The Change in Low-Density Lipoprotein Cholesterol Concentration is Positively Related to Plasma Docosahexaenoic Acid but not Eicosapentaenoic Acid

Itakura, Hiroshige; Yokoyama, Mitsuhiro; Matsuzaki, Masunori; Saitō, Yasushi; Origasa, Hideki; Ishikawa, Yuichi; Oikawa, Shinichi; Sasaki, Jun; Kita, Toru; Kitabatake, Akira; Nakaya, Noriaki; Sakata, Toshiie; Shimada, Kazuyuki; Shirato, Kunio; Matsuzawa, Yūji

doi:10.5551/jat.11593

Cited by 15 publications

(5 citation statements)

References 24 publications

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“…Our results were in line with the results of Japanese previous studies which showed that higher level of omega-3 fatty acids was associated with increased LDL cholesterol (Nogi et al, 2007, Inoue et al, 2013, Itakura et al, 2012). A meta-analysis reported that omega-3 fatty acid supplements containing both EPA and DHA reduced TG but concomitantly increased LDL cholesterol (Eslick et al, 2009), and intake of omega-3 fatty acids from daily diet might influenced serum lipids metabolism in our subjects.…”

Section: Discussionsupporting

confidence: 93%

Omega-3 fatty acids related to cognitive impairment in patients with schizophrenia

Satogami

Takahashi

Yamada

et al. 2017

Schizophrenia Research: Cognition

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Cognitive impairment is strongly associated with functional outcome in patients with schizophrenia but its pathophysiology remains largely unclear. Involvement of omega-3 fatty acids in the cognitive function of healthy individuals and patients with neuropsychiatric disease has received increasing attention. The aim of this study was to examine the relationship between omega-3 fatty acids with cognitive function, social function, and psychiatric symptoms in patients with schizophrenia. The subjects included 30 patients with schizophrenia or schizoaffective disorder. Psychiatric symptoms, cognitive function, and social function were assessed using the Positive and Negative Syndrome Scale, the Brief Assessment of Cognition in Schizophrenia (BACS), and the Social Functioning Scale (SFS), respectively. Blood serum omega-3 fatty acids were assessed using gas chromatography. The BACS composite score was significantly correlated with blood eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) levels. In addition, a daily dose of antipsychotic medication was negatively and significantly correlated with the blood DHA level and with the BACS composite score. Step-wise multiple regression analyses demonstrated that the SFS score was significantly associated with the BACS composite score. Our results indicate that reduced blood omega-3 fatty acids are associated with cognitive impairment, which then impacts social functioning outcomes in schizophrenia.

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Section: Discussionsupporting

confidence: 93%

Omega-3 fatty acids related to cognitive impairment in patients with schizophrenia

Satogami

Takahashi

Yamada

et al. 2017

Schizophrenia Research: Cognition

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“…DHA preparations increases serum LDL-C and decreases serum TG [7,8]. A subanalysis of the JELIS trial reported that serum EPA levels did not affect the serum LDL-C levels, but that serum DHA levels increased serum LDL-C levels [31]. These findings strongly support our own results.…”

Section: Discussionsupporting

confidence: 69%

Association of atherosclerosis-related markers and its relationship to n-3 polyunsaturated fatty acids levels with a prevalence of coronary artery disease in an urban area in Japan

2013

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Higher intakes of fish and n-3 polyunsaturated fatty acids (n-3PUFAs: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) are associated with a reduced risk of coronary artery disease (CAD). We investigated the relationships between fish-derived n-3PUFAs and prevalence of CAD, and to assess the association of n-3PUFAs with atherosclerosis-related markers in an urban area. This study was designed as a hospital-based cross-sectional study on 649 consecutive outpatients who had undergone regular examinations between April 2009 and October 2009. After adjustments for the coronary risk factors in a multilogistic regression analysis of variables for which a significant difference was identified between the group of patients with a prevalence of CAD and the group with no prevalence of CAD, the multivariable odds ratio (95 % confidence interval) was 0.394 (0.205/0.760; P = 0.005) for the highest (92.4-373.5 μg/ml) versus lowest (6.2-40.0 μg/ml) quartile of serum EPA values and 0.433 (0.228/0.824; P = 0.011) for the highest (160.7-451.8 μg/ml) versus lowest (35.7-100.7 μg/ml) quartile of serum DHA values. Multivariate regression analyses after adjustment for risk factors showed that higher serum EPA and DHA levels were independent variables of a higher level of serum apolipoprotein A-1, a major compound of high-density lipoprotein. However, the results suggested that there might be conflicting effects of EPA and DHA in regard of the serum levels of other lipid markers. This cross-sectional study suggests that higher serum levels of n-3PUFAs were associated with a lower prevalence of CAD and an increase in serum apolipoprotein A-1 level, even in an urban area.

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“…On the other hand, DHA elevates the levels of HDL-C and LDL-C and increases HDL and LDL particle size [7,[27][28][29]. Moreover, Itakura et al reported that the changes in DHA, but not in EPA, were positively correlated with the changes in LDL-C [30], although DHA mildly reduced both the heart rate at rest and blood pressure [27]. Thus, EPA and DHA may have different effects with regard to the onset of ACS.…”

Section: Discussionmentioning

confidence: 99%

The ratio of eicosapentaenoic acid to arachidonic acid is a critical risk factor for acute coronary syndrome in middle-aged older patients as well as younger adult patients

Serikawa

Miura

Okabe

et al. 2014

Journal of Cardiology

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The Change in Low-Density Lipoprotein Cholesterol Concentration is Positively Related to Plasma Docosahexaenoic Acid but not Eicosapentaenoic Acid

Cited by 15 publications

References 24 publications

Omega-3 fatty acids related to cognitive impairment in patients with schizophrenia

Omega-3 fatty acids related to cognitive impairment in patients with schizophrenia

Association of atherosclerosis-related markers and its relationship to n-3 polyunsaturated fatty acids levels with a prevalence of coronary artery disease in an urban area in Japan

The ratio of eicosapentaenoic acid to arachidonic acid is a critical risk factor for acute coronary syndrome in middle-aged older patients as well as younger adult patients

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