The change in serum Thiol/Disulphide homeostasis after transrectal ultrasound guided prostate biopsy

Abstract

Objectives The aim of this prospective clinical study was to investigate variations in a novel oxidative stress marker (thiol/disulphide homeostasis) in men who underwent transrectal ultrasound guided prostate biopsy (TRUSB).Materials and Methods A total of 22 men undergoing TRUSB of the prostate were enrolled in the study. Patients with abnormal digital rectal examination and/or total prostate specific antigen (PSA) over 4ng/mL underwent TRUSB with 12 cores. Serum samples were obtained before and just after the procedure to evaluate the possible changes in thiol/disulphide homeostasis. Mean age, total PSA and free PSA, prostate volume and histopathological data were also recorded.Results Mean age of the study population was 65.05±8.89 years. Significant decreases in native and total thiol levels were documented after the biopsy procedure. However, serum disulphide levels and disulphide/native thiol, disulphide/total thiol and native/total thiol ratios did not significantly change after TRUSB. No correlation was observed between oxidative parameters and total PSA and free PSA levels, prostate volume and histopathology of the prostate. However, mean patient age was significantly correlated with mean native and total thiol levels.Conclusion Significant decreases in serum native and total thiol levels related to the prostate biopsy procedure suggest that TRUSB causes acute oxidative stress in the human body. Since our trial is the first in the current literature to investigate these oxidative stress markers in urology practice, additional studies are warranted.

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

“…Similarly, authors have demonstrated that NT and TT levels decreased in patients underwent transrectal ultrasound guided prostate biopsy [107].…”

Systemic oxidative stress and antioxidant capacity in cancer patients

“…In addition, lower thiol levels might have a prognostic value in the development of chemotherapyinduced cardiac toxicity [15]. It has previously been observed that total thiol levels, native thiol levels and disulfide levels are decreased after a prostate biopsy [26], but it is unknown whether this has any prognostic significance. These results might lead to the assumption that patients should be treated with antioxidants to improve their prognosis.…”

Role of native Thiol, total Thiol and dynamic Disulphide in diagnosis of patient with prostate cancer and prostatitis

“…Some studies investigated oxidative markers in semen and urine (15). However, there are very few studies regarding thiol / disulphide in the field of urology (16, 17). In this paper, an invasive procedure such as a biopsy has been shown to increase oxidative stress in the prostate tissue (17).…”