The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review

Marini, Sofia; Barone, Giuseppe; Masini, Alice; Dallolio, Laura; Bragonzoni, Laura; Longobucco, Yari; Maffei, Francesca

doi:10.3389/fendo.2020.585689

Cited by 24 publications

(14 citation statements)

References 47 publications

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“…Clinically, ALP is often used to reflect bone metabolism activity and monitor drug response after treatment. 18,21,24,26 In our study, the 1 year ALP in Group 2 declined, which reflected a good response of the body to drugs to a certain extent. Compared to bone, the prostate is the primary source of ACP and PACP (the level of NACP is equal to ACP minus PACP).…”

Section: Discussionsupporting

confidence: 49%

“…Only approximately half of ALP in healthy adult blood comes from bone, which shows a lack of specificity. Clinically, ALP is often used to reflect bone metabolism activity and monitor drug response after treatment 18,21,24,26 . In our study, the 1 year ALP in Group 2 declined, which reflected a good response of the body to drugs to a certain extent.…”

Section: Discussionmentioning

confidence: 48%

“…We also studied the differences in smoking, drinking, and physical activity among women with different BMD changes (Table 2 ), and confirmed that appropriate physical activity is beneficial to the maintenance of and positive change in BMD (Table 5 ). 17 , 18 Smoking and drinking have been also reported to be associated with the impairment of bone remodeling, and were known risk factors for the decrease of BMD. 19 , 20 However, in our present study, smoking had an insignificant association with LS 1-4 BMD change, and the statistical differences of the logistic regression analysis of alcohol intake was not significant either.…”

Section: Discussionmentioning

confidence: 99%

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Declining serum bone turnover markers are associated with the short-term positive change of lumbar spine bone mineral density in postmenopausal women

Zhao

Wen

et al. 2022

Menopause

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Objective: While serum bone turnover markers (BTMs) and bone mineral density (BMD) have been confirmed as useable risk assessment tools for postmenopausal osteoporosis, the associations between BTMs and BMD changes are still ambiguous. The aim of this study was to explore the underlying associations between BTMs and BMD changes in postmenopausal women. Methods: Between January 2015 and October 2020, 135 postmenopausal women were retrospectively enrolled. They were divided into two groups according to lumbar spine (LS) 1-4 BMD change (1 y T-score minus baseline T-score, Group 1 [ n = 36] < 0 and Group 2 [ n = 99] ≥ 0). The changes of BTMs (N-terminal middle segment osteocalcin [N-MID], propeptide of type I procollagen [P1NP], and β-C-terminal telopeptide of type I collagen [β-CTX]) and their associations with LS 1-4 BMD change were analyzed. The biochemical indices and clinical parameters related with LS 1-4 BMD change were also evaluated. Results: The 1 year N-MID, P1NP, β-CTX and Phosphorus in Group 2 were lower than those in Group 1 ( P < 0.05), their changes within 1 year were significantly negatively correlated with LS 1-4 BMD change ( R 2 = –0.200, P < 0.001; R 2 = –0.230, P < 0.001; R 2 = –0.186, P < 0.001; R 2 = –0.044, P = 0.015; respectively). Except for the Phosphorus change (area under the curve [AUC] = 0.623), the changes of N-MID, P1NP, and β-CTX and their 1 year levels had similar AUC to diagnose the short-term LS 1-4 BMD change (AUC > 0.7 for all, with the AUC of 1 y P1NP being the largest at 0.803). Binary logistic regression analysis showed that the physical activity and drug intervention were the determinant factors for the LS 1-4 BMD change (odds ratio = 6.856, 95% confidence interval: 2.058-22.839, P = 0.002; odds ratio = 5.114, 95% confidence interval: 1.551-16.864, P = 0.007; respectively). Conclusions: Declining N-MID, P1NP, β-CTX, and Phosphorus are associated with the short-term increase of LS 1-4 BMD within 1 year. Physical activity and drug intervention are factors significantly influencing the change of LS 1-4 BMD in postmenopausal women.

