The Changing Epidemiology of Thyroid Cancer

“…The study groups were representative of thyroid cancer patients with regard to distribution of age, gender and histological subtypes (19 (2). We found that the short-term hypothyroidism resulting from thyroid hormone withdrawal causes physical symptoms in the majority of patients.…”

Section: Discussionmentioning

confidence: 99%

Health-related quality of life, anxiety and depression in thyroid cancer patients under short-term hypothyroidism and TSH-suppressive levothyroxine treatment

Tagay¹,

Herpertz

Langkafel³

et al. 2005

eur j endocrinol

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Objective: Very few previous studies have compared the degree of health-related quality of life (HRQL), depression and anxiety of differentiated thyroid cancer patients (DTC) under short-term hypothyroidism and levothyroxine treatment. Methods: Using patient-completed instruments, we examined the frequency of physical complaints, HRQL, anxiety and depression in 130 DTC patients hospitalized for radioiodine therapy or wholebody diagnostics (age 52 years, female 71%) under short-term hypothyroidism (4 weeks of levothyroxine withdrawal; DTC-H) and in 100 DTC out-patients under TSH-suppressive doses of levothyroxine subsequent to radioiodine therapy (DTC-L; age 49 years, female 81%). Results: Compared with the German general population, DTC-H as well as DTC-L patients had significantly impaired HRQL. Notably, the decrease in HRQL was significantly higher in DTC-H than in DTC-L patients. Surprisingly, the prevalence of anxiety (44.6%) but not depression (17.7%) was much higher in the DTC-H patients than in the general population. In contrast to expectations, similar results for anxiety (44.0%) and depression (17.6%) were observed in the DTC-L patients. Conclusions: This mounting evidence suggests that a consistent pattern of HRQL impairment is experienced by patients with DTC. The high frequency of anxiety and the significantly reduced HRQL should be considered in the aftercare of DTC patients.

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“…Eigenschaften Das C-Zell-Karzinom der Schilddrüse ist ein im Vergleich zu den papillären und follikulären Karzinomen seltenerer von den parafollikulären C-Zellen ausgehender Tumor (Vorkommen 1 ± 10 % der Schilddrüsentumoren) [2], der sporadisch oder familiär gehäuft auftreten kann. Die Prognose der sporadischen Form ist im Vergleich ungünstiger, da die Primärtumordiagnose häufig später als bei familiären Formen aufgrund klinischer Symptome gestellt wird, und oftmals schon Lymphknotenmetastasen präsent sind [23].…”

Section: C-zell-karzinomeunclassified

“…Insgesamt ist ein Zuwachs der Inzidenzen bei beiden Geschlechtern festzustellen, wobei bei papillären Karzinomen eine Zunahme der Inzidenzen und bei anaplastischen Karzinomen eine Abnahme zu verzeichnen ist. Als mögliche Ursache für diese Verschiebung wird die bessere Jodversorgung diskutiert [2]. In Deutschland liegt die altersgemittelte Mortalitätsrate für Männer bei 0,54 für Frauen bei 0,65 [3].…”

Section: Introductionunclassified