The chameleon rash: a review of the polyphenotypic dermatoses of dermatomyositis

Connolly, A.; Gordon, Patrick; Hannah, Jennifer; Creamer, Daniel

doi:10.1111/ced.14689

Cited by 7 publications

(9 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gottron papule, heliotrope rash and V sign are the prominent characteristics of DM [13]. A single-center study involving 779 patients with IIM found that infection was more common in patients with dermatomyositis than in those with polymyositis, and they also found that a heliotrope rash is a risk factor for infection [14]. This nding supported symptom status as a key predictor of infection.…”

Section: Discussionmentioning

confidence: 85%

“…Several studies have indicated that ILD is an independent risk factor for infection. [14][15] Interestingly, we found a reduced risk of infection in patients who were positive for anti-Jo1 antibodies. This was consistent with the research of Yongpeng et al [14].…”

Section: Discussionmentioning

confidence: 96%

“…[14][15] Interestingly, we found a reduced risk of infection in patients who were positive for anti-Jo1 antibodies. This was consistent with the research of Yongpeng et al [14]. However, another study suggested otherwise [15].…”

Section: Discussionmentioning

confidence: 96%

See 2 more Smart Citations

Clinical features of idiopathic inflammatory myopathies with infection based on a cluster analysis

Cheng

et al. 2022

Preprint

View full text Add to dashboard Cite

Objectives. Patients with idiopathic inflammatory myopathies (IIM), referred to as myositis, are prone to infectious complications, which hinder the treatment of the disease and worsen the outcome of patients. The purpose of this study was to explore the different types of infectious complications in patients with myositis and to determine the predisposing factors for clinical reference. Methods. A retrospective study was conducted on 66 patients with IIMwho were divided into different types by an unsupervised analysis of their clinical manifestations, laboratory features, and autoantibody characteristics. Combined with the incidence of infectious complications, the types of infectious pathogens and the sites of infection, the characteristics of infection and susceptibility factors were explored. Results. Three clusters with significantly different clinical characteristics and coinfection rates were identified (76.2% vs. 41.6% vs. 36.4%, p=0.0139). Cluster 1 (n = 12) had a moderate risk of infection, with an infection rate of 41.6%. The patients in cluster 1 had a high probability of positive mechanic's hands, periungual erythema, anti-Ro52 antibody, and anti-Jo1 antibody. CD3 and CD4 were the highest among the three groups. Cluster 2 (n = 21) had a high risk of infection, and the incidence of infection was 76.2%. Almost all patients in this cluster had a rash, prominent clinical symptoms, and decreased WBC, PMN, LYM, CD3 and CD4counts. Cluster 3 (n=33) had a low risk of infection, with an infection rate of 36.4%. Compared with the other two clusters, cluster 3 (n=33) lacked a typical rash but had a high ANA positive rate. The patients in cluster 1 and cluster 3 were mainly infected by viruses, followed by bacterial infections. In the cluster 2 patients, bacterial infections were the most prevalent. Fungal and Pneumocystis carinii were common causes of cluster 2 and 3 infections. In addition, the patients within a cluster often have a single infection, and pulmonary infections are the most common. Conclusion. We clustered the patients with IIM complicated with infection into three different types by their clinical symptoms and found that there were differences in the infection risk and infection types among the different cluster groups. Please ensure that the intended meaning has been maintained in this edit.

show abstract

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Clinical features of idiopathic inflammatory myopathies with infection based on a cluster analysis

Cheng

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Dermatomyositis is an autoimmune connective tissue disease with heterogeneous cutaneous and muscular manifestations. 1 Cases of dermatomyositis emerging in association with SARS-CoV-2 vaccination are rare, with most cutaneous reactions to these vaccines now recognised as infrequent and transient. 2 Herein we report a case of a young, previously well female with rapid onset of classic dermatomyositis signs and symptoms after such vaccination.…”

Section: Introductionmentioning

confidence: 99%

“…Dermatomyositis is an autoimmune connective tissue disease with heterogeneous cutaneous and muscular manifestations 1 . Cases of dermatomyositis emerging in association with SARS‐CoV‐2 vaccination are rare, with most cutaneous reactions to these vaccines now recognised as infrequent and transient 2 .…”

Section: Introductionmentioning

confidence: 99%

Acute onset dermatomyositis with NXP‐2 antibodies after Sars‐CoV‐2 vaccination in a 20‐year‐old female

Porter

Byrne

Sarfaraz

et al. 2023

JEADV Clinical Practice

View full text Add to dashboard Cite

Dermatomyositis is an autoimmune connective tissue disease with variable cutaneous and systemic manifestations. While multiple cutaneous reactions to SARS-CoV-2 vaccination have been described, vaccine-associated emergence of dermatomyositis has rarely been reported. Cases of deterioration in preexisting connective tissue diseases have been described following both vaccination and COVID-19 infection. A potential mechanism of immune system activation and dysregulation has been suggested. This case describes acute onset of dermatomyositis in a young female, presenting with classic cutaneous features including Gottron papules, Holster sign and proximal nail fold erythema, accompanied with myalgia and fatigue. Laboratory findings of elevated creatine kinase and myositis-specific autoantibodies confirmed the diagnosis, with supportive histological findings of necrotic keratinocytes at the dermoepidermal junction. In keeping with the typical progression of dermatomyositis with NXP-2 autoantibodies, cutaneous findings resolved rapidly, while systemic manifestations slowly improved with treatment.Thorough investigations for underlying malignancy were completed. This case adds to the limited medical literature surrounding these cases and further highlights the importance of consideration of SARS-CoV-2 vaccination in the immunologic pathophysiology of autoimmune connective tissue diseases.

show abstract

Dermatomyositis

Gordon,

Creamer

2024

Rook's Textbook of Dermatology

View full text Add to dashboard Cite

Dermatomyositis (DM) is an autoimmune disorder affecting the skin, skeletal muscle and, in some patients, the lungs. At one end of the spectrum myopathy predominates, at the other end skin disease is prominent with minimal or absent myositis (amyopathic DM). Most patients develop a facial rash initially; all sites can be affected but upper eyelid involvement is typical. A rash on the hands, extensor surfaces of the limbs, upper torso and scalp tends to occur subsequently. Muscle disease in DM usually becomes clinically apparent in the weeks to months after the onset of skin signs. DM can be a paraneoplastic disorder with up to 30% of patients having an internal malignancy, therefore investigations must include screening for an underlying neoplasm. Myositis‐specific antibodies (MSAs) target a variety of cell function proteins, some of which may be pathogenic. Currently MSAs are used to stratify DM patients into subgroups characterised by shared clinical traits. Systemic corticosteroid is the primary treatment for DM when both skin and muscles are involved. Immunosuppressant drugs (such as mycophenolate mofetil, azathioprine and tacrolimus) are used to control the disease as the dose of prednisolone is tapered. Intravenous immunoglobulin can be used as a steroid‐sparing agent; it is effective for both muscle and skin features in DM. Topical therapy for skin DM, including super‐potent steroids, is often disappointing; however recent studies have suggested the efficacy of Janus kinase inhibitors for DM skin disease.

show abstract

The chameleon rash: a review of the polyphenotypic dermatoses of dermatomyositis

Cited by 7 publications

References 26 publications

Clinical features of idiopathic inflammatory myopathies with infection based on a cluster analysis

Clinical features of idiopathic inflammatory myopathies with infection based on a cluster analysis

Acute onset dermatomyositis with NXP‐2 antibodies after Sars‐CoV‐2 vaccination in a 20‐year‐old female

Dermatomyositis

Contact Info

Product

Resources

About