The changing health needs of the UK population

McKee, Martin; Dunnell, Karen; Anderson, Michael; Brayne, Carol; Charlesworth, Anita; Johnston-Webber, Charlotte; Knapp, Martin; McGuire, Alistair; Newton, J.O.; Taylor, David G.; Watt, Richard G.

doi:10.1016/s0140-6736(21)00229-4

Cited by 28 publications

(19 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A further consequence of population ageing is the increase in multimorbidity,456 conventionally defined as the presence of two or more chronic diseases irrespective of the severity of such conditions. Recent estimates suggest that more than 50% of older adults in high income countries report multiple chronic conditions, although multimorbidity is not confined to older adults 45.…”

Section: Introductionmentioning

confidence: 99%

Association between age at onset of multimorbidity and incidence of dementia: 30 year follow-up in Whitehall II prospective cohort study

Hassen

Fayossé

Landré

et al. 2022

BMJ

View full text Add to dashboard Cite

Objective To examine the association of midlife and late life multimorbidity, including severity of multimorbidity, with incident dementia. Design Prospective cohort study. Setting Civil service departments in London (Whitehall II study, study inception in 1985-88). Participants 10 095 participants, aged 35 to 55 at baseline. Main outcome measure Incident dementia at follow-up between 1985 and 2019. Cause specific Cox proportional hazards regression was used to examine the association of multimorbidity overall and at age 55, 60, 65, and 70 with subsequent dementia, taking into account the competing risk of death. Results The prevalence of multimorbidity (≥2 chronic diseases) was 6.6% (655/9937) at age 55 and 31.7% (2464/7783) at age 70; 639 cases of incident dementia occurred over a median follow-up of 31.7 years. After adjustment for sociodemographic factors and health behaviours, multimorbidity at age 55 was associated with subsequent risk of dementia (difference in incidence rate per 1000 person years 1.56, 95% confidence interval 0.62 to 2.77; hazard ratio 2.44, 95% confidence interval 1.82 to 3.26). The association weakened progressively with older age at onset of multimorbidity. At age 65, onset of multimorbidity before age 55 was associated with 3.86 (1.80 to 6.52) per 1000 person years higher incidence of dementia (hazard ratio 2.46, 1.80 to 2.26) and onset between 60 and 65 was associated with 1.85 (0.64 to 3.39) per 1000 person years higher incidence (1.51, 1.16 to 1.97). Severity of multimorbidity (≥3 chronic diseases) at age 55 was associated with a 5.22 (1.14 to 11.95) per 1000 person years higher incidence of dementia (hazard ratio 4.96, 2.54 to 9.67); the same analyses at age 70 showed 4.49 (2.33 to 7.19) per 1000 person years higher incidence (1.65, 1.25 to 2.18). Conclusion Multimorbidity, particularly when onset is in midlife rather than late life, has a robust association with subsequent dementia. The increasingly younger age at onset of multimorbidity makes prevention of multimorbidity in people with a first chronic disease important.

show abstract

Section: Introductionmentioning

confidence: 99%

Association between age at onset of multimorbidity and incidence of dementia: 30 year follow-up in Whitehall II prospective cohort study

Hassen

Fayossé

Landré

et al. 2022

BMJ

View full text Add to dashboard Cite

show abstract

“…They were selected according to their expertise and exposure to pharmaceutical research and policy in the UK over the last two decades. The LSE-Lancet Commission produced a series of working papers that take a similar format to this paper on issues related to workforce [7] , changing health needs [8] , digital health [9] , and financing [10] . The final commission report, recommendations, and complete list of health policy experts is also publicly available [11] .…”

Section: Methodsmentioning

confidence: 99%

Promoting innovation while controlling cost: The UK's approach to health technology assessment

et al. 2022

Self Cite

View full text Add to dashboard Cite

“…Some of the common demographic factors considered in these studies are age, gender, connubial status, educational position, income, occupation, and place of hearthstone. Although limited, existing time-series studies have also explored the implications of broader demographic trends similar as changes in population growth and viscosity 12,13 , population aging 14,15 , and migration [16][17][18][19] . Specially, the studies on population aging point out a two way relationship with AMR.…”

Section: Factors Driving Amrmentioning

confidence: 99%

Review on designing a comprehensive macroeconomic modeling strategy for antimicrobial resistance

Gone¹,

Darla²,

K³

2022

World J. Adv. Res. Rev.

View full text Add to dashboard Cite

Antimicrobial resistance (AMR) is a dominant and growing global health crisis that led to1.27 million deaths in 2019. Given the broad use of antimicrobials in agriculture and farming and industrial operations in addition to healthcare and a range of factors affecting AMR, including climate variability, demographic trends, and plastic and essence pollution, an frugality-wide approach is essential to assess its macroeconomic counter accusations. This study summarizes the being literature on the linked factors driving AMR and reviews the factors that have been considered in being macroeconomic studies. We present three fabrics to conceptualize the frugality-wide use of antimicrobials, the epidemiology of AMR, and how AMR affects the economy in a stylized frugality bedded within a more expansive system. We propose how the AMR impacts could be counterplotted onto profitable variables, bandy the significance of these shocks, and outline how AMR elaboration scripts could be designed, particularly with reference to climate change, demographic trends, and associated socioeconomic changes. We also bandy how modeling studies could be bettered to increase their mileage to policymakers and increase similarity across studies. We conclude with the major policy counter accusations arising from the study which emphasizes an frugality-wide one- health approach to address AMR; regulation of the antimicrobial force chain and incentivizing inventions; global cooperation to address AMR, and easing misgivings for policymaking via spanning up the surveillance of AMR, encouraging exploration collaboration and enabling access to data on AMR and antimicrobial consumption.

show abstract

The changing health needs of the UK population

Cited by 28 publications

References 75 publications

Association between age at onset of multimorbidity and incidence of dementia: 30 year follow-up in Whitehall II prospective cohort study

Association between age at onset of multimorbidity and incidence of dementia: 30 year follow-up in Whitehall II prospective cohort study

Promoting innovation while controlling cost: The UK's approach to health technology assessment

Review on designing a comprehensive macroeconomic modeling strategy for antimicrobial resistance

Contact Info

Product

Resources

About