The Changes of of Cellular Immunity Parameters in Patients With Preinvasive and Microinvasive Cervical Cancer Before and After Treatment

Резюме. Целью исследования явилось изучение особенностей состояния клеточного и гуморального иммунитета и функциональной активности нейтрофильных гранулоцитов у женщин с моноинфекцией вирусом папилломы человека (ВПЧ) и при сочетании папилломавирусной инфекции (ПВИ) и урогенитальных инфекций (УГИ). Установлено, что при сочетанной ПВИ и УГИ у женщин выявляются более выраженные нарушения в иммунной системе, чем при моноинфекции ВПЧ. Только у больных сочетанной ПВИ и УГИ снижается содержание общих лимфоцитов, Т-клеток и цитотоксических Т-лимфоцитов. Со стороны гуморального иммунитета при сочетанной ПВИ и УГИ выявляется повышение концентрации IgM, уровня его относительного синтеза и содержания циркулирующих иммунных комплексов. Независимо от типа инфекции у женщин выявляется снижение содержания CD4 + -лимфоцитов, NK-клеток, повышение количества γδТ-лимфоцитов, а также увеличение функциональной активности нейтрофильных гранулоцитов крови. Однако при сочетанной ПВИ и УГИ выявляется ингибирующее влияние на резервные возможности фагоцитирующих клеток.

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Immunological Parameters in Patients With Monoinfection by Human Papillomavirus and in Patients Co-Infected by Papillomavirus and Urogenital Pathogens

Савченко

Цхай

Круглова

et al. 2014

Russian Journal of Infection and Immunity

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Dynamics of matrix metalloproteinases and their tissue inhibitors in patients with herpesvirus and papillomavirus infection

Nevezhkina,

Chernikova,

Markelova

et al. 2023

Russian Journal of Immunology

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Sexually transmitted infections are of great importance for the proper reproductive function in women. Chronic inflammatory process leads to reproductive disorders. A special role in the chronic inflammatory process is attributed to papillomavirus (PVI) and herpetic infection. MMP-2 and MMP-9 enzymes cleave type 4 collagen which makes the scaffold of basement membranes and contributes to the separation of endothelial cells from the membranes, followed by their further migration and direct participation in angiogenesis thus affecting the growth of tumors, in particular cervical cancer. Tissue inhibitors of matrix metalloproteinases are known to limit the collagen breakdown. However, the imbalance of MMP and TIMP is accompanied by accumulation of extracellular matrix and increased risk for reproductive disorders. The aim of our study was to evaluate the dynamics of acute-phase proteins affecting the state of intercellular matrix (MMP-2, MMP-9 and MMP tissue inhibitors (type 1, 2) in blood serum of patients with PVI or coinfection of PVI and HSV before and after therapy with drugs exhibiting antiviral and immunomodulatory effects, i.e., a synthetic compound (Inosine pranobex) and vegetable substance (Solanum tuberosum). We have examined 141 patients with papillomavirus and herpetic infections treated with Inosine pranobex and Solanum tuderosum. Determination of MMP-2, MMP-9 and TIMP-1, TIMP-2 levels of in blood serum was carried out using specific reagents from RD Diagnostics Inc. (USA). The drug therapy with active substances of Inosine pranobex and Solanum tuberosum was associated with positive dynamics of the level of MMP-2, MMP-9 and tissue inhibitors of types 1 and 2 in all groups under studies. However, Inosine Pranobex exerts more pronounced changes, especially in subgroups with viral coinfections.

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The Changes of of Cellular Immunity Parameters in Patients With Preinvasive and Microinvasive Cervical Cancer Before and After Treatment

Cited by 2 publications

References 17 publications

Immunological Parameters in Patients With Monoinfection by Human Papillomavirus and in Patients Co-Infected by Papillomavirus and Urogenital Pathogens

Immunological Parameters in Patients With Monoinfection by Human Papillomavirus and in Patients Co-Infected by Papillomavirus and Urogenital Pathogens

Dynamics of matrix metalloproteinases and their tissue inhibitors in patients with herpesvirus and papillomavirus infection

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