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%

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Declining serum bone turnover markers are associated with the short-term positive change of lumbar spine bone mineral density in postmenopausal women

Zhao

Wen

et al. 2022

Menopause

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“…A systematic review of BTMs in subjects with osteoporosis revealed possible exercise benefits in terms of improving bone formation and decreasing bone resorption biomarkers ( 32 ). Whereas some studies have reported beneficial acute effects of exercise on BTMs ( 17 , 22 , 33 ), a direct comparison of heavy resistance training and aerobic running exercise has not yet been performed under strictly controlled conditions.…”

Section: Introductionmentioning

confidence: 99%

Acute Effects of Strength and Endurance Training on Bone Turnover Markers in Young Adults and Elderly Men

et al. 2022

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ContextExercise is recognized as an important strategy to prevent bone loss, but its acute effects on bone turnover markers (BTMs) and related markers remain uncertain.ObjectiveTo assess the acute effects of two different exercise modes on BTMs and related markers in young adults of both sexes and elderly men.Design, Setting, ParticipantsThis was a three-group crossover within-subjects design study with a total of 53 participants—19 young women (aged 22–30), 20 young men (aged 21–30 years), and 14 elderly men (aged 63–74 years)—performing two different exercise sessions [strength training (ST) and high-intensity interval training (HIIT)] separated by 2 weeks, in a supervised laboratory setting.Main Outcome MeasuresPlasma volume-corrected serum measurements of the BTMs C-terminal telopeptide of type 1 collagen (CTX-I) and procollagen of type 1 N-terminal propeptide (P1NP), total osteocalcin (OC), sclerostin, and lipocalin-2 (LCN2) at baseline, immediately after, and 3 and 24 h after each of the two exercise modes were performed.Results and ConclusionAnalyses revealed sex- and age-dependent differences in BTMs and related bone markers at baseline and time-, sex-, and age-dependent differences in response to exercise. No differences between exercise modes were observed for BTM response except for sclerostin in young men and LCN2 in elderly men. An acute, transient, and uniform increase in P1NP/CTX-1 ratio was found in young participants, demonstrating that beneficial skeletal effects on bone metabolism can be attained through both aerobic endurance and resistance exercise, although this effect seems to be attenuated with age. The acute effects of exercise on bone-related biomarkers were generally blunted after 24 h, suggesting that persistent alterations following prolonged exercise interventions should be assessed at later time points.

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“…With advancing T age, alveolar elastic fibers degenerate, resulting in impaired gas exchange, respiratory muscle strength, and chest wall compliance indicates overall respiratory deterioration (5). A gradual reduction in bone density, osteoblastic activity and imbalance in bone formation and resorption deteriorates the body physical activity (6). As we get older, our lean body mass decreases while our body fat percentage rises and decline in body mass index, which are associated with ageing.…”

Section: Pathophysiology Of Ageingmentioning

confidence: 99%

Can You be Biologically Younger than Your Chronological Age? An Overview of Biological Ageing

Kumar¹,

Moodithaya²,

I³

et al. 2021

Biomedicine

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The ageing of the population is rapidly escalating worldwide irrespective of unpredictable health challenges like climate change, emerging infectious disease, a microbe that develops drug resistance. India is also experiencing rapid socioeconomic progress and urbanization and the result of this demographic transition is population ageing. Even though there is an increase in life expectancy, there is no increase in health span, and thus increased life expectancy leads to ‘expansion of morbidity'. Longer life expectancy with the expansion of morbidity could enforce a challenge to geroscience as well as a substantial health burden and a threat to the national economy. In normal ageing, chronological age equates to biological age but certain disease conditions accelerate biological age. Similarly, intervention with physical activity, anti-ageing nutraceuticals would slow down the rate ageing process and provide powerful benefits for longevity. The current review article is based on MeSH and free-text terms in databases such as PubMed, the Cochrane Library, and Science Direct. This article aims to provide an overview of the concept of biological ageing with emphasis on the pathophysiology of ageing, quantification of biological ageing and the anti-ageing strategies.

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The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review

Cited by 24 publications

References 47 publications

Declining serum bone turnover markers are associated with the short-term positive change of lumbar spine bone mineral density in postmenopausal women

Declining serum bone turnover markers are associated with the short-term positive change of lumbar spine bone mineral density in postmenopausal women

Acute Effects of Strength and Endurance Training on Bone Turnover Markers in Young Adults and Elderly Men

Can You be Biologically Younger than Your Chronological Age? An Overview of Biological Ageing

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