The challenge of dry eye diagnosis

Savini, Giacomo; Prabhawasat, Pinita; Kojima, Takashi; Grueterich, Martin; Espana, Edgar M.; Goto, Eiki

doi:10.2147/opth.s1496

Cited by 233 publications

(229 citation statements)

References 177 publications

(249 reference statements)

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“…Even though STT has been used for over one hundred years as a common clinical test to diagnose dry eye, physical underpinnings are poorly understood [19][20][21][22][23][24][25][26]. To provide clinicians with insight into what is actually measured [18][19][20][21][22][23][24][25][26][27][28][29][30], it is essential to understand the physical foundations of STT.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Human tear-production rate from closed-eye Schirmer-strip capillary dynamics

Telles

Dursch

et al. 2017

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Section: Introductionmentioning

confidence: 99%

“…To provide clinicians with insight into what is actually measured [18][19][20][21][22][23][24][25][26][27][28][29][30], it is essential to understand the physical foundations of STT. Elucidation of the wetting kinetics in a Schirmer strip is particularly important when attempting to obtain quantitative lacrimal-production rates.…”

Section: Introductionmentioning

confidence: 99%

Human tear-production rate from closed-eye Schirmer-strip capillary dynamics

Telles

Dursch

et al. 2017

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…Some of the dry eye markers used in this study also lacked agreement with patient symptoms. Recently, more has been written about this perplexing feature in the diagnosis and treatment of dry eye [1,[31][32][33][34]. Better terminology is needed to reflect the ways in which the lacrimal/meibomian/corneal lacrimal functional unit can become compromised [34].…”

Section: Discussionmentioning

confidence: 99%

“…Its proper diagnosis and management can be challenging [1]. Developing practical and effective therapeutic strategies is often elusive and frequently must be customized to the individual patient.…”

Section: Introductionmentioning

confidence: 99%

The ONIT Study–Ocular Nutrition Impact on Tear Film

Mulqueeny¹

2015

AOVS

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Purpose: To better understand the role of a proprietary dietary supplement formulated to contain Omega 3 and seven other anti-inflammatories plays in patients with established clinical findings consistent with dry eye disease. Secondarily, this evaluation will attempt to discover if any of the diagnostic markers are predictive to the therapeutic approach of omega 3 anti-inflammatory dietary supplements. Design:Clinical-based, multi-center cohort study. Methods:This eight-week feasibility study was to determine if subjects presenting with dry eye confirmed by diagnostic markers and symptoms responded to nutritional therapy via an oral nutritional supplement (EyePromise EZ Tears™). Analyses were completed on a subgroup of subjects with 4 of 7 possible diagnostic criteria.Results: A total of 67 patients were enrolled between 18-79 years of age inclusive. At the conclusion of the study, improvement from baseline was demonstrated in OSDI decreasing scores by 38%. Improved tear breakup time and phenol red thread scores were seen and was reduced conjunctival staining. There was also a decrease noted in lid inflammation. Osmolarity scores were variable and inconclusive. Conclusion:Supplementation with this Omega-3 anti-inflammatory product in dry eye showed significant improvement in OSDI, TBUT, conjunctival staining lid inflammation and phenol red tear meniscus and corneal staining scores. This decrease in patient symptoms could be an indication of decreasing ocular surface inflammation and possible stabilization of the lipid layer. The change from baseline for these signs appears to be rapid, as differences were shown as early as one-week post-supplementation.

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“…Fluorescein LTMH measurement and Schirmer's test are invasive methods which, due to contact and usage of topical anaesthetics, can alter the measurements [1]. Thus AS-OCT provides a non-invasive, anaesthetic-free and speedy modality for in-situ evaluation of LTMH [ Figures 1A and 1B].…”

Section: Clinical Imagementioning

confidence: 99%

Documentation of Lower Tear Meniscus Using Anterior Segment Optical Coherence Tomography

Onkar¹

2017

J Eye Cataract Surg

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A twenty-four year old male presented with complaints of intermittent redness and burning sensation in both eyes, especially after continuous computer usage. His work entailed ten hours of computer usage on daily basis. His Snellen's visual acuity was 6/6 in both eyes. Schirmer's and tear break-up time readings were 18 mm, 8 sec and 16 mm, 8 sec in right and left eye respectively.Anterior segment optical coherence tomography (AS-OCT) was used to measure lower tear meniscus height (LTMH) which came out to be 404 millimeters in right eye and 398 mm in left eye. Fluorescein LTMH measurement and Schirmer's test are invasive methods which, due to contact and usage of topical anaesthetics, can alter the measurements [1]. Thus AS-OCT provides a non-invasive, anaesthetic-free and speedy modality for in-situ evaluation of LTMH [Figures 1A and 1B]. Clinical Image iMedPub Journals

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The challenge of dry eye diagnosis

Cited by 233 publications

References 177 publications

Human tear-production rate from closed-eye Schirmer-strip capillary dynamics

Human tear-production rate from closed-eye Schirmer-strip capillary dynamics

The ONIT Study–Ocular Nutrition Impact on Tear Film

Documentation of Lower Tear Meniscus Using Anterior Segment Optical Coherence Tomography

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