The Characteristic Manifestations of Digestive Tract Disorders in Children With Connective Tissue Dysplasia

Иванова, И. И.; Гнусаев, С. Ф.; Апенченко, Ю. С.; Капустина, Л. В.; Герасимов, Н. А.; Солдатова, И. А.

doi:10.15690/vsp.v11i5.428

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…Несмотря на современные методы диагностики и лечения заболеваний пищеварительной системы, изменения со стороны желудочно-кишечного тракта остаются одной из ведущих проблем у детей с ревматическими заболеваниями, в частности с ЮРА [6,8].…”

Section: актуальностьunclassified

“…По данным литературы, основными проявлениями ДСТ у таких детей являются: деформация желчного пузыря, гастроптоз, гастроэзофагеальный и дуоденогастральный рефлюкс, долихосигма и др. [2,3,6].…”

Section: актуальностьunclassified

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Cardiac and Visceral Signs of Connective Tissue Dysplasia in Children with Juvenile Rheumatoid Arthritis According to Ultrasound Examination Data

Юсуфов

Черкасова

Lavrova

et al. 2021

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To study the cardiac and visceral signs of connective tissue dysplasia in children with juvenile rheumatoid arthritis, a comprehensive ultrasound examination of the abdominal cavity organs and echocardiography examination were conducted according to the standard protocol in 52 children aged from 5 to 16 years with the diagnosis of juvenile rheumatoid arthritis. The reference group consisted of 26 patients with autonomic dysfunction (vegetative-vascular dystonia). The incidence of such visceral dysplasia types as duodenogastric reflux, gastroesophageal reflux, and gallbladder malformations among children with juvenile rheumatoid arthritis was shown higher than in the reference group. The main cardiac sign of connective tissue dysplasia in patients with juvenile rheumatoid arthritis are an excessive chord of the left ventricle.

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Section: актуальностьunclassified

Cardiac and Visceral Signs of Connective Tissue Dysplasia in Children with Juvenile Rheumatoid Arthritis According to Ultrasound Examination Data

Юсуфов

Черкасова

Lavrova

et al. 2021

jour

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“…Согласно данным литературы определенный вклад в развитие заболевания вносят дефициты витаминов группы В, витамина С, витамина Е, макроэлементы (кальций, фосфор) и микроэлементы (медь, цинк, селен, марганец, фтор, ванадий, кремний, бор), являющиеся ко-факторами метаболических реакций СТ. Определенную роль в развитии ДСТ отводят дефициту магния, которым страдают до 76% больных [19,20,21]. В настоящее время активно изучается роль ферментативно активной кишечной микробиоты в метаболизме СТ и ее деструкции, что может влиять на формирование признаков ДСТ [22].…”

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Functional state of the digestive organs in patients with celiac desease associatedFunctional state of the digestive organs in patients with celiac desease associated with connective tissue dysplasia with connective tissue dysplasia

Орешко¹,

Семенова

Орешко

2021

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The article presents the results of our own research devoted to the study of the functional characteristics of the digestive system in patients with celiac disease associated with connective tissue dysplasia (CTD).Materials and methods. The study included 90 patients from the register of adults with celiac disease. To assess CTD, patients underwent clinical and laboratory- instrumental examination, including ultrasound of the abdomen organs, kidneys and heart, EGDS. The assessment of the functional state of the gastrointestinal tract was carried out according to the ultrasound data of the abdomen organs, coprogram and PEGEG.Results. The results of the study showed that all patients had signs of CTD with involvement of at least two organ systems. The most common visceral stigmas of dysplasia were MVP (66.7%), gallbladder anomalies (53.3%), tracheobronchial dyskinesia (35.6%) and signs of nephroptosis (30.0%). Anomalies of the gallbladder included single bends in the body area — 26 people (28.9%) and in the neck area –5 people (5.6%), and double bend — S-shaped gallbladder — 17 people (18.9%). At the same time, an increase in the proportion of gallbladder anomalies was revealed as the severity of CTD increased, with significant differences in the groups in patients with an S-shaped gallbladder (p<0.05), which correlated with biliary sludge and signs of maldigestion. According to PEGEG data, an increase in tonic activity (Pi / Ps) at the frequency of the duodenum with an increase in the degree of CTD was revealed, with the maximum values in group 3 patients being 3.84 ± 1.03, which reflects the presence of hypertensive dysfunction.Conclusion. The functional state of the digestive system in celiac patients with signs of CTD is characterized by disorders of the gastroduodenal complex and the biliary system. A high degree of CTD in celiac disease patients should be considered as an independent risk factor for motor disorders of the upper gastrointestinal tract and biliary system, which must be taken into account when carrying out therapeutic and prophylactic measures.

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Manifestations of mitochondrial dysfunction in children with connective tissue dysplasia and chronic gastroduodenitis

Иванова

Гнусаев

Сухоруков

et al. 2019

Ross. vestn. perinatol. pediatr.

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According to the literature, signs of mitochondrial dysfunction are found in 15–20% of children in the population. It often accompanies physical illness. The digestive tract is an energy-intensive system of organs, so violations of energy metabolism affect its functioning. The aim of this study was to determine the basal level of carnitine and its fractions in children with connective tissue dysplasia and chronic gastroduodenitis and to evaluate their dynamics after L-carnitine therapy. 77 children with this somatic pathology were examined. Depending on the presence of connective tissue dysplasia, they were divided into 2 groups – the main and the comparison group. Blood levels of total and bound carnitine were determined in all patients using liquid tandem chromatomass-spectrometry. Free carnitine was calculated as the difference between total and bound. It was found that in children with connective tissue dysplasia basal levels of total carnitine and its fractions are significantly lower than in patients of the comparison group. Carnitine and fractions increased in all children after a 30-day course of therapy with L-carnitine, reaching normal values with a reduced basal level. The degree of increase in indicators was greater in patients with initially lower levels, which was observed primarily in a group with connective tissue dysplasia. This study showed that connective tissue dysplasia in most cases is accompanied by mitochondrial dysfunction. Most patients with connective tissue dysplasia and chronic gastroduodenitis require correction of energy metabolism disorders using energy-stimulating therapy.

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The Characteristic Manifestations of Digestive Tract Disorders in Children With Connective Tissue Dysplasia

Cited by 6 publications

References 5 publications

Cardiac and Visceral Signs of Connective Tissue Dysplasia in Children with Juvenile Rheumatoid Arthritis According to Ultrasound Examination Data

Cardiac and Visceral Signs of Connective Tissue Dysplasia in Children with Juvenile Rheumatoid Arthritis According to Ultrasound Examination Data

Functional state of the digestive organs in patients with celiac desease associatedFunctional state of the digestive organs in patients with celiac desease associated with connective tissue dysplasia with connective tissue dysplasia

Manifestations of mitochondrial dysfunction in children with connective tissue dysplasia and chronic gastroduodenitis

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