The Changes and Effects of the Plasma Levels of Tumor Necrosis Factor after Coronary Artery Bypass Surgery with Cardiopulmonary Bypass

Abacilar, Feyzi; Dogan, Omer Faruk; Duman, Umit; Ucar, Ibrahim; Demircin, Metin; Ersoy, Ünsal; Doğan, Rıza; Böke, Erkmen

doi:10.1532/hsf98.20061012

Cited by 14 publications

(10 citation statements)

References 43 publications

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“…Abacilar et al reported a positive correlation between TNF-α level and postoperative mediastinal drainage amount 2. We found a similar relationship between these two parameters in our study, although not statistically significant.…”

Section: Other Parameterssupporting

confidence: 82%

Effects of topical hypothermia on postoperative inflammatory markers in patients undergoing coronary artery bypass surgery : cardiovascular topic

Kadan¹,

Erol²,

Oz³

et al. 2014

CVJA

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SummaryBackgroundWe aimed to examine the effects of topical hypothermia on inflammatory markers in patients undergoing coronary artery bypass surgery.MethodsFifty patients undergoing isolated coronary artery bypass surgery were included the study. They were randomised to two groups. Mild hypothermic cardiopulmonary bypass (28–32°C) was performed on both groups using standardised anaesthesiology and surgical techniques. Furthermore, topical cooling with 4°C saline was performed on patients in group I. We recorded peri-operative and intra-operative results of blood samples, pre-operative and postoperative outcomes of electrocardiography and echocardiography, diaphragm levels on X-ray, and the necessity of positive inotropic medication and intra-aortic balloon pump (IABP).ResultsTime-dependent changes in blood samples were compared between the two groups. The changes on complement 3 (C3) and TNF-α levels were more significant in group I than group II (p < 0.05 and p < 0.001, respectively). Spontaneous restoration rate of sinus rhythm was higher in group II than group I (80 vs 32%, p < 0.01). Atrial fibrillation was seen in six patients in group I and one patient in group II (p < 0.05). IABP was performed on four patients (16%) in group I (p < 0.05). Diaphragmatic paralysis was seen in seven patients in group I but not in group II (p < 0.01). Partial pericardiotomy rates were compared within the groups but there was no statistically significant difference (p > 0.05). One patient in group I died on the 18th postoperative day, but operative mortality rate was not statistically significant between the two groups (p > 0.05).ConclusionsTopical hypothermia had a negative impact on inflammatory markers and postoperative morbidities.

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Section: Other Parameterssupporting

confidence: 82%

Effects of topical hypothermia on postoperative inflammatory markers in patients undergoing coronary artery bypass surgery : cardiovascular topic

Kadan¹,

Erol²,

Oz³

et al. 2014

CVJA

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“…The clinical relevance of CABGrelatedsystemic inflammation varies with patients and such inflammation may be accompanied by intermittent organ dysfunction and finally, multi-organ failure, including renal and pulmonary dysfunction. 9 , 10 …”

Section: Discussionmentioning

confidence: 99%

Telmisartan decreases microalbuminuria in patients with type 2 diabetes mellitus following coronary artery bypass grafting

Furat

Doğan

İlhan

et al. 2017

CVJA

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SummaryObjective:This prospective study aimed to investigate the effects of the selective angiotensin receptor antagonist, telmisartan, on microalbuminuria after coronary artery bypass surgery in patients with diabetes mellitus.Methods:Patients were divided into two groups with block randomisation, using the sealed envelope technique: group T (telmisartan group) consisted of patients who received the angiotensin receptor blocking agent telmisartan 80 mg daily for at least six months in the pre-operative period; group N-T (non-telmisartan group) consisted of patients who received no telmisartan treatment. Clinical and demographic characteristics, operative and postoperative features, microalbuminuria and high-sensitivity C-reactive protein levels were compared.Results:Forty patients met the eligibility criteria for the study. The groups did not differ with regard to clinical and demographic characteristics, and operative and postoperative features. Microalbuminuria levels between the groups differed significantly in the pre-operative period, first hour postoperatively and fifth day postoperatively. C-reactive protein levels between the groups differed significantly on the fifth day postoperatively.Conclusion:Telmisartan was useful for decreasing systemic inflammation and levels of urinary albumin excretion in patients who had type 2 diabetes mellitus and had undergone coronary artery bypass surgery.

