The challenge of testing chemicals for potential carcinogenicity using multiple short-term assays: An analysis of a proposed test battery for hair dyes

Rosenkranz, Herbert S.; Cunningham, Suzanne L.; Mermelstein, Robert; Cunningham, Albert R.

doi:10.1016/j.mrgentox.2007.05.008

Cited by 18 publications

(5 citation statements)

References 39 publications

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“…They are also aesthetically objectionable for drinking and other purposes. Dyes can also cause allergy, dermatitis, skin irritation and also provoke cancer and mutation in humans (Brookstein, 2009;de Lima et al, 2007;Rosenkranz et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Application of cupuassu shell as biosorbent for the removal of textile dyes from aqueous solution

Cardoso

Lima

Pinto

et al. 2011

Journal of Environmental Management

226

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The cupuassu shell (Theobroma grandiflorum) which is a food residue was used in its natural form as biosorbent for the removal of C.I. Reactive Red 194 and C.I. Direct Blue 53 dyes from aqueous solutions. This biosorbent was characterized by infrared spectroscopy, scanning electron microscopy, and nitrogen adsorption/desorption curves. The effects of pH, biosorbent dosage and shaking time on biosorption capacities were studied. In acidic pH region (pH 2.0) the biosorption of the dyes were favorable. The contact time required to obtain the equilibrium was 8 and 18 h at 298 K, for Reactive Red 194 and Direct Blue 53, respectively. The Avrami fractionary-order kinetic model provided the best fit to experimental data compared with pseudo-first-order, pseudo-second-order and chemisorption kinetic adsorption models. The equilibrium data were fitted to Langmuir, Freundlich, Sips and Radke-Prausnitz isotherm models. For both dyes the equilibrium data were best fitted to the Sips isotherm model.

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Section: Introductionmentioning

confidence: 99%

Application of cupuassu shell as biosorbent for the removal of textile dyes from aqueous solution

Cardoso

Lima

Pinto

et al. 2011

Journal of Environmental Management

226

View full text Add to dashboard Cite

show abstract

“…4 In addition, many dyes and their by-products are harmful to human and animal life. 5,6 In view of the toxic properties of dyes, immediate attention is required to develop suitable methods for the removal of dyes from wastewater. Various processes are available in the literature to remove dyes from wastewater [7][8][9][10][11][12][13][14] but due to different limitations, the processes are not very efficient.…”

Section: Introductionmentioning

confidence: 99%

Removal of safranin-O dye from aqueous solution using modified red mud: kinetics and equilibrium studies

Sahu

Patel

2015

RSC Adv.

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“…Second, a Bayesian hybrid model was developed that combined predictions from the fragment and ligand model ( i.e. , consistent as well divergent predictions) with a final determination as to activity class based on Bayes' theorem [30-32]. …”

Section: Resultsmentioning

confidence: 99%

Mammary carcinogen-protein binding potentials: novel and biologically relevant structure–activity relationship model descriptors

Cunningham

Qamar

Carrasquer

et al. 2010

SAR and QSAR in Environmental Research

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Previously, SAR models for carcinogenesis used descriptors that are essentially chemical descriptors. Herein we report the development of models with the cat-SAR expert system using biological descriptors (i.e., ligand-receptor interactions) rat mammary carcinogens. These new descriptors are derived from the virtual screening for ligand-receptor interactions of carcinogens, non-carcinogens, and mammary carcinogens to a set of 5494 target proteins. Leave-one-out validations of the ligand mammary carcinogen non-carcinogen model had a concordance between experimental and predicted results of 71% and the mammary carcinogen non-mammary carcinogen model was 72% concordant. The development of a hybrid fragment-ligand model improved the concordances to 85 and 83%, respectively. In a separate external validation exercise, hybrid fragment-ligand models had concordances of 81 and 76%. Analyses of example rat mammary carcinogens including the food mutagen and estrogenic compound PhIP, the herbicide atrazine, and the drug indomethacin, the ligand model identified a number of proteins associated with each compound that had previously been referenced in Medline in conjunction with the test chemical and separately with association to breast cancer. This new modelling approach can enhance model predictivity and help bridge the gap between chemical structure and carcinogenic activity by descriptors that are related to biological targets.

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The challenge of testing chemicals for potential carcinogenicity using multiple short-term assays: An analysis of a proposed test battery for hair dyes

Cited by 18 publications

References 39 publications

Application of cupuassu shell as biosorbent for the removal of textile dyes from aqueous solution

Application of cupuassu shell as biosorbent for the removal of textile dyes from aqueous solution

Removal of safranin-O dye from aqueous solution using modified red mud: kinetics and equilibrium studies

Mammary carcinogen-protein binding potentials: novel and biologically relevant structure–activity relationship model descriptors

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