The Challenge of Developing a Single-Dose Treatment for Scabies

Bernigaud, C.; Samarawickrama, Gangi; Jones, Malcolm K.; Gasser, Robin B.; Fischer, Katja

doi:10.1016/j.pt.2019.08.002

Cited by 32 publications

(21 citation statements)

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“…Novel controls for arthropod borne diseases are of increasing importance, as the WHO has suggested that 125 different arthropod species are resistant to at least one insecticide [50,51]. Recent evidence has suggested there is increased incidence of resistance in scabies mites to the two most commonly used drugs, Ivermectin and Permethrin, making the development of novel therapeutic interventions necessary for the control and eradication of scabies [50][51][52][53]. It is evident that research into the scabies microbiome is critical for disease control, and the significant advancements that have been made in this field thanks to the use of metagenomics technologies will result in novel areas for applied research and ultimately better patient outcomes.…”

Section: Future Directions For Researchmentioning

confidence: 99%

Understanding the role of the Scabies mite microbiota in the development of novel control strategies

2021

Journal of Cellular Immunology

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Section: Future Directions For Researchmentioning

confidence: 99%

Understanding the role of the Scabies mite microbiota in the development of novel control strategies

2021

Journal of Cellular Immunology

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“…These include poor adherence to treatments, high costs for resource-poor communities, single-drug modality and increasing treatment failure. [17][18][19] The possibility of reinfestation remains high when close contacts are not treated, or the disease is endemic in a population. Also, no currently available treatments possess the combined ability to kill eggs, or have a combined antibacterial and anti-inflammatory/ anti-itch properties.…”

Section: What This Study Hopes To Add?mentioning

confidence: 99%

Mass drug administration campaigns for scabies and impetigo: protocol for a systematic review and meta-analysis

Ghosh

Tesfaye

Manandhar

et al. 2021

bmjpo

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IntroductionScabies is recognised as a neglected tropical disease, disproportionately affecting the most vulnerable populations around the world. Impetigo often occurs secondarily to scabies. Several studies have explored mass drug administration (MDA) programmes, with some showing positive outcomes—but a systematic evaluation of such studies is yet to be reported. The main aim of this systematic review is to generate comprehensive evidence on the effect and feasibility of MDA programmes in reducing the burden of scabies and impetigo.Methods and analysisA systematic review and meta-analysis will be conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement. Electronic databases to be searched will include CINAHL EBSCOhost, Medline Ovid, ProQuest, Science Direct, PubMed and SCOPUS. In addition, grey literature will be explored via the Australian Institute of Health and Welfare, Australian Indigenous HealthInfoNet, Informit, OaIster database and WHO. No language restrictions will be applied. All treatment studies following an MDA protocol, including randomised/quasi-controlled trials, and prospective before–after interventional studies, will be considered. The main outcome is the change in prevalence of scabies and impetigo The Cochrane collaboration risk of bias assessment tool will be used for assessing the methodological quality of studies. A random-effect restricted maximum likelihood meta-analysis will be performed to generate pooled effect (OR) using STATA V.16. Appropriate statistical tests will be carried out to quantify heterogeneity between studies and publication bias.Ethics and disseminationEthical approval is not required since data will be extracted from published works. The findings will be communicated to the scientific community through a peer-reviewed journal publication. This systematic review will present an evidence on the effect of MDA interventions on scabies and impetigo, which is instrumental to obtain a clear understanding of the treatments widely used in these programmes.PROSPERO registration numberCRD42020169544,

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“…In addition, resistance to the mostly used miticides has emerged [6]. Novel drug with new modes of action could slow down the emergence of resistance if used alternated with existing drugs [7]. Studies have shown that essential oils such as clove, tea tree and palmorosa are effective against the motile stages of Sarcoptes mites [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Lemongrass (Cymbopogon citratus) oil: A promising miticidal and ovicidal agent against Sarcoptes scabiei

Liu

Bernigaud

et al. 2020

PLoS Negl Trop Dis

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BackgroundEssential oils may represent an alternative strategy for controlling scabies, a neglected tropical disease caused by the infestation of mite from the species Sarcoptes scabiei. Lemongrass (Cymbopogen citratus) oil is reported to possess pharmacological properties including antiparasitc, antioxidant, antimicrobial and anti-inflammatory. The aim of the present study was to assess the potential efficacy of lemongrass oil against the mites and eggs of Sarcoptes scabiei.

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The Challenge of Developing a Single-Dose Treatment for Scabies

Cited by 32 publications

References 80 publications

Understanding the role of the Scabies mite microbiota in the development of novel control strategies

Understanding the role of the Scabies mite microbiota in the development of novel control strategies

Mass drug administration campaigns for scabies and impetigo: protocol for a systematic review and meta-analysis

Lemongrass (Cymbopogon citratus) oil: A promising miticidal and ovicidal agent against Sarcoptes scabiei

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