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“…TNF-α, bir yandan IL-6 ve IL-8'in sekresyonunu arttırırken, diğer yandan nötrofil ve monositler için kemotaktik etki yaratmakta, ve böylece inflamasyonu arttırmakta-dır. 4 Proinflamatuar sitokinlerin kalp cerrahisi sonrasında görülen AF ile olan ilişkisi hakkında çeşitli çalışmalar yapılmış, ancak mutlak bir ilişki ortaya konulamamıştır. 2,5 Biz bu çalışmamızda TNF-α ile postoperatif dönemde görülen AF arasındaki iliş-kiyi araştırdık.…”

Section: Tnf-α Kalp Cerrahisi Sonrası Görülen Atriyal Fibrilasyon İçiunclassified

Can TNF-α be a Predictor for Atrial Fibrillation After Cardiac Surgery?

Doğancı¹,

Kadan²,

Kaya³

et al. 2013

Turkiye Klinikleri J Med Sci

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A Am ma aç ç: : Kalp cerrahisi sonrası görülen atriyal fibrilasyon etyolojisinde en önemli faktörlerden birinin sistemik inflamatuar yanıt olduğu düşünülmektedir. Çalışmamızda inflamatuar yanıtta önemli bir yeri olan TNF-α'nın kalp cerrahisi sonrasında görülen atriyal fibrilasyon ile olan ilişkisi araştırılmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Üç damar ve daha fazla hedef damara revaskülarizasyon uygulanan 50 hasta çalışmaya dahil edildi. İntraoperatif olarak koroner sinüsten bazal, iskemi ve reperfüzyon dönemlerinde alınan kan ör-neklerinden TNF-α düzeyleri incelendi. Postoperatif ilk ay içerisinde atriyal fibrilasyon ritmi gelişen hastalar ile diğer hastalar demografik ve operasyona ait verileri ve TNF-α düzeyleri açısından karşılaştırıldı. B Bu ul lg gu ul la ar r: : Yedi hastada (%14) postoperatif dönemde atriyal fibrilasyon gelişti. Atriyal fibrilasyon gözlenen hastaların diğer hastalardan daha ileri yaşta olduğu saptanırken (70,6±5,3'e karşı 58,6±9,5 yıl, p=0,001), diğer parametreler arasında istatistiksel olarak anlamlı bir fark saptanmadı. Hastaların operasyona ait verileri karşılaştırıldığında da, istatistiksel olarak anlamlı bir fark saptanmadı. TNF-α düzeyleri ekstrakorporal dolaşım boyunca hareketli bir seyir gösterdi. Atriyal fibrilasyon gelişen hastalar ile diğer hastaların TNF-α düzeyleri arasında, bazal dönemde [sırasıyla 8,15 (7,59-9,84) ve 8,30 (7,80-10,33) pg/ml, p=0,806], iskemi ve reperfüzyon dönemlerindeki değişimlerinde istatistiksel farklılık bulunamamıştır [İskemi dönemi yüzde değişimi: 0,10 (-0,03-0,45)'e karşı 0,01 (-0,07-0,37) pg/ml, p=0,106, reperfüzyon dönemi yüzde değişimi; 0,03 (-0,02-0,24)'e karşı 0,01 (-0,11-0,18) pg/ml, p=0,246]. Hastaların postoperatif verileri incelendiğinde TNF-α düzeyleri ile herhangi bir korelasyon gözlenmedi. S So on nu uç ç: : Kalp cerrahisi sonrasında görülen atriyal fibrilasyon için ileri yaş önemli bir risk faktörüdür. İntraoperatif olarak değerlendi-rilen yüksek TNF-α düzeyleri, özellikle riskli hasta gruplarında postoperatif atriyal fibrilasyon için bir prediktör olabilir.A An na ah ht ta ar r K Ke el li im me el le er r: : Tümör nekroz faktörü alfa (36-68); atriyal fibrilasyon; torasik cerrahi A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: It has been thought that systemic inflammatory response is one of the most important factors on the etiology of atrial fibrillation after cardiac surgery. In this study, we investigated the relationship between atrial fibrillation after cardiac surgery and TNF-α, which plays an important role in systemic inflammatory response. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Fifty patients who underwent revascularization surgery with more than three target vessels were enrolled to the study. TNF-α level was measured in the blood samples collected intraoperatively from coronary sinus at basal, ischemia and reperfusion periods. The patients with postoperative atrial fibrillation were compared with the other enrolled patients for demographic and surgical data and for TNF-α l...

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The Changes and Effects of the Plasma Levels of Tumor Necrosis Factor after Coronary Artery Bypass Surgery with Cardiopulmonary Bypass

Cited by 14 publications

References 43 publications

Effects of topical hypothermia on postoperative inflammatory markers in patients undergoing coronary artery bypass surgery : cardiovascular topic

Effects of topical hypothermia on postoperative inflammatory markers in patients undergoing coronary artery bypass surgery : cardiovascular topic

Telmisartan decreases microalbuminuria in patients with type 2 diabetes mellitus following coronary artery bypass grafting

Can TNF-α be a Predictor for Atrial Fibrillation After Cardiac Surgery?

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