Health-related Quality of Life, Depression and Anxiety in Thyroid Cancer Patients

Tagay, Sefik; Herpertz, Stephan; Langkafel, Mathias; Erim, Yeşim; Bockisch, Andreas; Senf, Wolfgang; Görges, Rainer

doi:10.1007/s11136-005-3689-7

Cited by 107 publications

(87 citation statements)

References 29 publications

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“…Hypothyroidism is associated with a high prevalence of clinical symptoms, such as neuromuscular dysfunction, paresthesia, fatigue, dry skin and cold intolerance [21] . Furthermore, psychiatric disturbances like anxiety and depression [22] also have been described [16,[23][24][25] . Bianchi et al [16] related that the presence of fatigue and psychiatric disturbances was negatively associated with quality of life scores in patients with overt hypothyroidism.…”

Section: Discussionmentioning

confidence: 99%

“…Gerding et al [23] and Ljunggren et al [24] noted a relation between less favorable health status scores and the presence of clinical signs in patients with hyperthyroidism. Tagay et al [25] examined the health status in differentiated thyroid cancer patients under short-term hypothyroidism and observed that it was severely impaired in this population (in comparison to the general population). Also, health status was correlated significantly with worse scores in the scale of signs and symptoms.…”

Section: Discussionmentioning

confidence: 99%

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Perceived Health Status of Women with Overt and Subclinical Hypothyroidism

et al. 2009

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Objective: The objective of this study was to investigate the health status of women with overt and subclinical hypothyroidism and relate it to the presence of clinical signs and symptoms of the disease. Subjects and Methods: A cross-sectional study was conducted on 232 women divided into 3 groups: overt hypothyroidism (n = 14); subclinical hypothyroidism (n = 152), and controls (n = 66). Health status was evaluated by the questionnaire SF-36, and the clinical signs and symptoms of hypothyroidism were assessed with the Billewicz scale modified by Zulewski. The Kruskal-Wallis test followed by the Mann-Whitney U test with Bonferroni correction was applied to compare continuous variables between the groups. To assess the relationship between SF-36 domains and the clinical score, as well as SF-36 domains and serum thyroid-stimulating hormone levels, the Spearman correlation coefficient was calculated. Results: Patients with overt hypothyroidism presented systematically lower scores in all SF-36 domains (p < 0.05), both in relation to subclinical hypothyroidism patients and controls. This indicates a great dissatisfaction with health status in this group. Patients with subclinical hypothyroidism presented statistically lower scores in relation to controls with the exception of the role-emotional and bodily pain domains, where although they were not statistically significant, scores were clinically different. Highly negative correlations between SF-36 domains and the clinical score were observed in overt hypothyroidism (physical function r = –0.80, p < 0.01; bodily pain r = –0.74, p < 0.01). Conclusion: Overt hypothyroidism seemed to be associated with worse perception of health status, negatively associated with clinical score.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Perceived Health Status of Women with Overt and Subclinical Hypothyroidism

et al. 2009

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“…A associação entre qualidade de vida, ansiedade e depressão em pacientes com câncer (Jorngarden, Mattsson & Von Essen, 2007;Mystakidou, Tsilika, Parpa, Katsouda, Galanos & Vlahos, 2005;Tagay et al, 2006), e entre qualidade de vida e sexualidade (Fobair, Stewart, Chang, D'onofrio, Banks, Bloom, 2006;Frumovitz et al, 2005;Huget et. al, 2009) foi demonstrada na literatura internacional, porém até então, não foram encontrados dados relacionando todos esses aspectos na literatura latinoamericana.…”

Section: Tabla 2 Resultados Descritivos Do Instrumento De Qualidade unclassified

Quality of life, anxiety and depressions indicators and sexual satisfaction in adult patients with cancer.

Bertan

Castro

2010

Salud soc.

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RESUMOObjetivo: avaliar a qualidade de vida, indicadores de ansiedade e depressão e a satisfação sexual de pacientes com câncer. Participantes: 82 pacientes com idade média de 38,99 (DP= 7,47 ABSTRACTPurpose: evaluate quality of life, anxiety, depression and sexual satisfaction indicators in patients with cancer. Participants: 82 patients with average age of 38,99 (DP=7,47) . Instruments: Whoqol-bref, GHQ-12 and a Sexual Satisfaction Questionnaire. Results: Quality of life, anxiety, depression and sexual satisfaction indicators were significantly correlated. Patients submitted to radiotherapy presented better quality of life than non-submitted patients. Anxiety and depression indicators were significantly predictors of quality of life. Findings showed a close relation among these variables and the necessity to study quality of life to improve their well-being.

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“…Moreover, socioeconomic burdens including sick leave from work, as well as physical suffering, are markedly increased in all patients undergoing this procedure for thyroid cancer management [12]. To make things worse, some patients experiencing acute short-term hypothyroid symptoms after THW also experience major psychiatric derangements, such as depression or anxiety, and the severity of the disease is comparable to that of patients with major depression requiring regular treatment [11,13]. …”

Section: Discussionmentioning

confidence: 99%

Differences in Physicians' and Patients' Perception of Acute Hypothyroid Symptoms Induced by Thyroid Hormone Withdrawal in Thyroid Cancer Patients: A Multicenter Survey in Korea

Lim

Kim

et al. 2015

Eur Thyroid J

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Background: Acute short-term hypothyroidism induced by thyroid hormone withdrawal (THW) for follow-up surveillance or therapeutic radioiodine causes patients with differentiated thyroid cancer to suffer from a myriad of deleterious symptoms. Objectives: To know how patient recognition of hypothyroid symptoms compares to physician perception of patient symptoms. Methods: The survey was performed in 10 referral hospitals throughout Korea from December 2010 to May 2011 and targeted patients with total thyroidectomy and remnant ablation. The survey consisted of questions regarding the effect of THW on patient symptoms, the duration of symptoms, impact on social life, and patient complaints. The physicians treating thyroid cancer patients also responded to the survey and provided their perceptions of patient symptoms and treatment decisions. Results: About 70% of the patients responded that they experienced a negative physical or psychological impact on their life and work due to hypothyroid symptoms. However, 76% of doctors thought hypothyroidism could negatively impact a patient's daily life but would be endurable. Two thirds of physicians do not routinely recommend recombinant human TSH (rhTSH) to their patients. Multivariate analysis showed patients with female sex, stronger educational background, emotionally negative experiences of hypothyroidism, and younger age were more willing to pay for therapy that could prevent hypothyroidism symptoms. Conclusions: There was a substantial gap in the perception of hypothyroid symptoms during THW between physicians and patients. Physicians who are aware of the seriousness of hypothyroidism in their patients were more likely to recommend the use of rhTSH for their patients.

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Health-related Quality of Life, Depression and Anxiety in Thyroid Cancer Patients

Cited by 107 publications

References 29 publications

Perceived Health Status of Women with Overt and Subclinical Hypothyroidism

Perceived Health Status of Women with Overt and Subclinical Hypothyroidism

Quality of life, anxiety and depressions indicators and sexual satisfaction in adult patients with cancer.

Differences in Physicians' and Patients' Perception of Acute Hypothyroid Symptoms Induced by Thyroid Hormone Withdrawal in Thyroid Cancer Patients: A Multicenter Survey in Korea

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