The changes of oxidative stress and human 8-hydroxyguanine glycosylase1 gene expression in depressive patients with acute leukemia

Zhou, Fuling; Zhang, Wanggang; Wei, Yongchang; Zhou, Daohong; Su, Zhixing; Meng, Xin; Hui, Lingyun; Tian, Wei

doi:10.1016/j.leukres.2006.07.014

Cited by 42 publications

(42 citation statements)

References 45 publications

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“…A body of clinical evidence indicates that depression is characterized by a higher oxidant status. In fact, total oxidant status (TOS) and oxidative stress index (OSI) were increased in depressed patients as compared to normal controls in plasma [3,4] and serum [5,6]. Some studies demonstrated higher levels of plasma peroxides [7] and serum nitric oxide (NO) [5,6,[8][9][10] in depressed patients, while Ozcan and co-workers reported lowered levels of NO in depressed patients in the pre-treatment period [11].…”

Section: Psychiatric Disordersmentioning

confidence: 99%

“…In depressed patients, markers of lipid peroxidation were increased [5,6,11,[14][15][16][17][18], especially during depressive episodes [3], while elevated levels of isoprostanes were present in urine [19,20], serum [21] and plasma [17]. Oxidative DNA damage was detected in serum [5,6,16,22], leukocytes [23] and urine [24], while higher protein peroxidation was seen in plasma [25] of depressed patients.…”

Section: Psychiatric Disordersmentioning

confidence: 99%

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Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism

Smaga

Niedzielska

Gawlik

et al. 2015

Pharmacological Reports

216

115

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The pathophysiology of psychiatric diseases, including depression, anxiety, schizophrenia and autism, is far from being fully elucidated. In recent years, a potential role of the oxidative stress has been highlighted in the pathogenesis of neuropsychiatric disorders. A body of clinical and preclinical evidence indicates that psychiatric diseases are characterized by higher levels of oxidative biomarkers and with lower levels of antioxidant defense biomarkers in the brain and peripheral tissues. In this article, we review current knowledge on the role of the oxidative stress in psychiatric diseases, based on clinical trials and animal studies, in addition, we analyze the effects of drug-induced modulation of oxidative balance and explore pharmacotherapeutic strategies for oxidative stress reduction.

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Section: Psychiatric Disordersmentioning

confidence: 99%

Section: Psychiatric Disordersmentioning

confidence: 99%

Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism

Smaga

Niedzielska

Gawlik

et al. 2015

Pharmacological Reports

216

115

View full text Add to dashboard Cite

show abstract

“…The cellular and molecular events underlying AML include DNA damage, increased proliferation, deficient cell death, and further genetic instability. There is increasing evidence that the ROS-induced generation of oxidative stress plays a role in leukemia in this multistage process, and interesting results have been reported (17)(18)(19). However, few studies have explicitly examined the biochemical involvement of oxidative stress in the relapse of AML.…”

mentioning

confidence: 99%

Involvement of Oxidative Stress in the Relapse of Acute Myeloid Leukemia

Zhou

Zhang

Wei

et al. 2010

Journal of Biological Chemistry

Self Cite

100

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The aims of the present study were to determine the level of oxidative stress and the salient factors leading to the relapse of acute myeloid leukemia (AML). Oxidative stress-related parameters and the expressions of specific genes were monitored in 102 cases of AML during a pretreatment period from a primary status to a relapse status. In addition, age-matched healthy subjects were classified as controls. The activities of adenosine deaminase and xanthine oxidase were higher in the relapse condition, whereas those of glutathione peroxidase, monoamine oxidase, and superoxide dismutase, and the total antioxidant capacity (T-AOC) were lower in the primary condition and in controls. Of particular note, levels of advanced oxidation protein products, malondialdehyde, and 8-hydroxydeoxyguanosine were also significantly higher in relapse patients. Furthermore, real-time PCR with SYBR Green revealed that the expression levels of human thioredoxin (TRX) and indoleamine 2,3-dioxygenase were increased in relapse patients. Pearson correlation analysis revealed that the T-AOC was positively correlated with GSH but negatively correlated with 8-OHdG, TRX, and indoleamine 2,3-dioxygenase. Linear regression showed that a low T-AOC and up-regulated TRX expression were the independent factors correlated with relapse. A strong association between oxidative stress and the incidence of disease relapse was observed, which has potential prognosis implications. These results indicate that oxidative stress is a crucial feature of AML and probably affects the development and relapse of AML.

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“…[7][8][9][10] Many studies have shown high levels of lipid peroxidation in different types of cancer, including leukemia. [11][12][13] It is known that carcinogenesis is related to three main stages: initiation, promotion and progression of tumor, however, other studies have shown that oxidative stress is involved in these three steps. 14 High levels of lipid peroxidation in newly diagnosed ALL patients suggest these oxidative lesions are related to the pathogenesis and not to chemotherapy, which is quite aggressive to the organism.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Oxidative Stress in Patients with Acute Lymphoblastic Leukemia: Experimental Evidence of the Efficacy of MDA as Cancer Biomarker in Young Patients

Almeida

Carrilho

Nixdorf

2017

J. Braz. Chem. Soc.

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Acute lymphoblastic leukemia (ALL) is a fatal disorder in most cases and is the most common cancer in young patients. ALL features an uncontrolled proliferation and maturation arrest of lymphoid progenitor cells (lymphoblast) in the bone marrow. An increase of reactive species production occurs in ALL with an involvement of oxidative stress (OS) and cellular damage. However, there is a lack of information about variations in young patients. The biomarker widely used to measure the OS is the main product of lipid peroxidation, the malondialdehyde (MDA). This biomarker, when evaluated by a chromatographic method and the data analyzed by multivariate analysis with other biochemical parameters of ALL patient charts, shows the distinction of healthy and ALL patients, and a great correlation with the risk of disease.

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The changes of oxidative stress and human 8-hydroxyguanine glycosylase1 gene expression in depressive patients with acute leukemia

Cited by 42 publications

References 45 publications

Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism

Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism

Involvement of Oxidative Stress in the Relapse of Acute Myeloid Leukemia

Evaluation of Oxidative Stress in Patients with Acute Lymphoblastic Leukemia: Experimental Evidence of the Efficacy of MDA as Cancer Biomarker in Young Patients

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