The challenge of pulmonary Pseudomonas aeruginosa infection: How to bridge research and clinical pathology

Mendes, Odete

doi:10.1016/b978-0-323-85730-7.00019-9

Cited by 6 publications

(4 citation statements)

References 147 publications

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“…https://doi.org/10.56294/saludcyt2023404 5 Kumar N, et al Doripenem "Doripenem is a brand-new 1-methyl-carbapenem" which is stable against -lactamases with resistance to inactivation by renal dihydro peptidases. All Gram-negative bacteria and Gram-positive bacteria, with P. aeruginosa, are susceptible to doripenem in vitro, except MRSA and a few Enterococcus species.…”

Section: Alternatives To Antimicrobials Colistinmentioning

confidence: 99%

“…Understanding the pathoadaptability of this pathogen requires an understanding of the massive P. aeruginosa genome, which contains a variety of genetic regulatory mechanisms, particularly including novel genomic tools that allow the evaluation of differences and similarities among P. aeruginosa populations. (5) Schematic representations of the initial infections caused by P. aeruginosa are exposed in figure 1.…”

Section: Introductionmentioning

confidence: 99%

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Pseudomonas aeruginosa: A Persistent Pathogen and Current Approaches to Treatment- Microbiology

Kumar

VASUNDHARA

Chavan

2023

Salud, Ciencia y Tecnología

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Pseudomonas aeruginosa (P. aeruginosa) representa un importante patógeno bacteriano, principalmente porque puede infectar a huéspedes inmunodeprimidos, pacientes hospitalizados y personas con fibrosis quística (FQ). La resistencia a los antimicrobianos ha aumentado debido a la vigilancia de las infecciones nosocomiales por P. aeruginosa, con tendencia a la resistencia a los fármacos modelo y a los carbapenemes. Algunos de los mecanismos de resistencia a los antimicrobianos incluyen la regulación a la baja de las porinas de la membrana externa, las -lactamasas y las bombas de eflujo de múltiples fármacos. Las toxinas que se secretan y pueden formar BioFlim (BF) son ejemplos de mecanismos de virulencia. La terapia eficaz de la infección causada por P. aeruginosa requiere la administración precoz de los antibióticos adecuados, medidas de control de la fuente y, cuando sea posible, prevención. Se supone que la desescalada antibacteriana debe considerarse en los pacientes por una respuesta clínica positiva, en particular cuando se identificaron susceptibilidades antibacterianas. Es posible que se necesiten antibacterianos menos comunes, incluida la Colistina, para tratar la P. aeruginosa multirresistente, aunque pronto se debería poder acceder a otros antibacterianos antipseudomónicos.

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Section: Alternatives To Antimicrobials Colistinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pseudomonas aeruginosa: A Persistent Pathogen and Current Approaches to Treatment- Microbiology

Kumar

VASUNDHARA

Chavan

2023

Salud, Ciencia y Tecnología

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“…Pseudomonas aeruginosa is an opportunistic human pathogen that is commonly isolated from other natural environments such as soil or freshwater bodies of water. It is a leading cause for nosocomial infections in the U.S. and can infect nearly every organ system in the mammalian body including the skeletal system, cardiovascular system, digestive system, integumentary system, reproductive system, and respiratory system [1][2][3][4][5][6]. Its ability to survive in such a wide range of habitats is largely due to its large, plastic genome leading to wide metabolic capabilities [7,8].…”

Section: Introductionmentioning

confidence: 99%

Examining the influence of environmental factors on Acanthamoeba castellanii and Pseudomonas aeruginosa in co-culture

Cecil,

Yoder-Himes

2024

PLoS ONE

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Exploration of interspecies interactions between microorganisms can have taxonomic, ecological, evolutionary, or medical applications. To better explore interactions between microorganisms it is important to establish the ideal conditions that ensure survival of all species involved. In this study, we sought to identify the ideal biotic and abiotic factors that would result in high co-culture viability of two interkingdom species, Pseudomonas aeruginosa and Acanthamoeba castellanii, two soil dwelling microbes. There have been limited studies showing long-term interactions between these two organisms as co-culture can result in high mortality for one or both organisms suggesting a predator-predator interaction may exist between them. In this study, we identified biotic and abiotic conditions that resulted in a high viability for both organisms in long-term co-culture, including optimizing temperature, nutrient concentration, choice of bacterial strains, and the initial ratio of interacting partners. These two species represent ideal partners for studying microbial interactions because amoebae act similarly to mammalian immune cells in many respects, and this can allow researchers to study host-pathogen interactions in vitro. Therefore, long-term interaction studies between these microbes might reveal the evolutionary steps that occur in bacteria when subjected to intense predation, like what occurs when pathogens enter the human body. The culture conditions characterized here resulted in high viability for both organisms for at least 14-days in co-culture suggesting that long-term experimental studies between these species can be achieved using these culture conditions.

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“…P. aeruginosa is a member of the ESKAPE group of bacterial pathogens [7]. It is a dangerous opportunistic pathogen due to its intrinsic multidrug resistance, genomic plasticity, ability to survive and form biofilms on abiotic surfaces such as hospital equipment, and ability to evade the immune systems of humans, plants, and non-human animals [8][9][10][11][12]. P. aeruginosa commonly presents with three colony morphotypes: wild-type, small colony, and mucoid.…”

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confidence: 99%

Long-term Culturing ofPseudomonas aeruginosain Static, Minimal Nutrient Medium Results in Increased Pyocyanin Production, Reduced Biofilm Production, and Loss of Motility

Cecil,

Ornelas,

Phan

et al. 2024

Preprint

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Pseudomonas aeruginosais a multidrug-resistant opportunistic human pathogen that can survive in many natural and anthropogenic environments. It is a leading cause of morbidity in individuals with cystic fibrosis and is one of the most prevalent pathogens associated with nosocomial infections in the United States. It has been shown that this organism can survive and persist in low nutrient environments such as sink drains and inside the respiratory system of human hosts. How adaptation to these types of environments influences phenotypic traits of this organism has not been well studied. Here we implemented an experimental evolution system designed to imitate these environmental niches and identified phenotypic changes that occurred as a result of adaptation to such environments in six strains ofP. aeruginosawith varying life history and colony phenotypes. We observed that adaptation to low nutrient environments resulted in decreased generation time, reduced cell size, reduced biofilm formation, increased pyocyanin production, and decreased motility. Our work is significant as it allows us to predict how this organism will evolve in hospital and domestic environments and can help us improve treatment options for patients.

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The challenge of pulmonary Pseudomonas aeruginosa infection: How to bridge research and clinical pathology

Cited by 6 publications

References 147 publications

Pseudomonas aeruginosa: A Persistent Pathogen and Current Approaches to Treatment- Microbiology

Pseudomonas aeruginosa: A Persistent Pathogen and Current Approaches to Treatment- Microbiology

Examining the influence of environmental factors on Acanthamoeba castellanii and Pseudomonas aeruginosa in co-culture

Long-term Culturing ofPseudomonas aeruginosain Static, Minimal Nutrient Medium Results in Increased Pyocyanin Production, Reduced Biofilm Production, and Loss of Motility

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