The challenges of foodborne pathogens and antimicrobial chemotherapy: A global perspective

Nyenje, Mirriam Ethel; Rol,; Ndip, N.

doi:10.5897/ajmrx12.014

Cited by 25 publications

(14 citation statements)

References 167 publications

(170 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the emerging problems related with foodborne bacteria is the increase of antibiotic resistance. It is known that changes in the patterns of food consumption (the preference for fresh and minimally processed foods), alterations in the globalization of the food market, and the emergence of multidrug resistant (MDR) bacteria have turned the control of foodborne diseases into a challenge [7,8]. According to the Centre for Disease Control and Prevention [9], about 400,000 people per year are affected by foodborne infections caused by MDR bacteria in the United States.…”

Section: Introductionmentioning

confidence: 99%

The Remarkable Effect of Potassium Iodide in Eosin and Rose Bengal Photodynamic Action against Salmonella Typhimurium and Staphylococcus aureus

et al. 2019

View full text Add to dashboard Cite

Antimicrobial photodynamic therapy (aPDT) has been shown as a promising technique to inactivate foodborne bacteria, without inducing the development of bacterial resistance. Knowing that addition of inorganic salts, such as potassium iodide (KI), can modulate the photodynamic action of the photosensitizer (PS), we report in this study the antimicrobial effect of eosin (EOS) and rose bengal (RB) combined with KI against Salmonella enterica serovar Typhimurium and Staphylococcus aureus. Additionally, the possible development of bacterial resistance after this combined aPDT protocol was evaluated. The combination of EOS or RB, at all tested concentrations, with KI at 100 mM, was able to efficiently inactivate S. Typhimurium and S. aureus. This combined approach allows a reduction in the PS concentration up to 1000 times, even against one of the most common foodborne pathogenics, S. Typhimurium, a gram-negative bacterium which is not so prone to inactivation with xanthene dyes when used alone. The photoinactivation of S. Typhimurium and S. aureus by both xanthenes with KI did not induce the development of resistance. The low price of the xanthene dyes, the non-toxic nature of KI, and the possibility of reducing the PS concentration show that this technology has potential to be easily transposed to the food industry.

show abstract

Section: Introductionmentioning

confidence: 99%

The Remarkable Effect of Potassium Iodide in Eosin and Rose Bengal Photodynamic Action against Salmonella Typhimurium and Staphylococcus aureus

et al. 2019

View full text Add to dashboard Cite

show abstract

“…It is important to note that many of the isolates obtained from outbreaks are not tested for antimicrobial susceptibility; due to the various problems that these strains can create, the antimicrobial susceptibility test should be performed. They have been reported to be causative agents of outbreaks in blood infections and wounds in immunocompromised patients in hospitals [65,73].…”

Section: S Aureus Produces Various Toxins Staphylococcal Enterotoximentioning

confidence: 99%

“…It is estimated that 0.1 μg of enterotoxin can cause staphylococcal poisoning in humans. Apart from causing poisoning, S. aureus can also cause toxic shock syndrome due to the production of the Toxic Shock Syndrome Toxin 1 (TSST-1) and Enterotoxin Type B [65,73,74].…”

Section: S Aureus Produces Various Toxins Staphylococcal Enterotoximentioning

confidence: 99%

“…The mainly involved food products in outbreaks and where S. aureus can grow optimally, since they are stored at room temperature, are meat and its derived products, poultry and eggs, milk and its derived products, salads, and bakery products (cream-filled cakes and stuffed sandwiches) [65,73].…”

Section: S Aureus Produces Various Toxins Staphylococcal Enterotoximentioning

confidence: 99%

“…Furthermore, a toxic infection (toxicoinfection), formerly known as a toxin-mediated infection, is caused by eating food with bacteria that grow and produce a toxin inside the body [18,[64][65][66].…”

Section: Foodborne Diseasesmentioning

confidence: 99%

See 2 more Smart Citations

Food Poisoning Caused by Bacteria (Food Toxins)

Hernández-Cortez¹,

Palma-Martínez²,

UrielGonzalez-Avila³

et al. 2017

Poisoning - From Specific Toxic Agents to Novel Rapid and Simplified Techniques for Analysis

View full text Add to dashboard Cite

In the environment, there are polluting substances that can cause adverse reactions in human beings when entering the body through different ways (ingestion, inhalation, injection, or absorption). The main pollutants can be poisons, chemical compounds, toxic gases, and bacterial toxins. These can be found in different places and their effects depend on the dose and exposure time. Furthermore, foodborne diseases (FBDs) can cause disability; these diseases can be caused by toxins produced by bacteria or other toxic substances in the food, which can cause severe diarrhea, toxic shock syndrome, debilitating infections such as meningitis and even death. FBDs are transmitted through food contaminated with pathogenic microorganisms that have multiple factors of virulence, which gives them the ability to cause an infection; some bacterial genres can produce toxins directly in the food, but other genres can produce them once they have colonized the intestine. Among the pathogens involved in FBDs that are also considered to be toxigenic are Salmonella spp., Vibrio parahaemolyticus, Vibrio cholerae, Staphylococcus aureus, Clostridium botulinum, Clostridium perfringens, Bacillus cereus, Listeria monocytogenes. Foodborne diseases can be prevented and acute diarrhea syndromes, fever and even death from dehydration can be avoided, especially in children under the age of 5 and in immunocompromised people.

show abstract

Comparative assessment of the therapeutic drug targets of C. botulinum ATCC 3502 and C. difficile str. 630 using in silico subtractive proteomics approach

Bhardwaj

Haque

Somvanshi

2019

J of Cellular Biochemistry

View full text Add to dashboard Cite

Growing antimicrobial resistance of the pathogens against multiple drugs posed a serious threat to the human health worldwide. This fueled the need of identifying the novel therapeutic targets that can be used for developing new class of the drugs. Recently, there is a substantial rise in the rate of Clostridium infections as well as in the emergence of virulent and antibiotic resistant strains. Hence, there is an urgent need for the identification of potential therapeutic targets and the development of new drugs for the treatment and prevention of Clostridium infections. In the present study, a combinatorial approach involving systems biology and comparative genomics strategy was tested against Clostridium botulinum ATCC 3502 and Clostridium difficile str. 630 pathogens, to render potential therapeutic target at qualitative and quantitative level. This resulted in the identification of five common (present in both the pathogens, 34 in C. botulinum ATCC 3502 and 42 in C. difficile str. 630) drug targets followed by virtual screening–based identification of potential inhibitors employing molecular docking and molecular dynamics simulations. The identified targets will provide a solid platform for the designing of novel wide‐spectrum lead compounds capable of inhibiting their catalytic activities against multidrug‐resistant Clostridium in the near future.

show abstract

The challenges of foodborne pathogens and antimicrobial chemotherapy: A global perspective

Cited by 25 publications

References 167 publications

The Remarkable Effect of Potassium Iodide in Eosin and Rose Bengal Photodynamic Action against Salmonella Typhimurium and Staphylococcus aureus

The Remarkable Effect of Potassium Iodide in Eosin and Rose Bengal Photodynamic Action against Salmonella Typhimurium and Staphylococcus aureus

Food Poisoning Caused by Bacteria (Food Toxins)

Comparative assessment of the therapeutic drug targets of C. botulinum ATCC 3502 and C. difficile str. 630 using in silico subtractive proteomics approach

Contact Info

Product

Resources

About