The Changes of CTX, DPD, Osteocalcin, and Bone Mineral Density During the Postmenopausal Period

Abstract

ObjectiveTo investigate appropriate treatment time and useful bone turnover markers (BTMs) for monitoring bone turnover during the postmenopausal period, we analyzed changes of two bone resorption markers; serum carboxyterminal telopeptide of collagen I (s-CTX), urine deoxypyridinoline (u-DPD), one bone formation marker; serum osteocalcin (s-OC), and bone mineral density (BMD) in Korean postmenopausal women.MethodsSeventy-eight menopausal women were divided into three groups according to postmenopausal period: group I (0–5 years), group II (6–10 years), group III (≥10 years). All groups were subdivided into an osteoporosis group (T-score≤-2.5) and a non-osteoporosis group (T-score>-2.5). BTMs such as s-CTX, u-DPD, s-OC, and BMD (g/cm2) were measured by dual-energy X-ray absorptiometry (DXA) in all patients. Analysis of variables among groups based on the postmenopausal period was performed using ANOVA.ResultsThere was significant negative correlation between BMD and postmenopausal period. The levels of all BTMs including s-CTX, u-DPD, and s-OC were highest in group II and the increased levels of all BTMs subsequently declined in group III. The levels of BTMs were higher in the osteoporosis groups than in the non-osteoporosis groups in all subjects. It was statistically significant that the level of s-CTX in group I was higher in the osteoporosis group than in the non-osteoporosis group.ConclusionThis study showed that bone resorption and bone formation were the highest 5–10 years after menopause, and s-CTX is more useful than u-DPD among the bone resorption markers. It’s important to measure serially both BMD and BTM within 10 years after menopause for accurate diagnosis and management for postmenopausal osteoporosis.

Gut microbiota and metabolite alterations associated with reduced bone mineral density or bone metabolic indexes in postmenopausal osteoporosis

“…In concert with decreases in estrogen, both bone formation and bone resorption are greatest at 7-8 years after menopause [30], correlating well with the acceleration of bone turnover observed in the osteopenia and osteoporosis groups in the present study. Moreover, osteoporosis group individuals had lower BMD than both control and osteopenia group individuals, and the cumulative loss was greater at the lumbar spine than at the hip.…”

The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review

“…They are ideal tools to evaluate the actual metabolic status of the bone, as well as a well-established result of abnormal metabolism (5). Table 1 shows the most reviewed bone biomarkers to assess the different phases of bone metabolism process (4,(6)(7)(8)(9)(10)(11).…”

Folate and Vitamin B‐12 Status Is Associated With Bone Mineral Density and Hip Strength of Postmenopausal Chinese‐Singaporean Women

“…It has been shown that bone resorption reaches its peak in 5 to 10 years after the onset of postmenopause compared with the years before and after that timeframe. (43) In the aforementioned study, (39) the women were postmenopausal for at least a year, whereas in our study, for at least 5 years. Thus, we could argue that the observed relationship between folate and CTx-1 in these two studies was affected by the years since the onset of postmenopause, as well as possible differences in diet, considering that the two cohorts resided in different geographic locations.…”