulated into PLGA particles in the preparation of a multifunctional contrast agent which was intended to allow the simultaneous detection and treatment of ischemic disease.…”

“…17 Experiments suggest that PLGA particles coated with CS can significantly shorten clot lysis times, a potential beneficial effect of CS on blood clot lysis. 21 The specific binding of activated platelets and fibrinogen is part of the final pathway of thrombosis.…”