The challenge of diagnosing seborrheic keratosis by reflectance confocal microscopy

Guo, Aiyuan; Chen, J.; Yang, Caifeng; Ding, Yichen; Zeng, Qinghai; Tan, Lirong

doi:10.1111/srt.12582

Cited by 12 publications

(11 citation statements)

References 16 publications

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“…Reflectance confocal microscopy (RCM) has been applied for non-invasive evaluation of skin tumors. In one study, 390 patients with a clinically suspicious diagnosis of SK were included for RCM 11 . Dermatologists using this method could diagnose SK in 66.2% of patients but not in 24.9% of patients.…”

Section: Non-invasive Diagnosis Beyond the Naked Eyementioning

confidence: 99%

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Recent advances in managing and understanding seborrheic keratosis

Wollina

2019

F1000Res

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Seborrheic keratosis (SK) is a common benign epidermal tumor with predominance in adult patients. Whereas common SKs are more frequent in Caucasians, dermatosis papulosa nigra is more prevalent in patients with a Fitzpatrick skin type of at least 3. There seems to be a link between extrinsic skin aging and the occurrence of SK. Mutations of fibroblast growth factor receptor 3 and other signaling molecules are a frequent finding in SK lesions. However, this does not translate into any malignant potential. Viral infections are particularly common in genital lesions, although their pathogenetic relevance for SK is questionable. Different histologic and clinical subtypes have been identified. The great variability of SKs raises some difficulties in diagnosis. Dermoscopy is the preferred non-invasive diagnostic method, in particular to differentiate pigmented SKs from other pigment tumors, including cutaneous melanoma. Eruptive SKs can be a paraneoplastic condition known as the Leser–Trélat sign. New targeted cancer treatments can cause a pseudo-Leser–Trélat sign. The treatment in practice is mainly minor surgery, including cryosurgery, shave excisions, and laser-assisted removal. The medical approaches have only limited effects. Recently, two formulations for topical therapy have been evaluated: a product with 40% hydrogen peroxide (HP40) and an aqueous nitric–zinc complex. Based on clinical trials, HP40 seems to be a promising alternative to surgery, in particular for facial lesions.

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Section: Non-invasive Diagnosis Beyond the Naked Eyementioning

confidence: 99%

“…Dermatologists using this method could diagnose SK in 66.2% of patients but not in 24.9% of patients. The authors concluded that the great clinical variability of SKs and the restricted depth reached by RCM limit the use of this method for SK diagnosis 11 .…”

Section: Non-invasive Diagnosis Beyond the Naked Eyementioning

confidence: 99%

Recent advances in managing and understanding seborrheic keratosis

Wollina

2019

F1000Res

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“…It is in good agreement with histopathology. It has been used to evaluate a variety of skin diseases, including BCC, 7 SK, 8 melanoma, 9 psoriasis, 10 and acne 11 . Gerger et al 12 and Langley et al 13 evaluated the diagnostic ability of RCM in melanoma tumors, verified the applicability of RCM in differential diagnosis of benign nevus and melanoma, and demonstrated that RCM was more sensitive than dermoscope.…”

Section: Discussionmentioning

confidence: 99%

Application and challenge of reflectance confocal microscopy in the diagnosis of pigmented nevus

Tang

Huang

et al. 2020

Skin Research and Technology

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Pigmented nevus is a benign tumor composed of nests of melanocytes. From infants to the elderly, almost everyone has it. It can grow in any part of normal people. Based on different locations of melanocytes in the skin, pigmented nevus can be classified into junctional nevus, compound nevus, and intradermal nevus. Some grow on the head and face or the limbs which affect the appearance, while some grow in such friction-prone parts as the palm, sole, neck or back. If the pigmented nevus increases significantly in a short period of time, or leads to itching, burning, inflammation, bleeding, ulceration, etc, it indicates the nevus has a certain tendency for deterioration or may have turned canceration. Clinically, it should be distinguished from many other diseases such as seborrheic keratosis (SK), warts, basal cell carcinoma (BCC), and malignant melanoma (MM), 1 and its diagnosis is usually based on histological examination of skin biopsy. Reflectance confocal microscopy (RCM) is a new non-invasive method based on optical confocal principle with advantages of in situ, in vivo, non-invasive, dynamic, etc. 2 Some studies have described the characteristics of RCM images of pigmented nevus. It usually shows a clear and symmetrical border of the lesion, regular arrangement of the

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“…Seborrheic keratosis has a number of varying clinical and histopathologic features and can be challenging to diagnose with RCM 5 . Although streaming of epidermal keratinocytes has been a recognized feature of BCCs, it is important to keep in mind that this process can be seen in several other lesions including seborrheic keratoses.…”

Section: Discussionmentioning

confidence: 99%

Epidermal streaming seen in a seborrheic keratosis using reflectance confocal microscopy and histopathology correlation

2019

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The challenge of diagnosing seborrheic keratosis by reflectance confocal microscopy

Abstract: It is challenge to diagnose seborrheic keratosis by reflectance confocal microscopy. It may due to the variable clinical and RCM appearances of SK, and limited depth of RCM.

Cited by 12 publications

References 16 publications

Recent advances in managing and understanding seborrheic keratosis

Recent advances in managing and understanding seborrheic keratosis

Application and challenge of reflectance confocal microscopy in the diagnosis of pigmented nevus

Epidermal streaming seen in a seborrheic keratosis using reflectance confocal microscopy and histopathology correlation

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